Diurefar 40 Pharmedic treat hypertension, edema due to heart failure, cirrhosis, kidney disease (10 blisters x 12 tablets)

Dosage form Box of 10 blisters x 12 tablets
Specifications Furosemid
Ingredient High blood pressure, edema

Ingredient

Composition information	Content
Furosemid	40mg

Uses

Indications

Diurefar 40 is indicated in the following cases:

edema due to heart failure, cirrhosis, kidney disease (including nephrotic syndrome);

Hypertension (single therapy or in combination with other hypertension treatment).

Pharmacy

Furosemid is a sulfonamide diuretic that is a fast, strong, dosage -dependent effect group.

The drug works on the branch on the Henle straps, so it is classified as a diuretic group. The main mechanism of action of Furosemid is to inhibit the Na+ - K+ - 2Cl shipping system - in the thick section of the branch on the Henle straps, increasing the excretion of these electrolytes, accompanied by increased water export exercises.

The drug also reduces the reabsorption of Na+, Cl- and increases the excretion of K+ in the distance and can work directly on the nearby tube. Furosemid does not inhibit the anhydrase carbon dioxide and is not antagonistic with aldosterone. Forosemid increases the elimination of Ca2+, Mg2+, hydrogen, ammonium, bicarbonate and may also be phosphate through the kidney.

Losing a lot of kail, hydrogen and chlorine can cause alkaline metabolism. Due to reducing plasma volume, it can cause hypotension but usually only mitigate.

pharmacokinetics

Furosemid quickly absorbed through the digestive tract, bioavailable about 60 - 70%, but the drug absorbed erratically, affected by the form of medicine, disease processes and the presence of food.

In patients with heart failure, Furosemid absorption is even more erratic. Born can be reduced to 10% in kidney disease, increasing slightly in liver disease. When taken, the effect appears quickly after ½ hours, reaches the maximum effect after 1-2 hours and maintains the effect of 6-8 hours.

up to 99% of the blood Furosemide attached to plasma albumin. Furosemid is excreted mainly through urine, mostly in the form of non -metabolic. Half life eliminates 30 - 210 minutes in normal people, prolonged in infants and patients with liver and kidney failure.

Furosemid passes through the placenta and distributed into breast milk. The clearance of Furosemide does not increase when hemolysis.

Before taking Diurefar 40 Pharmedic treat hypertension, edema due to heart failure, cirrhosis, kidney disease (10 blisters x 12 tablets)

How to use

Take the tablet with a glass of water.

Dosage

Supporting treatment

Adults:

Normal dose ½ - 2 capsules, 1 time in the morning.

If not responded, giving the dose increased by 20 - 40mg at a time, 6-8 hours apart, until the desired effect (including weight loss).

After that, the effective dose can be given 1-2 times daily or for 2-4 days a week.

To maintain, the dose can be reduced in some patients. In severe cases, you can carefully adjust the dose up to 600mg/day.

Treatment of hypertension

Adults:

The usual dose is 20 - 40mg/time, 2 times a day.

Strictly monitor blood pressure when using Furosemid alone or in combination with other anti -hypertension drugs, especially when starting treatment.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Treatment: Supporting treatment and includes compensation for the amount of water and electrolytes. Check regularly in the blood, carbon dioxyl and blood pressure. Must ensure adequate drainage in patients clogged to urine gates from the bladder (such as prostate hypertrophy).

What to do when forgetting a dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using DiureFar 40, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Circulation: Reduce blood volume in the case of high -dose hypotension.

Metabolic: Water and electrolyte imbalance includes hypokalemia, hypoglycet hypoglycemia, hypoglycemia, blood calcium loss, chlorine alkaline infection.

Uncommon, 1/1000

Digestive: Nausea, vomiting, digestive disorders.

Metabolism: increased uric acid and gout.

Rare (ADR

Skin: skin rash, paresthesia, urticaria, itching, hemorrhage, peeling dermatitis, sensitive reaction to light.

Hypersensitivity reactions: vasculitis, interstitial nephritis, fever. Blood: Inhibiting bone marrow, leukopenia, thrombocytopenia, losing leukocytes, anemia.

