Domperidon 10mg Stada drugs treat symptoms of vomiting, nausea (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Domperidone

Ingredient

Composition information	Content
Domperidone	10mg

Uses

Indications

Domperidon drugs are indicated to treat symptoms of vomiting and nausea.

Pharmacokological

domperidon is dopamine resistant with anti -vomiting properties. In people using domperidon, especially adults, unwanted use as a very rare surgeon syndrome, but domperidon promotes prolactin secretion in the pituitary gland.

Anti -vomiting effects may be due to peripheral coordination (gastric activity) and dopamine receptor resistance in the CTZ chemical sensor area outside the brain blood barrier in the postrema area. Human studies show that the use of oral domeridon increases the pressure of the lower esophageal pressure, improves the permanent peristalsis and increases the empty process of the stomach. The drug does not affect the excretion of the stomach.

pharmacokinetics

Despite the rapid absorption, bioavailability of Domperidon's body only reaches about 15% in hungry people who drink single dose, and increase when using domperidon after meals. Low bioavailability due to drugs is metabolized through the liver for the first time and metabolism in the intestine.

more than 90% of domperidon is connected to plasma proteins and has a final waste time of 7.5 hours. Fast metabolism and many liver. The main metabolic path is reducing the Alkyl root at N's position thanks to the isenzyme CYP3A4 of Cytochrom P450 and the aromatic hydroxylation hydroxyl thanks to CYP3A4, CYP1A2 and CYP2E1.

About 30% of oral doses are excreted in urine within 24 hours, most of them in the form of metabolites; The rest is eliminated through feces after a few days and about 10% in intact form. Medicines are difficult to pass the brain barrier.

Small amount of domeridon is distributed into breast milk, the concentration reaches 10-50% in the mother's serum.

Before taking Domperidon 10mg Stada drugs treat symptoms of vomiting, nausea (10 blisters x 10 tablets)

How to use

Take oral use. Should drink domperidon stada 10mg before meals.

If taken after meals, the drug may be slowly absorbed.

Dosage

Adults and minors (aged 12 and older and weighing 35kg or more): Can be used up to 10mg x 3 times/day, a maximum dose of 30mg/day.

Patients with liver failure: Domperidon Stada 10mg Contraindicated to patients with medium and severe liver failure. No need to adjust the dose for patients with mild liver failure.

Patients with renal impairment: Due to the prolonged semi -discharged time of the domeridon in patients with severe renal impairment, if used repeated, the number of times using Domperidon Stada 10mg should be reduced to 1-2 times/day and adjust the dose depending on the level of renal failure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

Symptoms of overdose include chicken sleep, loss of orientation and foreign reactions, especially in children.

Handling

There is no specific antidote for domperidon, but in case of overdose, gastric lavage as well as use activated carbon may be useful. Strict medical monitoring and indications for supportive treatment.

anti -cholinergic drugs, Parkinson's treatments may be helpful in controlling foreign reactions. Should monitor the electrocardiogram because it is likely to extend QT.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using domperidon, you may experience unwanted effects (ADR).

Rare:

Domperidon is difficult to pass the brain blood barrier and is less likely to cause central nervous effects such as a foreign reaction or drowsiness compared to Metoclopramid. Foreign and drowsiness disorders occur in very low and often due to the permeability disorders of the brain barrier (premature babies, meningeal lesions) or overdose.

Cardiovascular disorders: ventricular arrhythmia, extension of QT, twisted, sudden death due to cardiovascular.

Harmful reaction report:

The reaction report is harmful after the drug is licensed to circulate very important to continue monitoring the benefits/risks of the drug. Health workers need to report all the harmful reactions to the National Center or regional center on drug information and monitor the harmful reactions of the drug.

Instructions on how to handle ADR:

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

contraindicated domperidon drug in the following cases:

Hypersensitivity to any ingredients of the drug.

Panisons with pituitary tumors cause prolactin secretion (prolactinoma).

Cases of stimulating stomach peristalsis can be dangerous for example, patients with gastrointestinal bleeding, mechanical bowel obstruction or puncture of the digestive tract.

Patients with average and severe liver failure.

Patients with prolonged heart impulse transmission time, especially QT interval, patients with clear electrolytes or patients with cardiovascular disease such as congestive heart failure.

