Dobutane Spray Unison Spray Analgesic, anti -inflammatory in musculoskeletal and joint disease (60ml)

Dosage form Bottle x 60ml
Specifications Diclofenac
Ingredient Unison Laboratories

Ingredient

Composition information	Content
Diclofenac	1%

Uses

indications

Dobutane Spray is indicated in the following cases: treatment for pain and anti -inflammatory in different cases in musculoskeletal and joint diseases such as rheumatoid arthritis, osteoarthritis, vertebral arthritis, joint disorders such as tendonitis, soft tissue disorders such as sprains and muscle stretching.

Pharmacokic

diclofenac is a derivative of phenylacetic acid, which is an anti -inflammatory drug - steroid. The effect of non -anti -inflammatory drugs - steroids is due to strong inhibition of the activity of cyclo - oxygenase is the substance involved in the biosynthesis of prostaglandins and thromboxanes from Arachidonic acid, prostaglandin plays an important role in the process of pain and inflammation. Therefore, the drug has anti -inflammatory and analgesic effects. Combining the anti -inflammatory and analgesic effects of NSAID creates special usefulness in the treatment of diseases with pain and/or inflammation, including joint disorders such as arthritis, chronic arthritis, spinal degeneration, joint disorders and soft tissue.

Dynamic pharmacokinetics

diclofenac is absorbed through the skin. At the concentration of treatment, more than 99% of the drug is associated with plasma proteins. DiClofenac penetrates the fluid liquid, where the drug can maintain the concentration even when plasma concentration decreases. DiClofenac can be distributed through breast milk but researchers assess the amount of distribution too small to be harmful to infants breastfeeding.

Selling plasma waste time is about 1-2 hours. Diclofenac is converted into 4 - hydroxydiclofenac, 5 - hydroxydiclofenac, 3 ' - hydroxydiclofenac and 4, 5 - hydroxydiclofenac. The drug is then excreted in the form of associated with glucoronide and sulphate, mainly through urine (about 65%) and also through bile (about 35%).

Before taking Dobutane Spray Unison Spray Analgesic, anti -inflammatory in musculoskeletal and joint disease (60ml)

How to use

Dobutane Spray is a spray directly in the inflammatory position.

Dosage

Spray directly in the position of inflammatory, pain 3-4 times/day: If used in the treatment of chronic osteoarthritis, it is necessary to re -evaluate after the treatment period of 14 or 28 days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

In case of swallowing Dobutane Spray, which leads to significant side effects, should use common treatments often applied to treat poisoning with NSAID drugs.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not use double the prescribed dose.

Side Effects

When using Dobutane Spray, you may experience unwanted effects (ADR).

Some mild skin reactions such as rash, itching may appear in patients treated with diclofenac. The more severe skin reactions can be seen such as blistering dermatitis, multi -rash.

Instructions on how to handle ADR

When experiencing side effects of Dobutane Spray, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Dobutane Spray is contraindicated in the following cases:

Non -steroid anti -inflammatory drugs (NSAIDs) should be used carefully in infection patients, because symptoms such as fever and inflammation may be covered, also need to be used cautiously in asthma patients and allergic diseases.

NSAIDs are not used for patients with a history of allergies to aspirin or other NSAIDs, in people who are attacked by allergic symptoms such as asthma, edema, urticaria or rhinitis when taking aspirin or any other NSAIDs.

Caution when used

should be cautious and monitor when prescribing patients with hemorrhage disorders, hypertension and kidney failure, liver, or impaired heart function. Patients who are being treated with some NSAID may need to be monitored with the development of blood, kidney, liver or eye disorders. Some NSAIDs may affect thyroid function tests due to reducing serum - thyroid hormone levels.

Children

There is no enough data on efficiency and safety for children and young people under 14 years old. However, the use of Dobutane Spray for children and teenagers with age under 14 years old is often inappropriate.

Older people

Should be cautious when using NSAID drugs for the elderly. The bleeding of aspirin and other NSAIDs is more common in the elderly, which can lead to death or other serious consequences. NSAIDS is also a special danger for patients with heart disease or kidney failure, which can once again put elderly patients at a special risk.

The ability to drive and operate machinery

The use of diclofenac sprays in addition to the skin does not affect the ability to drive and operate machinery.

Pregnancy

Avoid using NSAIDs during pregnancy, unless the benefits of treatment greater than the risk. NSAIDs should be avoided in the last 3 months of pregnancy because the use is associated with the risk of fetal arteriosclerice in the uterus and may occur prolonged pulmonary hypertension in babies. In addition, the time of labor start may be delayed and the labor period may increase.

The period of breastfeeding

NSAID should be used carefully during breastfeeding. DiClofenac is allocated into breast milk but with the amount of thought that is too small to be harmful to infants to breastfeed.

Drug interaction

Notable interactions related to NSAIDs include:

Increase the effects of oral anticoagulants (especially when used with Opeopazone and Phenylbutazone) and increase the concentration of lithium, methotrexate and heart glycoside in serum.

The risk of kidney toxicity may increase when treated simultaneously with ACE inhibitors, cyclosporine, tacrolimus or diuretics, lighting on the kidney function can lead to reducing the secretion of some drugs. When treated simultaneously with ACE inhibitors and potassium -keeping pills can increase the risk of hyperkalemia. The anti -blood pressure effect of anti -blood pressure drugs including ACE inhibitors, beta blockers and diuretics may be reduced.

seizures may occur due to interaction with the Quinolones group.

nsaids can increase the effects of phenytoin and anti -diabetes drugs Sulphonylurea.

The effect of NSAIDs may increase when used simultaneously with Moclobemide.

should be avoided simultaneously with another NSAID (including aspirin) because it may increase the risk of side effects.

Storage

Store at temperatures below 30 ° C.

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