Dofluzol 5mg Domesco medicine treats dizziness in the vestibular, prevention of migraine (100 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Flunarizine
Ingredient Vestibular disorders, migraine, dizziness

Ingredient

Composition information	Content
Flunarizine	5mg

Uses

indications

Dofluzol 5 mg drug is indicated in the following cases:

Preventive migraine prevention. The drug prevents calcium overload in the cell, by reducing overflow overflow through the cell membrane. Flunarizine does not act on myocardial contraction, does not inhibit the atrial or atrial node, does not increase the heart frequency, does not have anti -hypertension effect.

Dynamic pharmacokinetics

absorption: Flunarizine is absorbed through the gastrointestinal tract

Distribution: Flunarizine is associated with plasma protein> 99%. Large distribution volume, about 78 l/kg in healthy people and about 207 l/kg in epilepsy patients, with high distribution levels outside the circuit. The drug quickly passed through the blood -n -flab, the concentration of the brain in the brain about 10 times higher than the plasma concentration.

Metabolism: Flunarizine is converted through the liver into at least 15 metabolites. The main metabolic line is through CYP2D6.

Elimination: Flunarizine excreted mainly through biliary feces in constant form and metabolites. After taking 24–48 hours, about 3–5% of the dose is eliminated in the form of unchanged and metabolites, and

Recommended dose: Flunarizine's plasma concentration achieves a stable state after about 8 weeks of repeated dose, used once a day, and about 3 times higher than the single dose.

Before taking Dofluzol 5mg Domesco medicine treats dizziness in the vestibular, prevention of migraine (100 tablets)

How to use

oral, drinking drugs in the evening.

Dosage

Preventive Preventive:

Starting dose:

Adults ≤ 65 years old: 2 capsules x 1 time/day. If after 2 months there is no significant improvement, the patient is considered as not responding and should stop treatment.

Maintain treatment: If the patient responds well and if the treatment is needed, the dose should be reduced to 5 days with the same daily dose and 2 days off per week. If treatment is maintained successfully and well used, it may stop treating for 6 months and only start treatment if recurrent.

Dizziness:

The daily dose is similar to migraine, but the starting treatment only lasts until the symptoms are controlled, usually less than 2 months. If there is no significant improvement after 1 month for chronic dizziness, 2 months for dizziness, patients are considered not responding and should stop treatment.

Dosage in patients with liver failure: Because the drug is metabolized to a large level of the liver, the dosage should be adjusted in these patients. Starting dose: 5 mg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? There are several cases of acute overdose (high dose to 600 mg oral 1 time) The stone is reported, observing the symptoms: drowsiness, fast heart rate, agitation.

Management: There is no specific antidote. For 1 hour after overdose, gastric should be washed. Can use activated carbon if appropriate.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Dofluzol 5 mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Central nervous system: drowsiness, fatigue.

Other ADR: Increase appetite, weight gain.

Uncommon, 1/1000

Central nervous system: depression, pagoda symptoms (slow movement, stiffness, restless sitting, dysplasia, tremor).

digestive: dry mouth.

Rare, ADR

Digestive: Nausea, stomach pain.

Other ADR: Increase milk.

Unknown frequency

Central nervous system: Anxiety.

Muscle muscle: muscle pain.

DA: rash.

Instructions on how to handle ADR

When unwanted effects occur, stop using Flunarizine, symptoms will cure completely or partially reduce. Conduct symptomatic treatment and support if needed.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

5 mg dofluzol drugs in the following cases:

Hypersensitivity to the ingredients of the drug.

Porphyrin metabolic disorders.

Pre -history of depression, Pakinson or other pagoda disorders.

Be cautious when using

treatment with flunarizine may increase symptoms of depression, foreign tapes and cause Parkinson's syndrome, especially in patients at risk as elderly people. Therefore, caution should be used in these patients.

In some rare cases, fatigue may increase during treatment with flunarizine. In this case, treatment should be stopped. Do not exceed the prescribed dose. Patients must be regularly examined, especially in the maintenance stage, to be able to detect foreign or depression symptoms early and stop treatment. If in maintenance treatment does not work effectively, stop treatment.

Patients with galactose tolerance problems, patients with enzyme deficiency lapp lactase or malcose -galactose should not be used.

The ability to drive and operate machinery

Because drowsiness can occur, especially at the beginning of treatment, should be cautious in activities such as driving or operating machinery.

Pregnancy

There has been no research to confirm the safety of flunarizine when used in pregnant women. Therefore, do not use this drug in pregnant women, unless the benefits are superior to the risk of pregnancy.

Breastfeeding period

It is unknown whether Flunarizine is distributed into human milk or not. Consider or avoid using drugs during breastfeeding or taking medicine and stopping breastfeeding.

Interactive drug

alcohol, sedative, sleeping pills when sharing Flunarizine, increasing the side effects of drowsiness. Flunarizine is not contraindicated in patients taking beta blockers.

Flunarizine's

pharmacokinetics are not affected by Topiramate. The stable pharmacokinetic state of Topiramate is not affected by flunarizine.

Long -term use flunarizine does not affect the concentration of phenytoin, carbamazepine, valproate or phenobarbital. Flunarizine's plasma concentrations are usually a little lower in epilepsy patients using these epilepsy drugs compared to healthy people using the same dose. Carbamazepine, Valproate and Phenytoin's plasma proteins are not affected by simultaneous use of flunarizine.

Storage

Store in a dry place, avoid light, temperature below 30 ° C.

Storage in the original packaging of the drug.

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