Diuresin SR 1.5mg Polfarmex treatment for hypertension (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Indapamid

Ingredient

Composition information	Content
Indapamid	1.5mg

Uses

indications

Diuresin SR is indicated in cases;

Treatment of idiopathic hypertension:

The drug can be used alone or in combination with other anti -hypertension drugs such as beta - adrenergic blockers, angiotensin conversion enzyme inhibitors, calcium blockers, or alpha blockers 1 - adrenergic. Indomamid can be informed or enhanced other anti -hypertension drugs.

Treatment of edema and salt keeping due to heart failure or other causes:

In severe, acute left heart failure, first use more powerful diuretic such as bumetanid or furosemid.

Pharmacological

indapamid is a diuretic sulfonamid, with indol nucleus, not belonging to the thiazid group. The drug has diuretic and anti -hypertension effects.

diuretic effect

like thiazid diuretics, indapamid increases sodium chloride secretion and water by inhibiting the reabsorption of sodium ion at the dilute segment of the distal tube in the kidney shell. Sodium and chloride excreted drugs and less, potassium and magnesium, thus increasing the urethra.

Long -term indapamid can cause mild metabolic alkaline infection, accompanied by hypokalemia and blood chlorine, in patients with hypercalcemia, indapamid reduces calcium secretion through urine. Seeds of thiazid diuretics, indapamid, with treatment, can reduce uric acid excretion through urine. There have been reports on some patients, hyper uric acid hyperkemis accompanied by symptoms, when using indapamid.

Anti -blood pressure effect

The anti -hypertension effect of indapamid has a major mechanism outside the kidney. This mechanism increases the reaction of blood vessels to the vascular tonsils back to normal and reduces the peripheral artery resistance.

The mechanism of blood vessels is explained by reducing the shrinkage of blood vessel smooth muscles due to changing the exchange of ions through the membrane, especially calcium ions, by vasodilation due to the synthesis of vascular dilatation, lowering blood pressure such as PGE2, PGI2, finally by enhancing Bradykinin vasodilation effect.

has proven the anti -hypertension effect of the drug has a mechanism in the kidneys in that the drug still maintains the anti -hypertension effect in people with hypertension without kidney function.

With a daily dosage of 1.5 mg, indapamid has a long -term anti -hypertension effect on people with hypertension. Research on related dosage - effects has proved that with the daily dose of 2.5 mg daily, anti -hypertension effects reach the maximum level, while diuretic effects have no clinical manifestations.

Metabolic effect

Indopamid shows little effect on triglyceride concentration, total cholesterol, high density lipoprotein (HDL), lipoprotein very low density (VLDL) and low density lipoprotein (LDL) in serum, although the data when long -term treatment is limited. Blood glucose usually does not change, but there has been an increase in blood glucose in some patients taking medication.

Dynamic pharmacokinetics

indapamid are absorbed quickly and completely through the stomach - intestines. Food or antacids almost does not affect the absorption of the drug. After drinking, the blood peak concentration is about 2 to 2.5 hours.

indapamid prefers lipids and is widely distributed in the body's organizations. About 71 - 79% of the drug is associated with plasma proteins. The drug is also attached to the carbon dioxide in the red blood cells. Half -life of indapamid elimination is about 14 to 18 hours in adults and adults, normal kidney function, in people with impaired renal function, half -life of the drug does not last.

Indapamid is strongly metabolized in the liver, mainly into glucuronid and sulfate agents. About 60% of the drug excreted in the urine within 48 hours, only 7% of the drug excreted in the form of the body. About 16 - 23% of the drug excreted into the feces, through the biliary tract. Hematopathy does not eliminate indapamid from circulation.

Before taking Diuresin SR 1.5mg Polfarmex treatment for hypertension (3 blisters x 10 tablets)

How to use

diuresin sr is oral, oral in the morning.

Dosage

Treatment of hypertension

The dose for adults is 1 tablet of 1.5 mg indapamid daily, drink in the morning. The effects of indapamid growth gradually, blood pressure can continue to decrease and only achieve maximum effect after months of treatment.

No need for a dose greater than 2.5 mg of indapamid because of the anti -hypertension effect does not increase but the diuretic effect is clearly revealed.

Use indapamid simultaneously with other anti -hypertension drugs with better blood pressure results and the proportion of patients responding to an increase in hypertension compared to patients taking one, but also need to notify patients when combined with other anti -hypertension drugs may increase the ability to lower vertical blood pressure.

Recently, the recommended dose of 1.5 mg/day/1 time, giving good results and few side effects.

Treatment

The adult dose is 3.0 mg of indapamid, used once a day and after 1 week can increase to 4.5 mg/time/day. Currently, there are stronger diuretics such as bumetanid or Furosemid.

Note: Inexperienced use of indapamid for children.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Overdose treatment is symptomatic treatment, no specific antidote.

