Dopharalgic 500mg dopharma drugs treat infections at a mild and medium level (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Cefprozil
Ingredient Tonsillitis, pharyngitis, pneumonia, respiratory infections, skin infections

Ingredient

Composition information	Content
Cefprozil	500mg

Uses

indications

Dopharalgic drug is indicated in the following cases:

Treatment of infections is mild and medium due to sensitive bacteria:

Upper respiratory infections:

Sore throat/tonsillitis: Due to Streptococcus Pyogenes. In the treatment and prophylaxis due to streptococcal infections, including low heart disease, the drug is often chosen as penicillin used intramuscularly. Cefprozil is generally effective in removing Streptococcus Pyogenes from the nose; However, there is currently no sufficient data to determine the effectiveness of Cefprozil in low heart disease. Lower respiratory bacteria:

Secondary and acute secondary pneumonia of chronic pneumonia (caused by streptococcus pneumoniae, Haemophilus influenzae (including secretions - lactamase) and Moraxella Catatrhalis (including secretions - lactamase)).

Skin infections and uncomplicated skin structure:

Due to staphylococcus aureus (including penicillinase strains) and streptococcus pyogenes.

Pharmacology

Pharmacological group: Cephalosporin antibiotics 2.

ATC code: J01DC10.

Cefprozil is a synthetic cephalosporin antibiotic, the second generation has the effect of killing bacteria that are developing and dividing by inhibiting synthesis of bacterial cells. Cefprozil has the effect of in vitro as well as in clinical for the following bacteria:

bacteria gram (+): staphylococcus aureus (including the strains - lactamase).

Note: Cefprozil does not work with staphylococci resistant methicillin.

streptococcus pneumoniae.

streptococcus pyogenes.

bacteria gram (-):

Haemophilus Influenzae (including the strains - lactamase).

Moraxella Catnrhalis (including strains - lactamase).

Dynamic pharmacokinetics

After taking Cefprozil, the drug is quickly absorbed in the digestive tract, about 95% of the absorbed dose. The peak concentration of the drug in plasma after taken dose of 250 mg, 500 mg or 19 is about 6.1; 10.5 and 18.3 mcg/ml achieved after about 1.5 hours of medication.

In children from 6 months - 12 years old, the peak concentration in plasma is achieved after 1-2 hours, the sale time is about 1.5 hours. The concentration of drugs in plasma after taken dose 7.5; 15 and 30 mg/kg equivalent to adults using the dose 250, 500 and 1000 mg at the same time.

On a healthy volunteer person using a single dose of 1g, adults over 65 years old with AUC higher than 35 - 60% and kidney clearance is 40% lower than young people aged 20 - 40 years old.

The average AUC in women is 15-20% higher than men. The degree of pharmacokinetics changes of Cefprozil related to age and gender is not enough to request the dose adjustment.

The ability to bind to the plasma protein of Cefprozil is about 36% and does not depend on the concentration of about 2 - 20 mcg/ml of plasma. There is no evidence of the accumulation of cefprozil in plasma in people with normal kidney function after taking multiple doses (up to 1000 mg every 8 hours in 10 days).

About 60% of the dosage dosage deduction in urine in the form of unchanged within 8 hours. The average selling time for the drug on healthy objects is 1.3 hours, which can last up to 5.2 hours on people with impaired renal function depending on the degree of renal failure. Hemorrhage is shortening the sale time of Cefprozil. In patients with impaired liver function, the sale time increases (about 2 hours). The degree of change is not much so there is no need to adjust the dose on this object.

Before taking Dopharalgic 500mg dopharma drugs treat infections at a mild and medium level (2 blisters x 10 tablets)

How to use

oral tablets. Take the tablet with a glass of water.

Dosage

Adults and children over 13 years old:

pharyngitis/tonsillitis: 500 mg per 24 hours, used for 10 days. Use for 10 days. Use for 10 days.

Children from 6 months - 12 years old:

Liem tonsillary pharyngitis: 7.5 mg/kg per hour, used for 10 days. In 10 days.

Patients with renal failure:

For patients with creatinine clearance

Cefprozil is partially eliminated by dialysis, so Cefprozil should be taken after dialysis.

Patients with liver failure:

No need to adjust the dose for patients with liver failure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms of overdose of cephalosporin antibiotics such as nausea, vomiting, epigastric pain, diarrhea, convulsions, ...

Management: Cefprozil is excreted mainly through the kidneys. In the case of severe overdose, especially in patients with damaged kidney function, dialysis will support the removal of Cefprozil from the body.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using the drug, there are common unwanted effects (ADR) such as:

Cefprozil's unwanted side effects are similar to other oral cephalosporins. Cefprozil is often tolerated in the controlled clinical trial. About 2% of patients stopped treatment with Cefprozil with unwanted effects.

Common (ADR ≥ 1/100):

Digestive: diarrhea, nausea, vomiting, abdominal pain. Dao.

Central nervous system: Increased excitement, headache, stress, insomnia, confusion, chicken sleep. These reactions are more reported in children in adults.

Allergic reactions: Anaphylaxis, angioedema, serum like Stevens - Johnson syndrome. The common unwanted use of cephalosporins:

Anemia, hemolytic anemia, hemorrhage, epidemic necrosis, poisoning kidney disease, prolonged prothrombin time, hypoglycemia, positive test combs, neutropenia, granulocytosis.

Instructions on how to handle ADR:

Before starting treatment with cefprozil, it is necessary to carefully investigate the patient's allergic history with cephalosporin, penicillin or other drugs.

If hypersensitivity occurs, the drug should be stopped and treated for patients (using epinephrin, oxygen breathing, antihistamine, corticosteroids).

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Dopharalgic drug contraindicated in the following cases:

People with a history of allergies to cefprozil and antibiotics of cephalosporin or with any ingredients of the drug.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Personal history or family allergic: urticaria, rash, bronchial asthma.

Patients with severe renal failure, elderly, exhaustion.

Cefprozil 500 mg contains lactose. Patients with rare genetics are galactose intolerance, Lapp lactase or glucose absorption disorders - Glactose should not use this drug.

Patients should be advised that antibacterial drugs include Cefprozil 500 mg should only be used to treat infections. These drugs do not treat viral infections. When using Cefprozil 500 mg is indicated to treat bacterial infections, patients should be notified that: Although it is commonly used for treatment, the drug should be used as directed. Unconstraints or failing to complete the treatment can reduce the effectiveness of immediate treatment and increase the ability to develop drug resistance and will not be treated with Cefprozil 500 mg or other antibiotics in the future.

The effect of the drug on driving and operating machinery

There is no evidence of the effect of the drug on the ability to drive and operate machinery.

Use drugs for women during pregnancy and lactation

pregnancy:

There is no data on drug use in pregnant women, should only use the drug if the benefits are superior to the risk.

breastfeeding period:

Small amount of Cefprozil (

Medicinal interaction

The impact of cefprozil on other drugs: simultaneously used with aminoglycoside increases the toxicity of the kidneys.

The impact of other drugs from Cefprozil: Antacid drugs do not affect Cefprozil's absorption.

Simultaneously used with Probenecid: 2 times the AUC of Cefprozil.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children, read the user manual carefully before use.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.