Donaton 20 Southeast Treatment Treatment of penis erection dysfunction (2 blisters x 2 tablets)

Dosage form Box of 2 blisters x 2 tablets
Specifications Tadalafil
Ingredient Impotence, erectile dysfunction, physiological weakness

Ingredient

Composition information	Content
Tadalafil	20mg

Uses

indications

Donaton 20 drug is indicated in case of penis erection dysfunction, loss of ability to achieve and maintain sufficient erection to intercourse.

Pharmacokology

Tadalafil is a phosphodiesterase type 5 inhibitor (PDE5) which is responsible for degeneration of CGMP in the Hang.

During sexual stimulation will cause nitric oxyd (NO) release from endothelial cells, stimulating the synthesis of guanosin monophosphate (CGMP) in plain muscle cells, CGMP causes smooth muscle dilatation and increases blood flow to the caves causing penis erection. The increase in CGMP will stabilize the function. When there are no stimuli from the outside, the drug does not cause any sexual effects.

pharmacokinetics

Tadalafil absorbed well through oral, peak plasma concentration achieved after about 30 minutes to 6 hours (on average about 2 hours), food does not affect the absorption of the drug.

Tadalafil is well distributed into the tissue, about 94% of Tadalafil is linked to plasma proteins, no more than 0.0005% of the dose is present in the semen of a healthy volunteer. The area under the curve (AUC) of Tadalafil increases proportional to the dose. Plasma concentrations in a stable state are achieved after 5 days (1 time/day), and AUC is about 1.6 times larger than using single dose. The half -life is about 17.5 hours in healthy people.

Metabolic mainly in the liver by Cytochrome P450 3A4 (CYP3A4) into non -active substances, methylcatechol and methylcatechololololololololololers. Elimination mainly in feces (61%), through urine (36%).

Before taking Donaton 20 Southeast Treatment Treatment of penis erection dysfunction (2 blisters x 2 tablets)

How to use

Donaton 20 should be used under the guidance of a doctor, oral medication.

Dosage

Use at the prescribed dose of a doctor or the usual dose.

Donaton 20 dose for men aged 18 and older: Tadalafil's usual recommendations are 10mg/time/day, drink at half an hour to 12 hours before intercourse (inside or outside meals). Dosage can increase to 20mg/time/day or decrease to 5mg/time/day depending on the response of each person.

Dosage Donaton 20 for people with renal failure: It is not necessary to reduce the dose in people with mild kidney failure.

Donaton 20 dose for people with liver failure: For mild to moderate liver failure people, dose not exceeding 10mg/time/day. Contraindicated with severe liver failure.

Donaton 20 dose for those who are taking CYP3A4 inhibitors ( ketoconazol , ritonavir ...) Maximum dose of 10mg/time/72 hours.

No need to reduce the dose in people over 65 years old.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

The main treatment is hemolysis to eliminate the body from the body.

What to do when forgetting a dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using the drug, you may experience unwanted effects (ADR).

Common side effects

Headache, indigestion, back pain, muscle pain, stuffy nose, pain in the limb.

Cardiovascular system: angina, chest pain, hypotension or hypertension, posture hypotension, nervousness, fast heartbeat. Perseptic. The nearest for timely management.

Warnings

Before using Donaton you need to read the user manual carefully and refer to the information below.

contraindicated

Donaton drugs contraindicated in the following cases:

Contraindicated for women, children under 18 years old.

Hypersensitivity to the ingredients of the drug.

Patients are taking nitrate derivatives, because Tadalafil has a synergistic effect with the hypotension effect of nitrate derivatives.

Patients taking alpha-blocker hypotension (Doxazosin, tamsulosin ...).

Cases of severe liver failure, low blood pressure, stroke, myocardial infarction.

For patients who have been recommended not to have sex.

Precautions when using

before treatment, must know the history of the disease and examine the patient specifically to specify the erectile dysplasia and potential roots. The patient's cardiovascular condition must also consider because of the risk of cardiovascular in combination with sexual activity.

Tadalafil has a vasodilation effect, which leads to slight decline of blood pressure and thus has the effect of hypotension with nitrates.

Tadalafil is a drug metabolized in the liver by CYP3A4, so if used with other CYP3A4 inhibitors (ketoconazole, ritonavir, erythromycin, otraconazole ...) will increase the tadalafil content in plasma and thus increase the risk of lowering blood pressure. Therefore, if used simultaneously with the above drugs, Tadalafil must not use more than 10mg/time/72 hours.

The safety and effectiveness of Tadalafil combinations with other erectile dysfunction treatments have not been studied, so this combination should not be used. Tadalafil does not work on bleeding time when used alone or used with aspirin.

Tadalafil has not been used in patients with bleeding disorders or digestive ulcers, so be careful when indicated after careful consideration.

The ability to cause prolonged erection can occur more than 4 hours), so when this phenomenon, whether pain or not must go to the medical center for treatment.

Safety for medication for the following patient groups has not been evaluated, so it should not be used: heart failure, angina, high blood pressure (> 170/100mmHg), or low blood pressure ( The use of Tadalafil can lead to temporary vision loss or loss of vision.

The ability to drive and operate machinery

No report.

Pregnancy and lactation

Tadalafil does not specify for pregnant and lactating women.

Tadalafil and its metabolites can overcome the placenta in the rat, and are present in the milk with a concentration of 2-4 times larger than plasma concentrations. It is still unknown whether Tadalafil and its metabolites whether or not to be eliminated in human milk, so it is not only for nursing women.

There is no evidence of teratogenicity, toxicity on the embryo, toxicity in the fetus in rats when using a dose of 1000mg/kg/day during the organization of the organ. Using Tadalafil in pregnant women has not been fully studied.

Drug interaction

Tadalafil is a drug metabolized in the liver by CYP3A4, so if used with other CYP3A4 inhibitors (ketoconazol, ritonavir, erythromycin, otraconazole ...) will increase Tadalafil content in plasma and thereby increasing risk pressure.

Used with CYP3A4 induction drugs (Rifampin, Carbamazepin ...) reduces the tadalafil content in plasma, so the effect will decrease.

Antacid (magnesihydroxy, aluminum hydroxyd) reduces the absorption of Tadalafil.

Tadalafil increases the hypotension effect of nitrate derivatives, so contraindicated use simultaneously with nitrate derivatives.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

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