Dopropy 1200mg Southeast medicine for dizziness (10 blisters x 10 tablets)

Used in the treatment of muscle vibration of the cortex.

Pharmacy

piracetam (derivative of the Amino-butyric gamma acid, GABA) is considered a substance that has a mental effect (improving the metabolism of neuron cells), although people do not know much about its specific effects as well as its mechanism of effect.

Even the definition of Hung Tri Nootropic is still vague. In general, the main effect of drugs is called Hung Tri (such as: Piracetam, Oxiracetam, Aniracetam, Etiracetam, Pramiracetam, Tenilsetam, Suloctidil, Tamitinol) is to improve learning and memory.

Many of these substances are considered to have a stronger effect on piracetam in terms of learning and memory. It is thought that in normal people and in people with impaired function, Piracetam works directly to the brain to increase the activity of the brain area (the brain area is involved in the mechanism of awareness, learning, memory, alertness and consciousness).

Piracetam acts on some neurotransmitters such as acetylcholin, noradrenalin, dopamin ... This can explain the positive effects of the drug on learning and improve the ability to perform memory tests.

The drug can change neurotransmitter and contribute to improving the metabolic environment so that the nerve cells work well. On experiments, Piracetam has a protective effect against metabolic disorders due to ischemia by increasing brain resistance to oxygen deficiency.

Piracetam increases the mobilization and use of glucose without depending on the supply of oxygen, facilitates the pentose path and maintains energy synthesis in the brain. Piracetam enhances the recovery rate after damage due to lack of oxygen by increasing the rotation of inorganic phosphate and reducing glucose and lactic acid accumulation.

Under normal conditions as well as when oxygen deficiency, Piracetam is found to increase the amount of ATP in the brain due to increased ADP conversion to ATP; This may be a mechanism to explain some useful effects of the drug. The impact on acetylcholine transmission (increasing the release of acetylcholin) may also contribute to the mechanism of action of the drug.

The drug also works to increase dopamine release and this may have a good effect on memory formation. The drug has no effect on sleep, sedation, resuscitation, analgesic, nervous or neuron and no effect of GABA.

Piracetam reduces the ability to converge platelet and in case of abnormal erythrocytes, the drug can cause red blood cells to restore deformation and ability to pass through capillaries. The drug has anti -vibration effect.

Piracetam used by oral is absorbed quickly and almost entirely in the digestive tract. Biology nearly 100%. Peak concentration in plasma (40 - 60 micrograms/ml) appears 30 minutes after taking a 2g dose. The peak concentration in cerebrospinal fluid is achieved after taking the drug 2 - 8 hours.

Absorption of drugs does not change when long -term treatment.

The distribution volume is about 0.6 liters/kg. Piracetam absorbed into all tissues and may be through the blood - brain, placenta barrier and even the membranes used in the kidney. The drug has high concentrations in the cerebral cortex, frontal lobe, top lobe and occipital lobes, cerebellum and base cores.

Half lifetime in plasma is 4-5 hours; Half life in cerebrospinal fluid is about 6 - 8 hours. Piracetam is not attached to plasma proteins and is excreted through the kidneys in the form of intact.

The kidney's piracetam clearance coefficient in normal people is 86 ml/min. 30 hours after drinking, more than 95% of the drug is discharged in urine. If there is a kidney failure, half a lifetime elimination increases: In patients with complete renal failure and not recovering, this time is 48 - 50 hours.

pharmacokinetic

absorption

Used by oral is absorbed quickly and almost entirely in the digestive tract. Birth nearly 100%. Absorption of drugs does not change during long -term treatment.

distribution

The distribution volume is about 0.6L/kg. Piracetam absorbed into all tissues and can pass through the bloody brain barrier, placenta and even the membranes used in the renal roses. Piracetam is not attached to plasma proteins.

Elimination

is excreted through the kidneys in the form of intact, the kidney's piracetam clearance coefficient in normal people is 86ml/min, 30 hours after drinking, more than 95% of the drug is waste in urine. In people with kidney failure, the selling time increases.

Uncommon, 1/1000