Dogwazin Thanh Nam treats anxiety symptoms, severe behavioral disorders (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Sulpiride
Ingredient Anxiety, schizophrenia, autism

Ingredient

Composition information	Content
Sulpiride	50mg

Uses

indications

Dogwazin 50 mg is indicated in the following cases:

Treatment of short -term symptoms of anxiety in adults in case of failure with normal treatment.

Serious behavioral disorders (agitated, self -injuries, repetition of machines) in children over 6 years old, especially in autism syndrome.

Pharmacology

Sulpiride belongs to the benzamid group, which has an anti -mental disorder effect through the selective block of Dopamine D2 receptors. Sulpiride can be considered as an intermediate medication between neuroleptics and antidepressants, because sulpiride has both of these effects. Sulpiride is mainly used to treat psychosis such as schizophrenia.

Sulpiride does not cause drowsiness and loss of emotions like when using classic neuroleptics like phenothiazin or butyrophenon.

Dynamic pharmacokinetics

Sulpiride slowly absorbed through the gastrointestinal tract, low bioavailability and depending on the individual. The peak concentration of Sulpiride is reached from 3 to 6 hours after taking 1 dose. Quick distribution into tissues, through breast milk but through poor brain barriers. The drug is linked to low plasma proteins (

Before taking Dogwazin Thanh Nam treats anxiety symptoms, severe behavioral disorders (3 blisters x 10 tablets)

How to use

oral medication.

Dosage

should take the lowest dose effectively. In treatment, starting low doses then gradually increasing.

Adults:

Treatment of short -term symptoms of anxiety in case of failure with normal treatment: daily dose: 50 - 150 mg (1 - 3 capsules) for up to 4 weeks.

Children over 6 years old:

Serious behavioral disorders (agitated, self -injuries, machinery restorations), especially in autism syndrome: Daily dose: 5 to 10 mg/kg.

In children, the form of oral solution is better adjusted.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? When an overdose may be disturbed with muscular disorder in the tongue and jaw. Some people have worse Parkinson's syndrome, and neurolithic syndrome. Sulpiride eliminates partially through hemolysis.

Management: Sulpiride has no specific antidote. Symptomatic treatment. Cardiovascular respiratory resuscitation, continuous monitoring until recovery (prolonged QT risk and ventricular arrhythmia). If a severe surgeon syndrome appears, a cholinergic drug may appear.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Dogwazin 50 mg, you may experience unwanted effects (ADR).

When using the dose of treatment, Sulpiride's undesirable effect is usually lighter than other anti -psychotic drugs.

Common: Endocrine disorders cause hyperlactin blood prolactin; mental disorders causing insomnia; The nervous system disorder causes drowsiness, the surgeon syndrome is partially reduced when taking Parkinson Cholinergic, Parkinson, Run, restlessness; digestive disorders cause constipation; liver disorder causes liver enzyme increased; Disorders of skin or subcutaneous tissue causes nodules on the skin; reproductive system disorders and mammary glands cause a lot of milk secretion; General disorders causing weight gain.

Uncommon: Hematology and lymphatic systems cause leukemia; The nervous system disorders cause muscle tone, movement disorders, muscle disorders; Vascular disorders cause vertical hypotension; Gastrointestinal disorders cause salivation, reproductive system disorders and mammary glands that cause amenorrhea, helplessness or apathy.

Rare: Nervous disorders cause eye vortex; Cardiovascular disorders cause ventricular arrhyths such as torsion, ventricular tachycardia, can lead to ventricular vibration or cardiac arrest.

Unknown frequency: Hematological disorders and lymphatic systems cause neutropenia and grain leukocytes; Anaphylactic immune system disorders: urticaria, anaphylaxis; mental disorders causing confusion; The nervous system disorders that cause malignant syndrome of neuroleptics are likely to cause death, reduce movement, late movement disorders have been observed with all neuroleptics in prolonged treatment: Inefficient cholinergic Parkinsonian treatment or more aggravating, convulsions; Nutrition metabolic disorders cause hypoglycemia, anti -hormonal secretion syndrome inappropriate; Cardiovascular disorders cause extension of QT, sudden death; Vascular disorders cause venous embolism, pulmonary embolism, deep vein thrombosis, hypertension; respiratory disorders, chest and mediastinum causing inhaled pneumonia (mainly combined with other central neurological inhibitors); Hepatic disorders cause damage to liver cells, cholestas or mixture; Pregnancy, birth and birth cycle appeared weaning syndrome in newborns; Reproductive disorders and mammary glands cause large breasts.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindications:

Dogwazin 50 mg contraindicated in the following cases:

Hypersensitivity to sulpiride and other ingredients of the drug.

adrenal marrow, know or doubt.

Granting porphyrin metabolism disorders.

