Dopagan 500mg Domesco medicine relieves and reduces fever (20 blisters x 10 tablets)

Dosage form Box of 20 blisters x 10 tablets
Specifications Paracetamol

Ingredient

Composition information	Content
Paracetamol	500mg

Uses

indications

Dopagan 500mg is an OTC drug widely used in the treatment of symptoms of pain and mild to medium fever and fever.

Treatment of pain:

Paracetamol is used temporarily in the treatment of mild and medium pain. The most effective drug is to reduce low intensity pain from non -internal organs.

paracetamol does not treat rheumatism.

paracetamol is a salicylate replacement (preferred in patients with contraindications or unsafe salicylate) for mild or fever -reducing pain.

Treatment of fever:

paracetamol is often used to reduce body temperature in fever, when fever may be harmful or when antipyretic, the patient will be more comfortable.

However, antipyretic therapy is generally not specific, does not affect the process of the basic disease, and can cover the disease condition of the patient.

Pharmacy

Paracetamol (acetaminophen or N-acetyl-P-Aminophenol) is an active metabolic substance of phenacetin, an effective analgesic-antipyretic. Paracetamol reduces body temperature in fever, but rarely reduces the body temperature in normal people.

Dopagan 500mg drug acts on the hypothalamus, causing cooling, increasing heat due to vasodilation and increased peripheral blood flow.

Paracetamol, with treatment dose, less impact on the cardiovascular and respiratory system, does not change acid -base balance, does not cause irritation, scratches or stomach bleeding as when using salicylate, because paracetamol does not work on the body cycloxygenase, only affect cycloxygenase/prostaglandin of the central nervous system. Paracetamol does not work on platelets or bleeding time.

When overdose of paracetamol, a metabolic substance is N-acetyl-benzoquinonimin that is toxic to the liver. Normal dose, paracetamol well tolerated. However, dopagan excess overdose 500mg (over 10g) causes liver damage to death.

pharmacokinetic

absorption

Paracetamol is absorbed quickly and almost completely through the gastrointestinal tract.

Peak concentration in plasma reaches 30 to 60 minutes after drinking with treatment dose.

Distribution

Paracetamol is distributed quickly and evenly in most body tissues. About 25% Paracetamol in the blood combined with plasma protein.

Elimination

Paracetamol plasma sale time is 1.25 - 3 hours, which can last for toxic doses or in patients with liver damage.

After the treatment dose, 90 to 100%of the urine can be found on the first day, mainly after the liver combination with glucuronic acid (about 60%), sulfuric acid (about 35%) or cysteine (about 3%); It also detects a small amount of hydroxyl metabolites - chemicals and reducing acetyl. Children are less likely to glucuro than drugs than adults.

paracetamol is n-hydroxylation by cytochrom P450 to create N-acetyl-Benzoquinonimin, an intermediate reaction. This metabolic substance normally reacts with sulfhydryl groups in glutathion and thus is dedicated. However, if taking high doses of paracetamol, this metabolic is formed in sufficient amount to exhaust the glutathion of the liver; In this situation, its reaction to the sulfhydryl group of liver protein increases, which can lead to liver necrosis.

Before taking Dopagan 500mg Domesco medicine relieves and reduces fever (20 blisters x 10 tablets)

How to use

oral medication. Take the tablet with a full glass of water.

Dosage

To reduce pain or reduce fever for adults and children over 11 years old: The common dose is 500 mg, every 4-6 hours when necessary, but not more than 4 g a day; The larger dose (eg 1g) may be helpful to relieve pain in some patients.

Do not use itself for self -relieving pain for more than 10 days in adults or more than 5 days in children, unless the physician is instructed, because of such a lot of pain and prolonged pain may be a sign of a pathological condition that needs to be diagnosed and treated by a physician.

Do not use for adults and children to treat high fever on their own (over 39.5 ° C), fever lasting for more than 3 days, or recurrent fever, unless it is instructed by a physician, because such a fever may be a sign of a serious illness that needs to be diagnosed quickly by a physician.

To minimize the risk of overdose: Do not give children more than 5 doses of paracetamol to reduce pain or reduce fever within 24 hours, unless the physician is instructed.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Paracetamol poisoning may be due to a single -dose or a large dose of Paracetamol (7.5 - 10g per day, for 1-2 days) or due to dopagan 500mg daily. Liver necrosis depends on the dose is the most serious toxic effect due to overdose and can be fatal.

Signs of overdose

Symptoms in the gastrointestinal tract: Nausea, vomiting and abdominal pain usually occur within 2-3 hours after taking the toxic dose of Dopagan 500mg.

methemoglobin-lead, leading to purple blue, mucous and nail is a sign of acute poisoning P-aminophenol; A small amount of sulfhemoglobin can also be produced.

Children tend to create methemoglobin easier than adults after taking paracetamol.

Symptoms of severe poisoning: When severe poisoning, initially stimulates the central nervous system, agitated and delirium. Next can be inhibiting the central nervous system; Stunned, lower body temperature; tired; Breathing fast, shallow; fast, weak, uneven circuit; Low blood pressure; circulatory.

Vascular collapse due to relative hypoxia and central inhibition effects, this effect only occurs in huge doses.

Shock may occur if a lot of vasodilation. The suffocating convulsions may occur.

often coma occurs before dying suddenly or after a few days of coma.

Liver lesions: The clinical signs of liver damage become significantly within 2 to 4 days after taking toxic dose.

Aminotransferase plasma increases (sometimes very high) and plasma bilirubin levels may also increase.

