Dourso 200mg Domesco Treatment Treatment of Cholesterol gallbladder stones (3 blisters x 10 tablets)

Pharmacy

Ursodeoxycholic acid is a natural bile salts present with a very low content in the body. Unlike other endogenous bile salts, ursodeoxycholic acid is very watery and has no cleaning effect.

Ursodeoxycholic acid works on the liver -intestinal cycle of endogenous bile acids: increasing bile secretion, reducing the reabsorption of bile fluid by inhibiting active reabsorption in the intestine, thereby reducing the concentration of endogenous bile acids in the blood.

Ursodeoxycholic acid is one of the treatments for gallstones that are essentially cholesterol by reducing cholesterol levels in bile fluid. This effect is a combination of various mechanisms: reducing cholesterol reabsorption, increasing cholesterol metabolism in the liver into bile acids through the path of increasing the activity in the liver of the enzyme of cholesterol 7 alpha-hydroxylase. Moreover, ursodeoxycholic acid maintains cholesterol in the form of soluble in bile fluid.

Dynamic pharmacy

Ursodeoxycholic acid is passive in the small intestine. Metabolic through the liver for the first time from 50 to 60%. In the liver, ursodeoxycholic acid is associated with glycine and taurine. At the dose of 10 - 15 mg/kg/day, Ursodeoxycholic acid accounts for about 50 - 70% of bile acids circulating in the body.

The dose has 5 - 10 mg/kg/day, the average recommended dose is 7.5 mg/kg/day in people with average status. For obese people, the recommended dose is 10 mg/kg/day, depending on the weight, the dose is from 2-3 tablets/day.

The normal treatment time is 6 months, but if the stones are larger than 1 cm, the treatment time may last up to 1 year.

Chronic liver disease

Treatment dose 13 - 15 mg/kg/day. Should start at a dose of 200 mg/day, then increase the dose by steps to achieve the optimal treatment dose after about 4 - 8 weeks of treatment.

In the case of liver disease caused by viscous mucus, the optimal treatment is 20 mg/kg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

No report.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Precautions when used

for long -term therapy, although Ursodeoxycholic acid has no cancer effect, rectal monitoring is recommended.

In case of treatment of cholesterol gallbladder stones, it is recommended to check the effectiveness of visual diagnosis after 6 months.

In the treatment of chronic liver disease: Patients with cirrhosis combined with impaired liver or cholestatic impairment (blood bilirubin content on 200 micromol/l), liver function (and if possible, plasma concentration of bile acids) must be monitored.

In the case of bile stasis causing rashes, the dose of ursodeoxycholic acid should be gradually increased at the starting dose of 200 mg/day. In this case, the simultaneous use of Cholestyramine is necessary with Cholestyramine conditions that must be used for 5 hours with ursodeoxycholic acid.

The ability to drive and operate machinery

does not affect.

Pregnancy

Animal studies have shown the ability to cause teratogenicity. There is not enough research data to assess the likelihood of monitoring or fetal toxicity of this drug when used during pregnancy. Do not use ursodeoxycholic acid during pregnancy except for very limited and appraised indications.

Breastfeeding period

Do not use Ursodeoxycholic acid during breastfeeding except for very limited and appraised indications.

Drug interaction

Unsonized with cholestyramine: The effect of ursodexolic acid is reduced due to cohesion with cholestyramine and is excreted. If you need to use cholestyramine, use 5 hours to use ursodeoxycholic acid.

Do not use with estrogen stimulants, as these drugs cause bile cholesterol.

Avoid use with other bile acids such as antacids, activated carbon because it can reduce the effectiveness of treatment.