Dolo-Neurobion Merck medicine reduces joint pain, rheumatism (5 blisters x 10 tablets)

thiamin (vitamin B1)

Thiamin Pyrophosphate is an effective form of vitamin B1 and acts as a coenzyme for some enzymes (eg pyruvat dehydrogenase and transketolase). Therefore, vitamin B1 is mainly involved in carbohydrate metabolism; However, vitamin B1 also participates in the synthesis of lipids and amino acids.

Neurons are provided with energy through oxidation thanks to the enzyme and carboxyi reduction process of glucose, so the supply of adequate vitamin B1 is very important. Thiamin also participated in nerve impulse transmission. Moreover, the results obtained in experiments show that Thiamin has analgesic effect.

Other possible mechanisms of pain relief and nerve pain of Thiamin include the ability to interact with painful mediators at pain receptors, regeneration of damaged nerve fibers, stabilization of electrical irritation of nerves and improvement of axon sauce.

Activation of guanosin monophosphate depends on the path of the signal transmission of Kinase G (CGMP-PKG) may be associated with the ability to inhibit the pain of increased pain caused by the temperature of vitamin B1 (and possibly vitamin B12) caused by pressing the spinal lymph node.

pyridoxin (vitamin B6)

pyridoxal phosphate, the biological activity of pyridoxin, is the decisive coenzym in the metabolism of amino acids. It is involved in the formation of physiological amines (for example, serotonin, histamine, adrenalin) through carboxyl reducing processes as well as in the process of assimilation and catabolism through transaminization.

pyridoxal phosphate plays an essential role in the nervous system, especially in the transformation of neurotransmitters controlled by enzymes. As a catalyst in the first steps of Sphingosin biosynthesis, pyridoxal phosphate also plays the main role in the metabolism of sphingolipids. Sphingolipid is an essential ingredient of myelin bag of neuron cells. Animal experimental models have shown that vitamin B6 has analgesic effect.

pyridoxin is known as an essential cofactor in the production of neurotransmitters. Pyridoxin is involved in Tryptophan metabolism, resulting in serotonin synthesis. For this reason, it has been considered a medication to support treatment in a series of unusual neurotransmitter or suspected neuromuscular substances such as epilepsy, Parkinson's disease, depression, chronic pain, headache, adults and children and peripheral neuropathy.

cobalamin (vitamin B12)

Vitamin B12 exists in active forms (5-damyadenosyl cobalamin and methyl cobalamin) involved in the catalytic hydrogen displacement with enzyme and molecular spinach of methyl groups. Vitamin B12 also participates in methionine synthesis (closely combined with nucleic acid synthesis) and in lipid metabolism, through converting propionic acid into sucinic acid.

Vitamin B12 is involved in the basic methylation of myelin protein, a component of the myelin bag of the nervous system. Methylation increases the lipid characteristics of basic protein myelin, which is beneficial for the increase in the combination of myelin bags.

Vitamin B12 acts on pain as well as on pain.

diclofenac

diclofenac inhibits cyclooxygenase (COX) and lipoxygenase (LOX) - The enzymes convert arachidonic acid into prostaglandin and leukotrien, in the corresponding sense. Inhibiting these enzymes leads to diclofenac analgesic, anti -inflammatory and antipyretic effects. DiClofenac inhibits both COX-1 and COX-2, and tends to inhibit the selective COX-2. Diclofenac is significantly stronger than Indomethacin, Naproxen and other anti -inflammatory drugs.

In addition to the peripheral effect, Diclofenac and other nonsteroidal anti -inflammatory drugs may have an antagonistic effect on the central nervous system, the effect on the release of prostaglandin and/or through the nervous system using catecholamine and serotonin as well as neurotransmitters.

Combining vitamins B1, B6, B12 and Diclofenac

Vitamins B1, B6 and B12 are special for the metabolism of the nervous system, and their biochemical force is justified for the use of these vitamins. Animal studies have shown a combination of these B vitamins to promote the regeneration of damaged nerve fibers, eventually leading to enhancement of functional restoration and neurotransmitter.

