Doniwell Kyung Dong medicine treatment of schizophrenia (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Levosulpiride
Ingredient Schizophrenia, digestive disorders

Ingredient

Composition information	Content
Levosulpiride	25mg

Uses

Indications

Doniwell drugs are indicated in the following cases:

levosulpiride is the main treatment is schizophrenia. Also indicated support for treatment in some cases of digestive disorders related to the central nervous system such as:

vomiting, nausea. Dopaminergic both central and peripheral. Levosulpiride is indicated as schizophrenic treatment, in addition to low doses (25mg x 3 times/day). Levosulpiride has the effect of supporting treatment in some cases of gastrointestinal disorders related to the central nervous system (levosulpiride that inhibits the dopaminergic system, has the ability to promote intestinal motility, increase the time to empty the stomach, and reduce discomfort due to stomach tension).

pharmacokinetics

Used by oral, levosulpiride is absorbed for 4-5 hours, the peak concentration of levosulpiride in plasma reaches 3 hours after oral the dose of 50mg is 0.25mg/l.

The bioavailability of oral form is from 25 to 35%, there may be significant differences between one person and others, the concentrations of levosulpiride in plasma are linearly related to the dose.

Levosulpiride is rapidly diffusing to tissues, especially to the liver and kidneys, the diffusion to the brain poorly, mainly to the pituitary gland.

The ratio attached to the plasma Proteine is less than 40%, the distribution coefficient to red blood cells and plasma is 1. The excretion of breast milk is estimated to be 1/1000 of the daily dose.

levosulpiride is excreted mainly through the kidneys, thanks to the filtration process in the glomerular. The renal clearance is usually close to the total clearance. With clinical records, Levosulpiride is very little metabolized in humans, 92% of the levosulpiride dose is found in urine in constant form.

Before taking Doniwell Kyung Dong medicine treatment of schizophrenia (10 blisters x 10 tablets)

How to use

Tablets, oral tablets. Take the tablet with a glass of water.

Dosage

Adults and children over 12 years old

1 capsule, 3 times/day, used before meals.

Children under 12 years old

Depending on the doctor's instructions.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? In some cases: The tremor syndrome is very serious, coma.

Handling

Stop drugs, treat symptoms that have occurred.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Doniwell, you may experience unwanted effects (ADR).

may have a sense of thirst, rash, vomiting, diarrhea, constipation, hypertension. The feeling of burning hot, disturbing itself, insomnia, drowsiness, dizziness, unsteady walking, helpless.

Occasionally: loss of menstruation in women, big breasts in men (stop drugs).

Rare: trembling, tongue, anxiety, rash, edema (Stop drug).

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Doniwell drugs contraindicated in the following cases:

Hypersensitivity to levosulpiride or any ingredients of the drug.

Precautions when used

drivers or machinery.

breastfeeding women.

Because the drug is mainly eliminated through the kidneys, it is necessary to be careful to reduce the dose and should not be treated continuously in patients with severe renal failure.

Should strengthen monitoring in patients with epilepsy because drugs can reduce the threshold of epilepsy.

can be used but need to be cautious in Parkinson's disease.

The ability to drive and operate machinery

Drowsy, falling asleep, often recorded in the beginning of the therapy with levosulpiride, no drug when driving or operating machinery.

Pregnancy

Not used for pregnant women or suspected pregnancy because the drug can cause side effects for the fetus.

Breastfeeding period

The excretion of breast milk is estimated to be 1/1000 of the daily dose. Although Levosulpiride increases milk secretion and has applied treatment for this purpose, it can cause side effects in newborns, so it is not advisable to use medication at the period of breastfeeding or not breastfeeding during treatment.

Drug interaction

Interaction

Do not coordinate with anticholinergic drugs, sleeping pills, anesthesia and painkillers.

Be cautious when used with digitalis, other benzamide, mental medicine.

abstain from alcohol, avoid drinking alcohol and drinks or drinks containing alcohol.

Contraindications for coordination

Levodopa: There is a competitive antagonist between Levodopa and Levosulpiride.

Note when coordinating

Medicines for high blood pressure treatment: increase the effect of hypotension and can cause posture lowering (due to the co -effect).

Central neurological inhibitors: Antidepressants have sedative effects, antihistamine H1 drugs have sedative effects, barbiturates, sedative drugs, clonidine and drugs with them, sleeping pills, methadone: Increasing central neurological inhibition, can cause bad consequences, especially in those who have to drive or control machines.

The use of levosulpiride with mucosal bandages, anti -gastrointestinal tanks containing magnesium hydroxid, aluminum hydroxid reduces the bioavailability of levosulpiride, so should not use levosulpiride together or after the above drugs.

Storage

Keep the drug in a cool dry place, temperatures below 30 ° C. Avoid light.

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