Dotium Domesco medicine for symptoms of vomiting, nausea (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Domperidon
Ingredient Vomiting/nausea

Ingredient

Composition information	Content
Domperidon	10mg

Uses

indications

Dotium drugs are indicated: Vomiting and nausea treatment.

Pharmacokic

Domperidone is a dopamine receptor anti -receptor with anti -vomiting properties. Domperidone does not easily pass the bloody barrier. In domperidone users, especially adults, unwanted effects like the surgeon syndrome are rare, but domperidone promotes prolactin secretion in the pituitary gland.

Anti -vomiting effects may be due to the coordination of peripheral effects (gastric hyperactivity) and the Dopamine receptor resistance in the CTZ receptor sensor area (Chemoreceptor Trigger Zone) is located outside the bloodstream barrier in the vomiting area of the onion.

Through animal research shows that the concentration found in the brain is low, showing the effect of domperidone mainly on peripheral dopamine receptors.

Research in humans shows that drinking domperidone increases the lower esophageal muscle tone, improves the exercise of the duodenum and increases the stomach empty. The drug does not affect the secretion of the stomach. 

pharmacokinetics

absorption:

In hungry people, the domperidone absorbs quickly after drinking with peak blood concentration achieved after 30–60 minutes. The absolute bioavailability of low oral domperidone (about 15%) is due to the broad initial metabolism in the intestinal wall and liver.

Domperidone's

Domperidone is increased in healthy people after drinking after meals, patients with digestive problems should take domperidone before eating 15–30 minutes. The decrease in acid levels in the stomach does not reduce the absorption of Domperidone Base.

The oral bioavailability of Domperidone Base does not decrease if the patient previously takes cimetidine or sodium bicarbonate. Time to reach the peak concentration will be a bit slow and the AUC will increase slightly when the drug is taken after eating.

Distribution:

Domperidone is used without accumulating or creating separate metabolism, the peak concentration in plasma is achieved after 90 minutes of 21 ng/ml, after taking 30 mg/day for 2 weeks, it is almost equivalent to the peak concentration after the first dose of 18 ng/mL.

The ratio of plasma bound domeridone is 91–93 %. Researching the distribution of drugs by marking radioactivity on animals shows that the drug is widely distributed in the body tissue but low concentrations in the brain. In mice, a small amount of drugs go through the placenta.

Metabolism:

Domperidone undergo a quick and multi-liver process with liver with hydroxylation and reducing N-alkyl.

In vitro, the test of metabolism with inhibited drugs shows that CYP3A4 is a major form of Cytochrome P450 related to the de-alkyl deholes of domperidone, while CYP3A4, CYP1A2 and CYP2E1 are related to the aromatic hydroxylation of Domperidone.

Era:

Eliminate urine and fertilizer about 31% and 66% of oral dose. A small part of the drug is excreted in intact form (10% in feces and 1% in urine).

Semi -selling time in plasma after single dose is 7–9 hours in healthy but prolonged people in patients with severe kidney function.

Before taking Dotium Domesco medicine for symptoms of vomiting, nausea (10 blisters x 10 tablets)

How to use

oral medication and should be taken before meals. If taken after meals, the drug may be slowly absorbed.

Patients should take medicine at fixed time.

Dosage

always use the right dose in the prescription. Dotium should only use the lowest dose effectively in the shortest time to control vomiting and nausea. Maximum treatment time should not exceed a week.

Adults and minors (aged 12 years and older and weighing 35 kg or more):

Use 10 mg/time, can be used up to 3 times/day, a maximum dose of 30 mg/day.

infants, young children, children (under 12 years old) and adolescents weighs less than 35 kg:

Due to the exact dosage, the form of film tablets is not suitable for young children and minors weighing less than 35 kg.

Patients with liver failure:

Dotium is contraindicated to patients with medium and severe liver failure.

Patients with renal failure:

Due to the prolonged domeridone's selling time in patients with severe renal impairment, if used repeated, the number of dotium drugs should be reduced to 1–2 times/day and adjust the dose depending on the degree of renal failure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

There is no specific antidote. In the case of an overdose, it is necessary to take symptomatic treatment immediately. Should monitor the electrocardiogram due to the ability to extend the QT range.

Gastrointestinal lavage as well as using activated carbon can be helpful.

Strict medical monitoring and treatment support are encouraged.

anti -cholinergic drugs, Parkinson's treatment may be helpful in controlling foreign reactions.

What to do when you forget 1 dose?

Drink as soon as you remember. If the time is close to the next medication, skip the forgotten dose and take the next dose at the usual time. Do not use double dose to compensate for the forgotten dose. 

Side Effects

When using dotium, you may experience unwanted effects (ADR).

Common, ADR> 1/100

No report.

Uncommon, 1/1000

Reproduction and mammary gland: Breast pain.

Rare, 1/10000

Endocrine: The level of prolactin increases.

Reproduction and mammary gland: Excessive secretion of milk, female mammary glands, amenorrhea.

Very rare, ADR

Immunodes: Allergic reactions, including anaphylaxis, anaphylactic shock, anaphylactic reaction and angioedema.

Mental: agitated, stressed.

