Dogastrol 40mg Southeast treatment of stomach diseases (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Pantoprazol
Ingredient Gastrointestinal ulcers, gastroesophageal reflux, Zollinger-Elison syndrome

Ingredient

Composition information	Content
Pantoprazol	40mg

Uses

Indications

Dogastrol drugs are indicated in the following cases:

Treatment of gastroesophageal reflux. Cortic acid secretion in the stomach by blocking specific proton pumps of the cell.

Pantoprazole is converted into activity in the acidic environment in the cell into, where it inhibits the H+, K+ -atpase enzyme, ie the final stage in the production of hydrochloric acid in the stomach. The inhibition depends on the dosage and affects both basic and stimulating acid excretion. In most patients, from symptoms will be achieved within 2 weeks. Like other proton pump inhibitors and H2 receptor inhibitors, pantoprazole treatment reduces the acidity in the stomach and thus increases gastrin corresponding to reducing acidity. Gastrin increase can recover. Because Pantoprazole is linked to a distant enzyme at a cell receptor level, it can inhibit the excretion of independent hydrochloric acid excretion with the stimulation of other substances (acetylcholine, histamine, gastrin).

pharmacokinetics

Absorption

Pantoprazole is quickly absorbed and reaches a maximum concentration in plasma even after a single dose of 40 mg. On average, about 2.5 hours/year, the maximum concentration in serum is about 2-3 µg/ml, and these values are constant after use many times.

Pharmacokinetics does not change after one use or repeat. In the dose of 10 to 80 mg, the plasma dynamics of Pantoprazole are linear after oral and intravenously.

Absolute bioavailability of pills is about 77%. Eating at the same time does not affect AUC, the maximum concentration in the serum and thus bioactive. Only the change of late time will increase when eating simultaneously.

Distribution

Linking to Pantoprazole's serum protein is about 98%. Distribution volume is about 0.15 l/kg.

Metabolism

This substance almost only metabolizes in the liver. The main metabolic path is methyl by CYP2C19 with the later sulphate combination, other metabolic paths including oxidation by CYP3A4.

Elimination

The semi -canceled time is about 1 hour and the clearance is about 0.1 l/h/kg. There are several cases of slow eliminated subjects. Due to the specific cohesion of Pantoprazole with the cell's proton pump, the semi -disposal time is not correlated with the much longer -effect time (acid secretion).

The excretion through the kidneys is reflected in the main excretory path (about 80%) for the metabolites of Pantoprazole, the rest is eliminated through feces. The main metabolic substance in both serum and urine is Desmethylpantoprazole in conjugated with sulphate. The sale time of the main metabolite (about 1.5 hours) is not much longer than Pantoprazole.

Before taking Dogastrol 40mg Southeast treatment of stomach diseases (3 blisters x 10 tablets)

How to use

Dogastrol medicine used once a day in the morning, before or after meals. Antacids can be taken simultaneously with this drug.

Because Pantoprazole is destroyed in the acidic environment, it must be used in the form of tablets in the intestine. When taking Pantoprazole, you have to swallow the whole tablet, not to break, chew or break the pill. Must have a full week of treatment.

Dosage

Gastroesophageal reflux disease - esophagus: Take 20 - 40mg daily in the morning for 4 weeks, can increase up to 8 weeks if necessary. In people with esophageal ulcers after 8 weeks of treatment, can extend the treatment for up to 16 weeks.

Maintain treatment: 20 - 40 mg per day. Safety and efficiency of maintenance dose for over 1 year has not been determined.

Treatment of benign stomach ulcers: Take 1 time 40mg per day for 4 - 8 weeks.

duodenal ulcer: Take 1 time a day 40 mg, for 2-4 weeks.