Simultaneous use of the drugs extending the QT.

Concentric use of CYP3A4 inhibitors (regardless of the effect of extension of QT).

Be cautious when used

Renal failure: Domperidon's waste time is prolonged in patients with severe renal impairment. In the case of repeated use, the frequency of using domperidon should be reduced to 1-2 times/day depending on the degree of renal failure. Can adjust the dose if needed.

Cardiovascular:

domperidon extends the QT distance on the electrocardiogram. In the process of post -commerce monitoring, there are very few reports on the QT and vertical torsion related to the use of domperidon. These reports have risk factors such as electrolyte disorders or simultaneous medications.

Epidemic studies show that domeridon may increase the risk of severe ventricular arrhythmia or sudden cardiovascular disease. This risk is higher for patients over 60 years old, patients taking daily doses greater than 30mg and patients taking concurrently the drug extends the QT or CYP3A4 inhibitors.

Use domperidon with the lowest doses effectively in adults and children.

Contraindicated for patients with prolonged heart impulse transmission time, especially QT interval, patients with clear electrolytes (hypotension, hyperkalemia, hypoglycemia), blood rhythms or patients with cardiovascular disease such as serious blood failure due to the risk of ventricular disorders. Electrolyte disorders (hypotension, hyperkalemia, hypoglycemia) or slow heart rate have been known as a factor that increases the risk of arrhythmia.

Need to stop treatment with domperidon and exchange with health workers if there are any symptoms or signs related to arrhythmia.

Advise patients to quickly report symptoms on the heart.

Domperidon STADA 10mg contains lactose. This drug should not be used for patients with rare genetic galactose intolerance, Lapp Lactase or Glucose - Galactose.

The ability to drive and operate machinery

When using domperidon may occur from the non -tower and drowsiness reaction at a very low rate. If these unwanted effects, patients should not drive or operate machinery.

Pregnancy

unknown ability of drugs in humans. Therefore, domeridon should only be used during pregnancy when proving treatment benefits.

Breastfeeding period

domperidon excreted through breast milk and breastfed babies receive less than 0.1% dose according to the mother's weight. Unwanted effects, especially the effect on the heart can still occur after breastfed babies. The benefits of breastfeeding and the benefits of mothers treat to decide to stop breastfeeding or stop/avoid domeridon treatment. Caution should be careful in case of risk factors that extend the QT range in breastfeeding.

Drug interaction

Increased risk of extending the QT distance due to pharmacokinetic or pharmacokinetic interaction.

Contraindicated with the following drugs:

The drug extends the QT range:

IA's anti -arrhyths (for example: disopyramid, hydroquinidin, quinidine).

Anti -arrhythmia group III (for example: Amiodaron, dofetilide, droneedaron, ibutilid, sotalol).

Some anti -psychotic drugs (for example: Haloperidol, Pimozid, Servindol).

Some antidepressants (e.g. citalopram, Escitalopram).

Some antibiotics (for example: erythromycin, levofloxacin, moxifloxacin, spiramycin).

Some antifungal drugs (for example, pentamidin).

Some medications for malaria treatment (especially halofantrin, lumefantrine).

Some gastric - intestinal drugs (for example: Cisaprid, Dolasetron, Prucaloprid).

Some antihistamine drugs (for example: Mequitazin, Mizolastin).

Some cancer medications (for example: Tamoxifen, Vandetanib, Vincamin).

Some other drugs (for example: Bepridil, Diphemanil, Methadon).

Strong CYP3A4 inhibitors (regardless of the effect of extending QT), for example:

Protease inhibitors.

Azol body antifungal drugs.

Some macrolid drugs (erythromycin, clarithromycin and telithromycin).

Do not recommend using the following drugs:

Average CYP3A4 inhibitors, for example: diltiazem, verapamil and some macrolid drug groups.

Use cautiously when used simultaneously with the following drugs:

Heart rate slow, medications that reduce potassium and some macrolid drugs after contributing to extending the QT interval: Azithromycin and Roxithromycin.

The list of substances above are representative and incomplete drugs.

Storage

In closed packaging, dry place. The temperature does not exceed 30 ° C.

Other drugs

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