Doropycin 1.5 M.I.U Domesco Treatment Treatment (2 blisters x 8 tablets)

Pharmacy

is an antibiotic macrolid group with antibacterial spectrum similar to antibacterial spectroscopy of erythromycin and clindamycin. The drug has the effect of pliers in bacteria that are dividing cells. In plasma concentrations, the drug has a bactericidal effect, but when the concentration of the drug can kill bacteria.

The mechanism of action of Doropycin 1.5 M.I.U is the effect on the subunits of 50S of ribosom bacteria and preventing protein synthetic bacteria.

In places where the drug level is very low, Spiramycin has a resistance to Gram -positive strains, coccus strains such as Staphylococcus, Pneumococcus, Meningoccus, most Gonococcus strains, 75 % Streptococcus and Enteroccus. The strains of Bordetella Perussis, Corynebacteria, Chlamydia, Actinomyces, some Mycoplasma and Toxoplasma strains are also sensitive to Spiramycin.

Spiramycin does not work with Gram -negative intestinal bacteria. There has been a notice of bacterial resistance to spiramycin, including cross -resistance between Spiramycin, erythromycin and oleandomycin. However, erythromycin resistance strains are sometimes still sensitive to spiramycin.

pharmacokinetic

Spiramycin is not completely absorbed in the digestive tract.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Unknown toxic spiramycin dose.

When using high doses, can cause digestive disorders: nausea, vomiting, diarrhea.

There may be prolonged QT, gradually stopping treatment (encountered in newborns taking high doses or in adults intravenously at risk of extension of QT).

Management

In case of an overdose, an electrocardiogram should be used to measure the QT interval, especially when there are other risks (reduced potassium, congenital QT interval, combining the use of drugs that extend the QT and/or causing torsion).

There is no antidote.

Symptomatic treatment.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting a dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Caution when using

Use cautiously when using Spiramycin for people with liver dysfunction, because the drug can be toxic to the liver.

Be cautious when using doropycin 1.5 M.I.U for people with heart disease, arrhythmia (including people who tend to extend QT). At the beginning of treatment, if the whole body has a fever, it is necessary to stop the drug because it is suspected of having a pustules. This case must be contraindicated to use Spiramycin.

The rare case of hemolytic anemia has been reported in patients with glucose deficiency - 6 - phosphate - dehydrogenase. Should not use Spiramycin for these patients.

The ability to drive and operate machinery

The drug hardly affects the ability to drive and operate machinery.

Pregnancy and nursing mothers

Pregnancy

Spiramycin passes through the placenta, but the concentration of doropycin 1.5 M.I.U in the fetal blood is lower than the mother's blood. Spiramycin does not cause complications when used for pregnant people.

Breastfeeding period

Spiramycin is excreted in breast milk with high concentrations. Should stop breastfeeding while taking Doropycin 1.5 M.I.U.

Medicinal interaction

using spiramycin simultaneously with oral contraceptive medicine will cause loss of conception.

Levodopa concentration in plasma has been reported when using Spiramycin with Levodopa.

A torsion report in patients with congenital QT syndrome when treated with Spiramycin and Mequitazin. Therefore, be careful when using these drugs.