Dorabep 800mg Southeast medicine for dizziness (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Piracetam
Ingredient Ischemic anemia, muscle vibration, memory impairment, stroke, memory disorders, headache, dizziness, hemiplegia, nerve inflammation

Ingredient

Composition information	Content
Piracetam	800mg

Uses

indications

Dorabep 800 mg drug is indicated in the following cases:

Treatment of dizziness symptoms. - Aminobutyric, GABA) is considered to be a substance that has a mental effect (improving the metabolism of nerve cells), although people do not know much about its specific effects as well as its mechanism of action.

Piracetam affects some neurotransmitters such as acetylcholin, noradrenalin, dopamin ... This can explain the positive effect of the drug on learning and improve the ability to perform memory tests. The drug can change neurotransmitter and contribute to improving the metabolic environment so that the neurons work well.

Experimental, piracetam has a protective effect against metabolic disorders due to ischemia by increasing brain resistance to oxygen deficiency. Piracetam increases the mobilization and use of glucose without depending on the supply of oxygen, facilitates the pentose path and maintains energy synthesis in the brain.

Piracetam enhances the recovery rate after damage due to lack of oxygen by increasing the rotation of inorganic phosphate, reducing glucose and lactic acid accumulation. Under normal conditions as well as oxygen, piracetam increases the amount of ATP in the brain due to increased ADP conversion to ATP, this may be a mechanism to explain some of the useful effects of the drug.

In addition, the impact on the transmission of acetylcholin fluid (increasing the release of acetylcholin) can also contribute to the mechanism of action of the drug. The drug also has the effect of increasing the release of dopamine, which works well on the formation of memory. The drug has no effect on sleep, sedation, resuscitation, analgesic, nervous or neurological and no effect of GABA.

Piracetam reduces platelet aggregation and reduces blood viscosity at high doses. In case of abnormal erythrocytes, the drug can cause red blood cells to recover the ability to deform and pass through capillaries. The drug has anti -vibration effect.

Pharmacokinetics

absorption

After drinking, Piracetam is absorbed quickly and almost entirely in the digestive tract. Constant absorption when long -term treatment. Bioions reach nearly 100%. The peak concentration of plasma is achieved within 1.5 hours after drinking. The peak concentration in the cerebrospinal fluid is achieved after drinking 2 - 8 hours. Peak concentration in plasma reaches 40 - 60 μg/ml 30 minutes after taking a dose of 2 g.

Distribution

Piracetam is distributed into all tissues and can be through blood -brain barriers, placenta and even diaphragms used in the kidney. The drug has high concentrations in the cerebral cortex, frontal lobe, top lobe and occipital lobes, cerebellar and base nuclei. The distribution volume is about 0.7 liters/kg.

Metabolism

So far, there is no metabolite of Piracetam has been found.

Elimination

Selling time for plasma is about 5 hours. Piracetam is not attached to plasma proteins and is excreted through the kidneys in the form of intact. Piracetam clearance coefficient of the kidney in normal people is 86 ml/min. 30 hours after drinking, more than 95% of the drug is discharged in urine. If the renal failure is severe and does not recover, the excretion time increases to 48 - 50 hours.

Before taking Dorabep 800mg Southeast medicine for dizziness (10 blisters x 10 tablets)

How to use

oral medication, can be taken with food.

Dosage

Adults

Dizziness: Drink from 2.4 to 4.8 g/day, divided into 2-3 times/day.

Muscle vibration of the cerebral cortex: daily dose starts from 7.2 g; Then increase 4.8 g every 3-4 days, up to 24 g, divided into 2-3 times. Treatment with other anti -weak medications must be maintained at the same dose. Depending on the benefits, reduce the dose of other drugs if possible.

Elderly

Needs to adjust the dose in the elderly impaired renal function. If long -term treatment, monitor creatinine clearance to adjust the dose if needed.

Patients with renal failure

Dose adjustment based on the clearinine Clcr (ml/min):

CLCR> 80 ml/min: Use as daily dose, divided into 2-4 times.