In some pain models in rats, vitamins B1, B6 and B12 have shown the effect of antagonistic receptor, the combination shows higher efficiency than the effectiveness of each separate vitamin.

The combination of B vitamins and Diclofenac has been used in 1962 to treat painful diseases that combine perception and neurological pain (mixed pain), because of the coherent effect of this combination has been acknowledged and the treatment of pain with an nonsteroidal anti -inflammatory drug (NSAID) in combination with the treatment of available neurological lesions with B vitamins with effective B vitamins.

In the meantime, a number of control and random clinical studies have proven the superiority of the combination of vitamins B with diclofenac compared to Diclofenac monomers in the treatment of pain and show the significant syllable effects of vitamins B1, B6, and B12 for Diclofenac pain relief effects on humans.

Dynamic pharmacokinetics

It is not thought that the use of combinations of vitamins B1, B6 and B12 has an adverse effect on the pharmacokinetics of each individual vitamin.

thiamin (vitamin B1)

Using oral vitamin B1 is based on dual -dose transport mechanisms, which is the active absorption at a concentration of up to 2 µmol and passive diffusion when the concentration exceeds 2 µmol. There is almost no absorption in the stomach and in the distance of the small intestine.

Thiamin is formed by a lice bacteria in the colon, which is not absorbed. Thiamin's absorption occurs after phosphorylation in epithelial cells; A transport mechanism is thought to be related to the transition.

After absorbing by the intestinal mucosa, Thiamin is transported to the liver through the circulation. In the liver, Thiamin is phosphoryl turned into Thiamin Pyrophosphate (TPP) and Thiamin Triphosphate (TTP) thanks to Thiamin Kinase.

Thiamin is excreted with 1 hour half -life in the beta phase. The main excretion products are: Thiamin carboxylic acid, pyramin, thiamin and some unknown metabolites (excreted through the kidneys). The more Thiamin consumes, the higher the amount of Thiamin excreted in the form of the kidneys higher within 4-6 hours.

pyridoxin (vitamin B6)

Vitamin B6 (pyridoxin, pyridoxal and pyridoxamin) are quickly absorbed, mainly in the above digestive tract and transported to organs and tissues. Vitamins associated with albumin, about 80% pyridoxal phosphate associated with protein.

Vitamin B6 goes into cerebrospinal fluid, excreted into breast milk and penetrates the placenta. The main excretion product is 4 pyridoxic acid; The amount of this product is more or less depending on the dose of vitamin B6 used.

cyanocobalamin (vitamin B12)

The absorption of vitamin B12 from the gastrointestinal tract occurs in 2 mechanisms:

about 90% of cobalamine in plasma is associated with protein (transcobalamin). Most vitamin B12 does not circulate in plasma will be stored in the liver.

Vitamin B12 is mainly excreted through bile and is mostly reabsorbed through the intestinal circulation. If the body's reserve ability is exceeded due to high doses and, especially due to the use of the injection, the part that cannot be retained will be excreted in the urine.

diclofenac

Diclofenac is absorbed quickly and completely in the duodenum, reaching a significant plasma concentration after 30 minutes and a maximum plasma concentration within 2 or 3 hours. When used with food, Diclofenac is absorbed more slowly but the absorption level is not changed.

The drug is associated with plasma proteins (99.7%), mainly with albumin, and the half-life in plasma is 1-2 hours. Diclofenac is widely distributed in the body, with the highest concentration found in the liver and kidney.

The drug is metabolized in the liver by an isenzyme cytochrom P450 of the CYP2C family to 4 hydroxydiclofenac is the main metabolite and into other types of hydroxy. After the process of glucuronid and sulfate, metabolites are excreted in urine (65%) and bile (35%). Diclofenac repeated dose does not cause accumulation in healthy adults. The sale time is 1.2 - 2.0 hours.

Digestive: Exacection of ulcerative colitis or Crohn's disease, gingivitis and mouth, esophageal damage, tongue inflammation, constipation.