Dorocodon Domesco medicine treats symptoms of dry cough (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Codeine camphosulfonate, sulfoguaiacol, Grindelia
Ingredient Dry cough

Ingredient

Composition information	Content
Codeine camphosulfonate	25mg
Sulfoguaiacol	100mg
Grindelia	20mg

Uses

Indications

Dorocodon has the effect of treating symptoms of dry cough, causing discomfort.

Pharmacokological

Codeine is a substance of phenanthren, which reduces the cough due to the direct effect on the center of cough in the brain; Codeine dries the respiratory discharge and increases the slope of bronchial secretions. Codeine is not enough to reduce the cough. Codein is a cough reduction in case of Khan that causes insomnia.

sulfogaiacol: Loose the secretions in the respiratory tract mucosa and have a long -range effect.

Soft high grindelia: medicinal herbs have anti -them with colds.

pharmacokinetic

codeine

Codeine is well absorbed through the gastrointestinal tract. After drinking, the maximum concentration in the blood is achieved after 1 hour. Codeine is metabolized in the liver by reducing methyl (at the O-and N-methyl position in the molecule) to form morphine, norcodeine and other metabolites such as Normorphin and Hydrocodon.

The transformation into indirect morphine is influenced by cytochrom P450 ISOENZYM CYP2D6 and this effect is very different due to the effects of the genetic structure.

Codeine and its metabolic products are excreted mainly through the kidneys and into the urine in the form of an associated with glucuronic acid. Selling time for 3-4 hours after drinking. Codein passes the placenta and is distributed into breast milk. There is no research data on pharmacokinetics of sulfogaiacol and high and soft grindelia.

Before taking Dorocodon Domesco medicine treats symptoms of dry cough (2 blisters x 10 tablets)

How to use

Oral drugs.

Dosage

drugs for adults.

Normal dose: 1 tablet/time, repeat after 6 hours if needed, no more than 4 times/day.

If not coordinated with other drugs contains Codeine or with other central anti -cough drugs, the daily dose of Codeine must not exceed 120 mg.

The elderly or patients with hepatic failure: The initial dose decreases half, then it may increase depending on the level of tolerance and need.

What to do when using overdose?

Respiratory failure (reducing breathing, respiration Cheyne-stokes, blue purple). Drinking leads to a state of dazzling or coma, soft muscle, cold and moist skin, sometimes slowly slow and lower blood pressure. In severe cases, apnea, vascular collapse, cardiac arrest and may die.

Management

Having recovery of oxygen and respiration must be controlled. Naloxon indications are immediately intravenous in severe cases.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using Dorocodon often has unwanted effects (ADR) such as:

involves codeine

In the treatment dose, adverse effects are similar to the Opium group, but rarer and lighter. Can cause headaches, dizziness, thirst and have a different feeling, nausea, vomiting, constipation, drowsiness, urinary retention. Fast circuit, slow circuit, nervousness, weakness, lower blood pressure.

Uncommon: itching, urticaria, respiratory failure, calm, refreshing, restlessness. Stomach pain, bile spasm.

Rare: Anaphylaxis reactions, hallucinations, disorientation, visual disorders, convulsions. Circulatory failure, blushing, foul tissue, fatigue.

Drug addiction: Use Codeine for a long time with a dose of 240 - 540 mg/day with addictive drugs. The common manifestations of drug shortages are restlessness, tremor, muscle convulsions, sweating, runny nose. May be dependent on psychological, physical and familiar drugs.

Related sulfogaiacol

may experience allergies, urticaria.

highly related Grindelia

can cause stomach irritation and diarrhea. At high doses can cause kidney irritation.

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Dorocodon drug is contraindicated in the following cases:

Hypersensitivity to one of the ingredients of the drug.

Precautions when using drugs

Attention:

Prolonged treatment at high doses can cause drug dependence. Left, obstructive pulmonary, pleural effusion. If the cough is not improved with a normal dosage cough, do not increase the dose but the weight reassembles for the patient's clinical condition.

Caution at use:

Nephrotic needs in case of increased intracranial pressure, depression, new chest surgery or abdominal surgery. The drug can give test results using positive stimulants.

Pregnant women.

Codeine should only be used at the lowest doses that are effective and in the shortest time.

It is not recommended to use drugs for children with respiratory problems (shortness of breath or wheezing during sleep ...).

sulfogaiacol: notify the doctor if the allergic reaction occurs (rash, urticaria, itching, shortness of breath, chest tightness, swelling of the mouth, face, lips, or tongue).

Soft high grindelia:

There is no research data in children, so Grindelia medicinal herbs should only be used for adults. Do not use for pregnant and lactating women.

Use drugs for women during pregnancy and lactation

codeine

Studies conducted on animals show that codeine has a teratogenic effect. However, in clinical, epidemiological data on a limited number of women do not show that Codeine has any special malformations.

In the last 3 months of pregnancy, if the mother used for a long -term codein, no matter what the dosage could be the cause of detoxification syndrome in infants.

High doses of Codeine at the end of pregnancy even short -term can cause respiratory inhibitors in infants. Therefore, Codeine should only be used during pregnancy when really necessary.

Be cautious when using medication for nursing women (because Codeine can be excreted in breast milk).

sulfogaiacol and high and soft grindelia: There is no research data on pregnant and lactating women. Do not use for pregnant and lactating women.

The effect of the drug on the ability to drive and operate machinery

Drugs that cause drowsiness should be cautious when driving and operating machinery.

Drug interaction

Do not coordinate with the following substances:

Avoid drinking alcohol and alcoholic solutions because it increases the sedative effects of anti -cough drugs. The decrease in concentration and vigilance can be dangerous to the driver and operating machinery.

Note when coordinating:

Other central neurological inhibitors (Morphin analgesics, some antidepressants, H1 antihistamine drugs have sedative effects, barbiturat, benzodiazepin, clonidin and drugs with them, anesthetic, sleeping pills, anxiety antidote, neuroleptic, three -ring depressing drugs, Monoamine inhibitors of oxidase)

Copper - Morphine antagonism (nalbuphin, bupremorphin, pentazocin): Reduce pain effect due to competition blockers, with the risk of addictive syndrome.

Morphin's other substances (analgesic or anti -cough): respiratory inhibitors due to the effect of co -effects, especially in the elderly.

Codeine reduces cyclosporin metabolism due to inhibition of cytochrom p450.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

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