CLCR from 50 - 79 ml/min: 2/3 daily dose, divided into 2-3 times.

CLCR from 30 - 49 ml/minute: 1/3 daily dose, divided into 2 times. CLCR

Not used for patients with end -stage renal failure.

Patients with liver failure

No dose adjustment.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

No special adverse effects are related to Piracetam overdose. The highest dose reported is taking 75 g of piracetam. A case of diarrhea, abdominal pain is associated with taking 75 g of piracetam/day, possibly due to high doses of sorbitol in the formula.

Handling

There is no specific antidote for Piracetam. Can wash stomach, symptomatic treatment including hemorrhage.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Dorabep 800 mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neurological: restlessness, easily agitated.

Mental: Anxiety. Metabolism: weight gain.

Uncommon, 1/1000

Body: weakness, dizziness.

Neurological: Drowsy. Mental: depression.

Rare, ADR

Blood: coagulation disorders or severe bleeding.

Mental: agitated, hallucinated, confused.

Neurology: Insomnia, imbalance, epilepsy, headache.

Tai: Vertigo (dizziness).

Digestive: Nausea, vomiting, diarrhea, abdominal pain, abdominal distention.

Skin: Dermatitis, itching, urticaria, epigastric edema.

immune: Anaphylaxis, hypersensitivity.

Instructions on how to handle ADR

When experiencing side effects of the drug, the dose should be reduced or stopped using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Dorabep 800 mg drug is contraindicated in the following cases:

Hypersensitivity to piracetam or any ingredients of the drug or other derivatives of pyrrolidon.

Patients with severe renal impairment (CLCR

People with Huntington.

Patients with cerebral hemorrhage.

Be cautious when used

Because Piracetam is discharged through the kidneys, the drug's sale time increases directly to the degree of renal failure and creatinine clearance. Need to monitor kidney function in patients with renal failure and the elderly.

Avoid stopping the drug suddenly because it can cause muscle convulsions or convulsions in some patients with myocardial infarction.

Because Piracetam works on platelet collection, it is cautious when used for severe bleeding patients, patients at risk of bleeding (digestive ulcers ...), patients with coagulation disorders, patients with a history of cerebrovascular vascular (CVA), patients undergoing large surgery including dental surgery and patients using anticoagulant drugs or coccan supply drugs including acidic acidylsalical acid.

In the drug with sodium Lauryl Sulfate, cautious with people with sensitive skin because it can cause local reactions such as stinging or burning sensation.

The ability to drive and operate machinery

The drug can cause drowsiness, nerves and depression, need to be cautious when taking the drug for people who are driving or operating machinery.

Pregnancy

There is no adequate data for using piracetam in pregnant women. Animal studies do not show direct or indirect harmful effects on pregnancy, embryo development, postpartum development.

Piracetam passes the placenta. Do not take the drug during pregnancy unless really needed, when the benefits beyond the risk and clinical status of the mother need to be treated with Piracetam.

Breastfeeding period

Piracetam excreted into breast milk. Piracetam should not be used while breastfeeding.

Interactive drug

The ability to interact with drugs causes low pharmacokinetics because 90% of the drug excreted through the urine in the form of constant.

In patients with prothrombin time, Warfarin has been stabilized when using piracetam.

Confusion, irritability and sleep disorders have been reported when used simultaneously piracetam with thyroid hormone.

In a study in patients with serious recurrent vein thrombosis, taking Piracetam 9.6 g/day does not change the dose of acenocoumarol to reach Inr 2.5 - 3.5. Compared to the use of single acenocoumarol, the addition of Piracetam 9.6 g/day significantly reduces platelet aggregation, releases thromboglobulin β, fibrinogen levels, blood viscosity and plasma.

Oral dose of Piracetam 20 g/day for 4 weeks does not change the peak concentration and serum concentration of anti -epileptic drugs (Carbamazepin, Phenytoin, Phenobarbital, Valproat) in epileptic patients who are using stable dose.

Storage

Store in a dry place, below 30 ° C, avoiding light.

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