Dopiro D Southeastern medicine for osteoporosis, rickets (10 blisters x 10 tablets)

Calcium cans are essential for many biological processes:

Stimulates neurons, releases neurotransmitters, muscles, preserving membranes and coagulating. Calcium cans also help the secondary communication function for the activity of multiple hormones.

On the cardiovascular system:

Calcium cans are essential for stimulating and contracting myocardial as well as for electrical impulses on some areas of the heart muscle, especially through the atrial node.

On the muscular nervous system:

Calcium ion plays an important role in stimulation and muscle contraction

vitamin D3 (cholecalciferol)

There is a preventive activity or treatment of rickets by helping the body maintain the amount of phosphocalca available in the body to chemical bones, along with parathyroid hormones and calcitonin, vitamin D maintains normal plasma calcium and phosphorus concentrations in plasma by increasing the effectiveness of the absorption of minerals from diet, small intestine, and increasing calcium and phosphorus from bone into blood into the blood. Ergocalciferol and Cholecalciferol's activities may have a negative response effect on the formation of thyroid hormones (PTH).

Dynamic pharmacokinetics

calcium

absorption

calcium is absorbed mainly through the small intestine thanks to the active transportation and passive diffusion mechanism. About 1/3 of calcium is absorbed, although this ratio may vary depending on the diet and small intestine. Vitamin D helps increase calcium absorption.

Distribution and metabolism

99% of calcium in the body is concentrated in bones and teeth, the remaining 1% is distributed in intracellular and extracellular fluid. About 50% of calcium concentration in plasma in the form of ionization of physiological activity; About 5% form a complex with phosphate, citrate or other anion and the remaining 45% are linked to protein, mainly albumin.

Elimination

The amount of calcium ions is discharged from urine depends on glomerular filtration and reabsorption in the renal tubules, more than 98% of the amount of calcium ion filtered through the glomerular reabsorption into the bloodstream. A significant amount of calcium is deducted from milk during breastfeeding, a part of sweat and stool.

cholecalciferol (Vitamin D3)

absorption

cholecalciferol is well absorbed through the gastrointestinal tract, mainly from the small intestine.

Distribution and metabolism

cholecalciferol is hydroxylation in the liver forming 25 - hydroxycholeciferol. This substance continues to be hydroxylation in the kidneys to form a metabolism of 1.25 - dihydroxycholeciferol is active; This is a substance that increases calcium absorption. The non -metabolic part is stored in fat and muscle tissue.

Elimination

cholecalciferol and its metabolites are excluded mainly through bile and feces, only a small amount appears in the urine.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Caution when using

using too much calcium salts can lead to hypercalcemia.

It is necessary to notify the doctor about the history of the disease, especially in diseases: Sarcoidosis) or the parathyroidism (which can cause increased sensitivity to vitamin D), kidney failure, a history of kidney stones, heart disease, atherosclerosis, liver disease, intestinal disease (Crohn's disease, whipple's), gastricular shortage ...

Monitoring of calcium and urine concentration in patients with kidney failure, a history of kidney stones ... or are using vitamin D if long -term treatment in these patients.

Because the drug contains vitamin D, the use of more vitamin D needs medical monitoring to avoid overdose.

Not used simultaneously with other supplements containing calcium and vitamin D.

The ability to drive and operate machinery

The drug does not affect the ability to drive or operate machinery during treatment.

Pregnancy

For pregnant and lactating women, the daily dose must not exceed 1500 mg of calcium and 600 IU vitamin D3.

The period of breastfeeding

Because calcium and vitamin D3 can be secreted through breast milk, you must consult your doctor first to see if your baby is used for any other product containing vitamin D3.

Interactive drug

In case of using drug containing digitalis, the use of calcium in combination with vitamin A oral toxicity of digitalis (Risk of arrhythmia), need to be closely monitored and if necessary, regular monitoring of electrocardiograms and blood calcium.

In case of treatment combined with biphosphonate or Fluorid salt, it is recommended to spend a minimum period of 2 hours before using calcium (risk of reducing absorption in the stomach of biphosphonate and fluorid salt).

In case of use with thiazid diuretics will reduce the secretion of calcium in the urine, recommend that tighten blood calcium monitoring.

In the case of treatment with Tetracylines antibiotics (may reduce tetracycline absorption). The above drugs must be used for at least 2 hours or 4-6 hours after using d.

The case of using more vitamin D in high doses, weekly monitoring the amount of calcium in serum and urine is essential.

Glycoside cardiac (like digoxin): can cause additional side effects if you drink too much calcium.

estramustin (chemotherapy), thyroid hormones or iron, zinc or stronti -containing drugs because it can reduce the content of the body absorbed.

The above drugs must be used for at least 2 hours before or after using Dopiro Dorlistat (obesity medication), cholestyramine, laxative such as paraffin oil because it can reduce the vitamin D3 content that the body absorbs.

This drug can interact with foods containing oxalic acid (spinach, royal, red amaranth, cocoa, tea ...), phosphate (pork, ham, sausage, processed cheese, dessert cream, cola -containing drinks ...) or phytic acid (synthetic cereals, dried vegetables, oil seeds, chocolate ...). Therefore, it is necessary to use the drug away from the meal containing these foods.