When the liver damage spreads, the long prothrombin time. It is possible that 10% of patients with untreated poisoning have serious liver damage; Among them 10% to 20% finally die from liver failure.

Acute renal failure also occurs in some patients. Liver biopsy detects central necrosis subtracting the area around the portal vein.

In cases of non -death, liver lesions recover after weeks or months.

How to overdose

Early diagnosis is important in the treatment of dopagan overdose 500 mg. When severe poisoning, active support treatment, gastric lavage in all cases, preferably within 4 hours after drinking.

The main detoxification is the use of sulfhydryl compounds, perhaps partly impacted by the addition of glutathion reserves in the liver.

n-acetylcysteine works when taken or intravenously. Must give the drug immediately if less than 36 hours after taking paracetamol.

Treatment with N-Acetylcystein is more effective when giving the drug for less than 10 hours after taking paracetamol. When drinking, dilute N - Acetylcystein solution with water or drink without alcohol to achieve a 5% solution and must be taken within an hour after mixing.

Give N-Acetylcystein with the first dose of 140mg/kg, then give 17 more doses, each dose of 70mg/kg each 4 hours apart.

Termination of treatment if the paracetamol test in plasma shows a low risk of liver toxicity.

The unwanted effect of N - AcetylCystein includes skin rash (including urticaria , no need to stop the drug), nausea, vomiting, diarrhea, and anaphylactic reaction.

without n-acetylcystein, methionine may be used. Also can use activated carbon and/or salt bleach, they have the ability to reduce the absorption of paracetamol.

What to do when forgetting a dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using the drug, you may experience unwanted effects (ADR):

occasionally occur skin rash and other reactions, usually Red Red Red Redes. But sometimes worse and may be accompanied by drugs and mucosal lesions. People who are sensitive to salicylate rarely hypersensitive to paracetamol and related drugs.

In a few individual cases, paracetamol has caused neutrophils, thrombocytopenia and all bloody hemoglobin.

Less:

Ban.

nausea, vomiting.

Hemorrhagic disorders (neutropenia, all bloody, leukopenia), anemia.

Kidney disease, kidney toxicity when abusing for a long time.

Rare:

Hypersensitivity reactions.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Contraindications in the following cases:

People with anemia many times, heart disease, lung, kidney or liver.

Patients with paracetamol and other ingredients of the drug.

People with a shortage of glucose-6-phosphate dehydrogenase.

Precautions when using

Doctors need to warn patients on signs of serious skin reactions such as:

Steven-Johnson syndrome (SJS).

Poisoned skin necrosis syndrome (Ten).

Lyell syndrome.

Agep all -body pustules syndrome (AGEP).

Symptoms encountered when taking the drug:

Paracetamol is relatively non -toxic to the dose of treatment. Sometimes there are skin reactions including itchy rash and urticaria; Other sensitive reactions include larynx edema, angioedema, and anaphylactic reactions that may rarely occur. Platelets, leukopenia, and all bloody hematuria have occurred with the use of p-aminophenol derivatives, especially when used for large doses. Neutral leukopenia and thrombocytopenic decrease occur when using paracetamol.

Rarely loss of granulocytes in patients using paracetamol.

In case the patient needs to be cautious:

People with phenylceton-urine (genetic shortage determine the condition of phenylalanin hydroxylase) and people who have to limit the amount of phenylalanin put into the body must be warned as some paracetamol preparations containing aspartam, which will metabolize in the stomach-intestinal citadel phenylalanin after drink.

Some forms of paracetamol drugs on the market containing sulfit may cause allergic reactions, including anaphylaxis and life -threatening or less serious hypersensitivity attacks in some hypersensitivity people. Do not know the general ratio of hypersensitivity to sulfit among the people in general, but it must be low: Such hypersensitivity seems to be more common in patients with asthma in people without asthma.

Must use paracetamol carefully in patients with anemia before, because purple blue may not manifest clearly, although there are dangerous high concentrations of methemoglobin in the blood.

Drinking plenty of alcohol can cause toxicity to the liver of paracetamol, should avoid or limit drinking alcohol.

The ability to drive and operate machinery

The drug has almost no effect on driving and operating machinery.

Pregnancy and lactation

Pregnant women: The safety of paracetamol has not been determined when pregnant is related to unwanted effects that may be available to pregnancy development. Therefore, only Dopagan 500mg should be used in pregnant people when needed.

Lactating women: Research in mothers using paracetamol after breastfeeding, do not see unwanted effects in breastfeeding.

Medicinal interaction

Long -doses of doses doses dopagan 500mg gently increases the anticoagulant effects of COMAARin and indoors. This effect seems less or not clinically important, so paracetamol is more popular than salicylate when it is necessary to relieve mild pain or reduce fever for patients who are using cooumarin or indandion.

Paracetamol has the potential to cause serious antipyretic in patients with simultaneously phenothiazine and cooling therapy.

Out of alcohol too much and long can increase the risk of paracetamol toxic to the liver.

Anti -convulsions (including Phenytoin, Barbiturat, Carbamazepin) that causes enzyme induction in the liver microsom, which can increase the toxicity of the liver toxicity of paracetamol due to increased drug metabolism into toxic substances to the liver.

Limit self -use of paracetamol while taking anti -convulsions or isoniazid because it can increase the toxic liver toxicity of paracetamol.

Probenecid may reduce paracetamol elimination and increase the half -life of plasma of paracetamol.

Isoniazid and tuberculosis drugs increase the toxicity of paracetamol for the liver.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

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