Collaborate with Parkinson -non -resistant dopamin -operating hosts (Cabergolin, Quinagolid), Citalopram, Escitalopram, Hydroxyzin, Domperidon and Piperaquin.

Caution when used

In cases of renal failure, sulpiride dose should be reduced and increased monitoring. If the renal failure is severe, it is recommended to treat each interrupt batch.

Need to strengthen monitoring of the following objects:

People with epilepsy: capable of lowering the threshold of seizures.

Elderly: prone to hypotension, sleepy and susceptible to extras.

Drinking alcohol or taking alcohol -containing drugs for increasing drowsiness.

High fever for unknown reasons, need to stop the drug to eliminate malignant neuroleptic syndrome.

People with mild mania, low -dose sulpiride can cause severe symptoms.

The ability to drive and operate machinery

Note when using the drug should not drink alcohol and alcoholic drinks because it will increase drowsiness when driving and operating machinery.

Pregnancy

Monitoring pregnant mothers who have not seen any special malformations due to sulpiride. Although there are no cases described in infants, but in theory, if continued to be used at the end of pregnancy, especially the use of sulpiride rubber can cause: fast heart, stimulation, abdominal distention, slow manipulation, muscle tone, tremor, sleep. Therefore, sulpiride can be used at any stage during pregnancy. Babies must be monitored to detect the above symptoms.

Lactation period

Sulpiride is distributed into breast milk in relatively large amounts and can cause unwanted reactions for breastfed babies. Therefore, women who are breastfeeding should not be used or stop breastfeeding if the drug is stopped.

Drug interactions

Parkinson -non -resistant dopamine owner (Carbergolin, Quinagolid) contraindicated in combination with sulpiride because of mutual antagonism.

Parkinson -resistant dopamine owner: Amantadin, Apomorphin, Bromocriptin, Entacapon, Lisurid, Pergolid, Piribedil, Pramipexol, Ropinirol, Selegilin: Mutual antagonism between dopamine and neuron. Dopamine drugs can cause or worsen mental disorders. In case of necessity to treat neuroleptics for people with Parkinson's disease being treated with dopamine, dopamine dose must gradually reduce dopamine until it stops completely (if this drug is stopped suddenly, there is a risk of malignant syndrome caused by neurolithic drugs).

Sedative: Morphin's derivatives (analgesic, anti -cough, replacement), Sedative, barbiturat, benzodiazopin, anxiety antidote in addition to benzodiazopin such as Meprobamat, sleeping drugs, anti -sedative drugs (Amitriptylin, Doxepin, Mianserin, Mirtazapin, Trimipramin) Sleeping, central blood pressure medicine, Baclofen, thalidomid when combined to increase the effect of inhibiting the central nervous system and reduce alertness and lower blood pressure.

The drug is capable of causing peaks mainly anti -arrhythmic drugs type 1A (quinin, hydroquinidin, disopyramid) and III (Amiodaron, Sotalol, Dofetilid, Ibutilid) and other drugs such as Bupridil, Cisaprid, Diphenamil, Erythromycin injected intravenous, Mizolastin, Vincamin Moxifloxacin, Spiramycin intravenously: There is a risk of increased arrhythmia, especially twisted.

Other neuroleptics that can cause torsion: Amisulprid, Chlorpromazin, Cyamemazin, Droperidol, Haloperidol, Levomepromazin, Pimozid, Pipotiazin, ServinDol, Tiaprid, Veraliprid: Increased risk of ventricular arrhythmia, special twisted.

Sucraflate or antacids containing aluminum or Magnesi Hydroxyd reduces sulpiride absorption. Therefore, sulpiride should be used after taking antacids for about 2 hours to avoid interaction.

Lithi: Increases the likelihood of causing extravagance disorders of sulpiride may be due to lithium that increases the ability to attach sulpiride to the dopaminergic d2 receptor in the brain.

Levodopa: Antagonism competes with sulpiride and sedative drugs, so contraindicated coordination Sulpiride with Levodopa. The lowest dose can be used with the two drugs for people with Parkinson's disease.

Alcohol: Increases the sleeping effect of the drug, so avoid drinking alcohol and alcoholic beverages while using sulpiride. Loss of consciousness when driving, operating machinery.

Beta blockers in heart failure (Bisoprolol, Carvedilol, Metoprolol, Nebivolol): Increased risk of ventricular arrhythmia, especially torsion. Clinical monitoring, electrocardiogram.

Medicines that reduce blood potassium: Diuretics hypoache, irritable laxatives, glucocorticoids,
tetracosactid, amphoticin intravenous injection: increased risk of ventricular arrhythmia, especially twisted. It is necessary to treat hypokalemia before using sulpiride and clinical monitoring, electrocardiograms and electrolytes.

Storage

Store at temperatures below 30ºC.

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