Metabolic: Hyperglycemia, urinary glucose, pancreatitis and jaundice.

When encountering side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using DiureFar 40, you need to read the instructions for use and refer to the information below.

Contraindicated

DIUREFAR 40 contraindicated drug in the following cases:

Hypersensitivity to any ingredients of the drug;

allergies to Furosemid or with sulfonamid derivatives;

Reducing blood volume, dehydration (with or not accompanied by hypotension);

Hypotension of severe blood, severe hypoglycemia;

coma or money coma due to cirrhosis;

Kidney failure due to liver coma;

Renal failure has creatinine clearance

Addison disease, Digitalis poisoning;

Porphyrin metabolic disorders;

Lactating women;

Anaturia or kidney failure due to kidney or liver toxic drugs.

Caution when using

Monitor electrolytes, especially sodium and potassium, hypotension, gout, diabetes, kidney, liver failure. Avoid using patients with severe liver failure.

Dose reduction in the elderly to reduce the risk of toxicity with hearing.

When urine is small, it is necessary to compensate for the blood volume before taking the drug.

Be cautious when using Furosemid in children, especially when used for prolonged use. Must carefully monitor water and electrolytes.

Infants lacking a month when using Furosemid may be at risk of getting disease and arterioscleros.

Furosemid occupies Biliburin's place at the albumin position, must be used cautiously in children with jaundice.

Furosemid's clearance in infants is much slower than adults, half -life eliminated in plasma 8 times longer, must be calculated when using the dose repeated.

Be cautious of patients with prostate hypertrophy or difficult urine because they can promote urination.

Use Furosemid is considered unsafe in patients with porphyrin metabolism disorders, because it is often accompanied by an exacerbation.

In patients with parathyroid hygiene, Furosemid may cause muscle spasticity due to blood calcium.

In the lactose drug component, therefore be cautious in patients with rare genetic problems in galactose tolerance, lactase deficiency or glucose - galactose malabsorption syndrome.

The ability to drive and operate machinery

Reduce mental, dizziness and blurred vision, especially at the beginning of treatment, with dosage changes and in combination with alcohol.

Patients should know that if they are affected, they should not drive, operate machinery or participate in the activities where the effects can put themselves or others at risk.

Pregnancy and lactation

Pregnant women

Precautions when used and only used when considering the benefits and risks.

breastfeeding women

The drug is at risk of inhibiting milk, this case should stop breastfeeding.

Drug interaction

Other diuretic drugs: increase the effect of Furosemid. Potassium -keeping pills can reduce potassium loss when using Furosemide.

Antibiotics: Cephalosporin increases kidney toxicity, aminoglycosides increase toxicity to the ears and kidneys, Vancomycin increases ear toxicity.

Lithi salt: increases the level of lithium in the blood, can be toxic. Should avoid using if you cannot monitor the concentration of blood lithium.

cardiac glycosides: increase the toxicity of glycosides on the heart due to furosemide lowering blood potassium. Need to monitor blood potassium and electrocardiograms.

Non -steroid anti -inflammatory drugs: increases the risk of toxicity to the kidneys, reduces diuretic effects.

corticosteroid: Increased risk of reducing potassium, antagonism with diuretic effects.

Anti -diabetic drugs: reduce the effect of lowering blood glucose of anti -diabetic drugs. Need to monitor and adjust the dose.

Non -reducing muscle relaxants: increase muscle relaxation effect.

Anticoagulants: Increasing anticoagulant effects.

cisplatin: Increasing ear and kidney toxicity.

Hemotrogate medications: increase the effect of lowering blood pressure. If coordinated, the dose should be adjusted. Especially, when combined with enzyme inhibitors, angiotensin transfer, blood pressure may be severe.

Anti -epileptic drugs: Phenytoin reduces the effects of Furosemide, Carpamazepine reduces sodium blood.

Chloral Hydrate: causes blushing syndrome, tachycardia, hypertension, sweating.

Probenecid: reduces the kidney clearance of Furosemid and reduces the diuretic effect.

Central neurological inhibitors (chlorpromazin, diazepam, clonazepam, halothan, ketamin): increase the effect of reducing blood pressure.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

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