Dogmaskib drugs 50mg capsules treatment of acute and chronic schizophrenia (2 blisters x 15 tablets)

Dosage form Box of 2 blisters x 15 tablets
Specifications Sulpiride
Ingredient Kern Pharma S.L - Spain

Ingredient

Composition information	Content
Sulpiride	50mg

Uses

indications

Dogmaskib drugs are indicated in the following cases:

Acute and chronic schizophrenia (prescribed by a specialized physician). Short treatment of agitated and aggressive states in acute and chronic psychotic state. Sulpidi can be considered as an intermediate medication between neuroleptic and antidepressants, because sulpides have both of these effects. Sulpidi is mainly used to treat psychosurine diseases such as schizophrenia. The mood increases after a few days of treatment, accompanied by losing all the frantic symptoms of the disease. Sulpidi does not cause drowsiness and loss of emotions like when using classic neuroleptics such as phenothiazin or butyrophenon. High doses of sulpiders control the positive symptoms of schizophrenia, but low doses have the effect of active and agile for people with indifferent schizophrenia, cowering without contact with society. Although there are some characteristics of classic neuroleptics, sulpides are different from those drugs in terms of chemical structure and does not cause the position to keep the posture, does not affect the adenylcyclase system sensitive to dopamine, does not affect the transition of noradrenalin and 5-HT, almost no anti-cholinesterase effect, does not affect Muscarinic or GABA receptors.

Dynamic pharmacokinetics

Used by oral, Sulpiride is absorbed in 4.5 hours; The peak concentration of sulpiride in plasma is 0.25 mg/l after taking the capsule 50 mg.

The bioavailability of oral form is from 25 to 35%, there may be significant differences between one person and others; Sulpiride concentrations in plasma are linearly related to the dose.

Sulpiride is quickly diffused to tissues, especially to the liver and kidney; Poor brain diffusion, mainly to the pituitary gland.

The ratio attached to plasma Proteine is less than 40%; The distribution coefficient to red blood cells and plasma is 1. The excretion of breast milk is estimated to be 1/1000 of the daily dose. The figures made on animals by sulpiride are marked (C14) show that the excretion through the placenta is very poor. In contrast to animal records, Sulpiride is very little metabolized in humans; 92% of sulpiride dose used by intramuscularly found in urine in constant form.

Sulpiride pharmacology includes the absorption phase, followed by the distribution phase, followed by the elimination stage. The half -life of plasma elimination is 7 hours; The distribution volume is 0.94 l/kg. Total clearance is 126 ml/min.

Sulpiride is excreted mainly through the kidneys, thanks to the filtration process in the glomerular. The renal clearance is usually close to the total clearance.

Before taking Dogmaskib drugs 50mg capsules treatment of acute and chronic schizophrenia (2 blisters x 15 tablets)

How to use

oral tablets. Take the tablet with a glass of water.

Dosage

Adults:

Symptoms of negative mental mental illness: Start oral 200 - 400mg/time, twice a day, if necessary, a maximum dose of 800mg/day.

Positive symptoms of schizophrenia: 400mg/time, 2 times a day. Gradually increase the dose to up to 1200mg/time, drink 2 times a day.

Symptoms of yin and positive combination: 400 - 600mg/time, 2 times a day.

Children:

Children over 14 years old: Take 3 - 5mg/kg/day

Children under 14 years of age: No instructions.

Elderly:

Dosage for the elderly is the same as adults, but the starting dose is always low and increasing.

Starting 50 - 100mg/time, 2 times a day, later increasing to effective dose.

People with kidney failure:

Must reduce the dose or increase the distance between drug use depending on the clearinine clearance.

Creatinine clearance 30 - 60ml/minute: use the dose equal to 2/3 of the normal dose. 2 and 3 times compared to normal.

However, in case of medium and severe renal failure should not use sulpides, if possible.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? In some cases: vibration syndrome is very serious, coma.

The treatment is limited to the treatment of symptoms.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using Dogmaskib, you may experience unwanted effects (ADR) such as:

Sulpidi is well tolerated. When using the dose of treatment, ADR is usually lighter than other anti -psychotic drugs.

Common, ADR> 1/100:

Neuroscope: Insomnia or drowsiness.

Neuroscope: excessive stimulation, extracurricular syndrome (restless sitting, crooked neck, eye rotation), Parkinson's syndrome.

Endocrine: Big breasts in men. ADR:

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Dogmaskib drugs contraindicated in the following cases:

Hypersensitivity to sulpidi or any ingredients of the drug. breast).

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Be cautious when using sulpides because the drug can cause malignant syndrome caused by neuroleptics. During treatment, if high fever is not clear, it is necessary to stop the drug immediately because high fever may be a manifestation of malignant syndrome due to neuroleptics.

Sulpidi extends the QT range, depending on the dose. This effect increases the risk of heavy arrhythmia, especially the top, especially when there is a bradycardia

Be cautious when using sulpides for the elderly, especially when dementia, when there are risk factors for stroke, brain vessels because they are susceptible to hypotension, easy to fall, sleepy, sleepy and extra -tower effects. The risk of death often increases when using anti -psychotic drugs at this age.

Must monitor blood glucose for people with diabetes or risk diabetes at the beginning of sulpida treatment.

In cases of renal failure, sulpider dose is needed and increased monitoring. If the renal failure is severe, it is recommended to treat each interrupt batch.

Need to strengthen monitoring of the following objects:

People with epilepsy because they are likely to be lowered.

The effect of the drug on the ability to drive and operate machinery

The drug can cause drowsiness, fall asleep, so be careful for drivers or operating machines.

Use drugs for women during pregnancy and lactation

pregnancy:

Restricted use during pregnancy and dose to be reduced at the end of pregnancy.

Infants: Need to monitor neurological functions (and digestion in case of combination with vibration anti -vibration drugs).

breastfeeding period:

The excretion of breast milk is estimated to be 1/1000 of the daily dose.

Follow the instructions from the doctor. The drug should only be used when the benefits are out of risks.

Drug interaction

levodopa: There is a similar opposition between Levodopa and sedative drugs.

In the event of a peripheral syndrome caused by neurolysis, not levodopa (due to dopaminergic receptors have been sealed by neuroleptic drugs), which should be used for anti -cholinergic drugs.

In patients with paralysis (Parkinson) treated with levodopa, in case of need to be treated with neuroleptics, should not continue to use Levodopa because it can worsen mental disorders and can affect the receptors that have been sealed by neuroleptics.

Caution when coordinating:

alcohol: Alcohol can increase the sedative effect of sedative.

Avoid drinking alcohol and alcohol -containing drugs or drinks.

Note when coordinating:

High blood pressure drug: Increases the effect of lowering blood pressure and can cause posture hypotension (due to the co -effect).

Other central neurological inhibitors: Antidepressants have sedative effects, antihistamine H1 drugs have sedative effects, barbiturate, sedative drugs, clonidine and drugs with them, sleeping pills, methadone: Increasing central neurological inhibition, can cause bad consequences, especially in people who have to drive or control machines.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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