If an acute overdose is overdose, gastric lavage or vomiting should be carried out immediately. Need to carefully assess water and electrolyte balancing after gastric lavage. Treatment support maintaining respiratory and circulatory functions.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Diuresin SR, you may experience unwanted effects (ADR).

Increasing urinary tract with indapamid may cause an electrolyte disorder. In the process of using indapamid, there may be a decrease in potassium, sodium hypoglycemia or alkaline infection due to hypoglycemia.

Hypotension is too high doses, and is an unwanted effect of IndaPamid at 3 - 7% of the patient taking the drug. Sometimes hypoglycemia; Sodium hypoglycemia develops dull in long -term treatment, no symptoms and mildly. However, there may also be severe hypoglycemia, but rare.

Under 5% of patients using indapamid shows signs of increased serum creatinine but not clinically important. Some cases of hyperuricemia and very rare cases lead to clinical gout, unless there is a history of gout or a family that has a direction of gout, or has chronic kidney failure.

Hyperglycemia and urinary tract appear less than 1% of patients using indapamid, due to secondary results of hypokalemia. Using indapamid also leads to reduction of glucose tolerance in a few patients.

In addition to electrolyte and metabolic disorders, indapamid also has the following unwanted reactions:

Common, ADR> 1/100

General: fatigue, muscle weakness.

Cardiovascular: Hypotenary pressure vertical, brushing chest.

Blood: platelet reduction, loss of granulocytes.

indapamid, with treatment dose, often well tolerated and have little unwanted effects. Dosage reduction sometimes, may lower the rate of appearance and severity of unwanted effects. About 2 - 10% of the patient using indapamid must stop using the drug due to unwanted reactions. Because indapamid can cause electrolytes, it is necessary to periodically determine the concentration of electrolytes in serum especially for sodium, potassium, chloride and bicarbonate ions, for those who are taking the drug.

To prevent or treat hypokalemia, it is necessary to take measures to maintain normal serum concentrations and supplement potassium if needed. Hemotentic reduction room is especially important when using indapamids in large doses (> 5 mg daily) simultaneously with cardiac glycosides or potassium loss drugs such as corticosteroids, corticotropine, or for patients with cirrhosis or hyperloston and for cases where potassium -reducing is considered a risk, such as a history of ventricular arrhythmia.

Periodically determine the concentration of electrolytes in serum is especially important for patients with vomiting, diarrhea, patients who are infusion, people who are sick can cause disorders of electrolytes such as heart failure, kidney disease and patients who eat light diet.

Patients with edema may increase the risk of developing sodium hemorrhage due to thin blood. Often treated with restrictions on the body (500 ml/day) and stop using the drug.

In case of hyperuricemia and gout, it is recommended to use hyperuric waste.

Notify the doctor the unwanted effects when taking the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

DIRESIN SR is contraindicated in the following cases:

The new patient has a stroke.

Be cautious when used

must be used with indepamids in people with severe kidney disease, because plasma volumes are reduced and the rate of glomerular filtration may promote nitrogen hypercass. If the renal damage progresses, it is necessary to stop using indapamid. Caution should be used when using indapamid for patients with impaired liver function or there is a progressive liver disease, especially when there is a decrease in serum potassium, due to water and electrolyte imbalance due to drugs that can promote liver coma.

During indapamid treatment, periodic blood sugar concentration must be periodically determined, especially in patients who have been or suspected of diabetes.

like thiazid diuretics, be cautious when using indapamid in patients with hyperthyroidism or thyroid diseases. If in the process of using indapamid appears hypercalcemia and decreased blood phosphate, it is necessary to stop the drug before testing the parathyroid function. Because thiazid diuretics can worsen the whole body lupus erythema, this ability can occur for indapamid.

For patients with sympathetic nerve removal surgery, the use of indapamid must also be cautious because the hypotension effect of the drug can increase in these patients.

The ability to drive and operate machinery

Individual reactions related to arterial hypotension may occur in some patients. Therefore, the ability to drive or operate machinery may be obstacles.

Pregnancy

Research on animals shows that drugs are not toxic to fetal development. However, there is no complete and complete research on pregnant women, so it is not allowed to use indapamids for pregnant women except for the benefit of the use of drugs greater than any potential risk.

Breastfeeding period

It is unknown whether indapamid is distributed in milk or not. If it is necessary to use medication for breastfeeding, you must stop breastfeeding.

Drug interaction

Do not use indapamid in combination with other diuretics because it can cause hypokalemia and hyperuricemia. Like thiazid diuretics, do not use indapamid simultaneously with lithium because diuretics reduce the removal of the kidneys for lithium, thus risk lithium poisoning.

IndaPamid reduces artery response to vasoconstrictors such as noradrenalin, but the decrease is not enough to prevent the treatment effect of noradrenalin.

Storage

In a cool, dry place, avoid light, at temperatures below 30 ° C.

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