Neurological: The effect of the extras, convulsions, drowsiness, headache. stomach - stomach: diarrhea, transient abdominal pain.

Skin and subcutaneous tissue: urticaria, itching, rash.

Not determined frequency

Neurological: Muscle disorders, vacuum syndrome.

Eye: Eye disease.

Cardiovascular: ventricular arrhythmia, extension of qt, twisted, sudden death due to cardiovascular.

Reproduction and mammary gland: Reduce libido.

Instructions on how to handle ADR

Stop medication and symptomatic treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Dotium drugs contraindicated in the following cases:

Too hypersensitivity to domperidone;

Bleeding or gastrointestinal perforation;

Mechanical intestinal obstruction;

Prolactin secretion (prolactinom);

Pregnant women;

Patients with average and severe liver failure;

Patients with prolonged heart impulse transmission time, especially about QT, patients with clear electrolytes or patients with cardiovascular disease such as congestive heart failure;

Simultaneously used with drugs that extend QT;

Simultaneously with CYP3A4 inhibitors (regardless of the effect of QT length).

Be cautious when using

only use domeridone for no more than 12 weeks for Parkinson's patient, when other anti -vomiting measures are safer. Harmful effects in the central nervous system may appear.

Renal failure: Domperidone's disposal time is prolonged in patients with severe renal impairment. In the case of repeated use, the frequency of using domperidone should be reduced to 1–2 times/day depending on the degree of renal failure. Can adjust the dose if needed.

Cardiovascular effects:

domperidone extends the QT distance on the electrocardiogram. In the process of after -sales monitoring, there are very few reports on the QT interval and torsion related to the use of domperidone. These reports include patients with risk factors such as electrolytes or simultaneous medications.

Epidemiological studies show that domperidone may increase the risk of severe ventricular arrhythmia or sudden cardiovascular disease. This risk is higher for patients over 60 years old, patients taking daily doses> 30 mg and patients with simultaneous use of the drug extending the QT or CYP3A4 inhibitors.

Use domperidone with the lowest doses effectively in adults and children.

Contraindicated domperidone for patients with prolonged heart impulse transmission time, especially QT interval, patients with obvious electrolyte disorders (hypotension, hyperkalemia, hypoglycemia), slow heartbeat or patients with cardiovascular disease such as congestive heart failure due to ventricular disorder.

electrolyte disorders (hypotension, hyperkalemia, hypoglycemia) or slow heartbeat have been known as a factor that increases the risk of arrhythmia. Domperidone treatment should be stopped and exchanged with health workers if there are any symptoms or signs related to arrhythmia. Patients should immediately report symptoms on the heart.

Patients with galactose tolerance problems, patients with enzyme deficiency lapp lactase or malcose -galactose should not be used.

The ability to drive and operate machinery

The drug can cause drowsiness, headache (rare). Be cautious when driving or operating machinery. 

Pregnancy

Restrict the use of domperidone in pregnant women. A study in mice shows that reproductive toxicity at high doses of toxicity in the mother mouse. The potential risks in humans are unknown. Therefore, domperidone should only be used during pregnancy when the treatment benefits have been proven.

breastfeeding period

domperidone excreted through breast milk and breastfed babies receive less than 0.1% dose according to the mother's weight. The adverse effects, especially the effect on the heart can still occur after breastfeeding.

Consider the benefits of breastfeeding and the benefits of treatment for mothers to decide to stop breastfeeding or stop/avoid domeridone treatment. Be careful in case of risk factors that extend the QT range in breastfed babies.

Interactive drug

The main metabolic line of domperidone via CYP3A4. The research data on in vitro shows that these drugs simultaneously inhibit the enzyme strongly can increase the concentration of domperidone in the blood.

Interaction with oral ketoconazole or Erythromycin oral oral in healthy people has confirmed the indirect inhibition of the domeridone's first passing effect via CYP3A4 by these drugs.

Increase the risk of extending the QT distance due to pharmacokinetic interaction or pharmacokinetic energy. 

Contraindicated with the following drugs:

Medications that extend the QT range:

Anti -arrhythmia IA (Disopyramide, Hydroquinidine, Quinidine); SERTINDOL); lumefantrine); (Bepridil, Diphemanil, Methadone).

Strong CYP3A4 inhibitors (regardless of the effect of extending the QT):

Protease inhibitors, Azole -group antifungal drugs, macrolide drugs (erythromycin, clarithromycin and telithromycin).

Do not recommend using the following drugs:

Medium CYP3A4 inhibitors such as Diltiazem, Verapamil and some macrolide drugs.

Use cautiously when used simultaneously with the following drugs:

Heart rate slow, hypokalemia and some macrolid drugs contribute to extending QT interval such as azithromycin, Roxithromycin (clarithromycin contraindicated as a powerful CYP3A4 inhibitor). 

Levodopa: Increasing Levodopa's plasma concentrations (up to 30–40 %).

Opioid can reduce the effect of domperidone in stomach empty.

Cavalry of the drug: Because there is no studies on oral medications, they do not mix this drug with other drugs.

Storage

In the dry place, temperatures below 30 ° C, avoiding light.

Storage in the original packaging of the drug.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.