To eradicate Helicobacter pylori, it is necessary to combine Pantoprazole with 2 antibiotics in the treatment mode using 3 drugs in a week. Depending on the type of drug resistance, it is possible to follow the following combination diagrams to kill Helicobacter pylori:

regimen 1: 2 times a day x (1 pantoprazole + 1000 mg amoxicillin + 500 mg Clarithromycin) x 7 days.

regimen 2: 2 times a day x (1 pantoprazole + 1000 mg metronidazol + 500 mg Clarithromycin) x 7 days.

regimen 3: 2 times a day x (1 pantoprazole + 1000 mg of amoxicillin + 500 mg of metronidazole) x 7 days.

Preventive treatment for gastrointestinal ulcers due to nonsteroidal anti -inflammatory drugs: Take 1 time 20mg.

Treatment of pathological acid secretion in Zollinger - Ellison syndrome: Take the starting dose of 80 mg once a day, then adjust according to the patient's response (the maximum dose of 40 mg/day). The dose can be increased to 240 mg daily. If the daily dose is greater than 80 mg, then divided into 2 times a day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? The signs and symptoms of the overdose may be: fast heartbeat, vasodilation, sleep, confusion, headache, blurred vision, abdominal pain, nausea and vomiting.

Handling: gastrointestinal, using activated carbon, symptomatic treatment and support.

Monitor the activity of the heart, blood pressure. If vomiting is prolonged, water and electrolytes must be monitored. Because pantoprazole is strongly attached to plasma proteins, the method of separation does not eliminate the drug.

What to do when forgetting a dose? If it is nearly time to take the next dose, skip the forgotten dose and take medicine at the next recommended dose. Do not take double dose to compensate for the forgotten dose.

Side Effects

When using Dogastrol, you may experience unwanted effects (ADR). Overall, Pantoprazole is well grated both for short -term and long -term treatment. Proton pump inhibitors reduce acidity in the stomach, which may increase the risk of gastrointestinal infections.

Common, ADR> 1/100

Body: tired, dizzy, headache

Body: weakness, dizziness, dizziness, insomnia.

Systemic: sweating, peripheral edema, discomfort, anaphylaxis. Or inhibition, tinnitus, tremor, confusion, hallucinations, paresthesia. Blood.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Dogastrol drugs are contraindicated in cases of hypersensitivity to any component of the drug.

Caution when using

before using pantoprazol as well as other drugs inhibiting proton pump for people with stomach ulcers, which must eliminate stomach cancer because the drug can cover symptoms or slow cancer diagnosis.

Be careful when using pantoprazol in people with liver disease (acute, chronic or history). The serum concentration of the drug may increase slightly and mitigate the excretion; But do not need to adjust the dose. Avoid use when cirrhosis, or severe liver failure. If used, the dose should be reduced or given 1 time a day. Must monitor liver function regularly. Use carefully in people with kidney failure, the elderly.

The ability to drive and operate machinery

No report.

Pregnancy

There is no complete study when used in humans during pregnancy. Animal studies have shown Pantoprazol through the placenta fence, but has not observed the monster effect. Doses of 15 mg/kg slowed the development of bone in fetus. Only used when really necessary during pregnancy.

Breastfeeding period

whether it is unknown whether pantoprazol is excreted in human milk or not. However, Pantoprazol and its metabolites excrete on mouse milk. Based on the potential of cancer in the mouse of Pantoprazol, it is necessary to consider stopping breastfeeding or stopping the drug, depending on the benefit of Pantoprazol with the mother.

Drug interaction

Although Pantoprazol is metabolized through the liver enzyme enzyme system in the liver, but does not inhibit or activate the enzyme activity. There is no clinical interaction that is noticeable about the interaction between Pantoprazol and conventional drugs such as diazepan, phenytoin, nifedipin, theophylin, digoxin, warfoxin or oral contraceptive pills.

Like other proton pump inhibitors, Pantoprazol can reduce the absorption of some drugs that their absorption depends on the stomach pH such as ketoconazole, iTraconazole. Severe muscle pain and bone pain can occur when using methotrexat along with pantoprazol.

Storage

In a dry place, temperatures below 30 ° C, avoid light.

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