DoxycyClin 100mg Domesco Treatment of infection (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Doxycycline
Ingredient Domesco

Ingredient

Composition information	Content
Doxycycline	100mg

Uses

indications

DoxyCyclin 100mg Domesco is indicated in the following cases:

Treatment of bacterial diseases caused by sensitive strains of gram -positive and gram -negative bacteria and some other bacteria.

Respiratory infections: pneumonia and lower respiratory infections due to sensitive strains of Streptococcus Pneumoniae, Haemophilus Influenzae, Klebsiella Pneumoniae and other bacteria. Mycoplasma pneumoniae pneumonia, chronic bronchitis, sinusitis.

Urinary tract infections: infections caused by sensitive strains such as Klebsiella strains, Entobacter spp., Escherichia Coli, Streptococcus Faecalis and other bacteria.

Genital infections: Chlamydia trachomatis infections include uncomplicated urethral infections, endometrial or anus infections. Uriatitis is not caused by gonorrhea due to ureaplasma ureaticum. Soft orange disease caused by Calalymatobacterium Granulomatis. Alternative drugs in the treatment of gonorrhea and syphilis.

Because doxycyclin is an antibiotic belonging to the tetracyclin group, can treat infections that respond to tetracyclin, such as:

Tabeletal infections: Due to gonococcus sensitive strains, Staphylococcus and Haemophilus Influenzae. Doxycyclin is indicated in the treatment of trachoma, although pathogens are not always excluded when evaluated by fluorescent immunity. Melioidosis, Leptospira infection, other infections due to sensitive strains with Yersinia, Brucella (combined with Streptomycin), Clostridium strains, Francisella tularensis and malaria due to chloroquin resistant falciparum. (Escherichia coli produces endotoxins in the intestine), Leptospira.

The main impact mechanism of doxycycline is the impact on protein synthesis. Doxycyclin passes through the double layers of bacterial cells and the inner cytoplasm thanks to the active transportation system depends on energy.

Once inside the cell, doxycyclin inhibits protein synthesis by attaching the 30s of the ribosom bacterial ribosom and preventing the addition of amino acids to the growth of the peptide chain. At very high concentrations, Doxycycline reduces protein synthesis in mammal cells but these cells lack positive transportation systems found in bacteria.

Doxycyclin has a wide range of antibacterial range with gas -loving bacteria and gram -positive and gram -negative bacteria and with some anti -drug -acting bacteria with cell walls such as Rickettsia, Coxiella Burnetii, Mycoplasma Pneumoniae, Chlamydia spp., Legionella spp spp. Doxycycline has no clinical fungal treatment.

Despite the similar toxicity, the less toxic toxycyclin with the liver (local irritation, stomach irritation, intestinal bacterial disorders) compared to the water -loving tetracyclin because these types must be used in high doses to achieve the concentration that works. Doxycycline is also preferred than other tetracyclin because it is better absorbed and has a longer waste time, allowing the use of drugs a few times a day.

In addition, Doxycyclin can also be used for kidney failure (although still in the kidneys). In general, Tetracyclin works with Gram -positive bacteria at a lower concentration than Gram -negative bacteria. At first, both doxycycline and tetracyclin work with most streps. Pneumoniae, but now, anti -drugs are common in many regions of Vietnam. Plasmodium falciparum in Vietnam is often resistant to many drugs such as chloroquin, sulfonamid and other anti -malaria drugs, but can still use doxycyclin to prevent it.

resistant to tetracyclin: bacteria resistant to a tetracyclin is also resistant to other tetracyclin. Escherichia coli and maybe other strains of bacteria have resisted tetracyclin mainly through plasmid intermediaries.

According to ASTS report (1997 - 1998), in Vietnam, many bacteria strains such as E. Coli, Entobacter, Shigella Flexneri, Salmonella Typhi, Staphylococcus aureus were resistant to DOXYCYCLIN. Because of the high level of resistance of bacteria, tetracycline cannot be used for experience. However, the tetracycline is still effective in diseases caused by Rickettsia, Mycoplasma and Chlamydia. It is necessary to refer to information on the situation of doxycyclin resistance, tetracyclin in particular and antibiotic resistance in general before taking the drug because the rate of drug resistance changes in the region and over time.

Pharmacokinetics

absorption

doxycyclin is well absorbed through the gastrointestinal tract (95 % of oral dose); Food and milk are less affected by absorption. Because the tetracyclin is easy to create complexes with valence 2 or 3 chemotherapy such as calcium, magnesium, aluminum, antacids and other drugs contain the above cations that affect the absorption of doxycyclin.

About 80 - 95 % doxycyclin in the blood is attached to plasma proteins. Doxycyclin can be taken 2 times/day because the drug has a long selling time (16 - 18 hours). Achieving a maximum plasma concentration of 3 micrograms/ml, 2 hours after taking 200 mg Doxycyclin the first dose and plasma concentration maintained on 1 microgram/ml for 8 - 12 hours. Plasma concentration of plasma doxycycline when taken is equivalent when injected.

Distribution

Doxycyclin is widely distributed in the body into tissues and secretions, including urine and prostate. The drug accumulates in mesh - endothelial cells of the liver, spleen and bone marrow and in the bone, dentin and enamel have not grown. Doxycyclin is more soluble in fat than tetracyclin.

Elimination

Selling time is from 12 to 24 hours.

There is an important difference: Doxycyclin is not excreted mainly through the kidneys like other tetracyclin, but excreted mainly through stool (through the liver), secondary through urine (through the kidneys) and is not as accumulated as other tetracyclin in renal failure people, thus one of the safest tetracyclin to treat renal infections.

However, DoxycyCline is less excreted through the kidneys, so the high doses of doxycyclin must be used to treat urinary tract infections. Hematoparoa has little effect on eliminating DoxycyClin.

Before taking DoxycyClin 100mg Domesco Treatment of infection (10 blisters x 10 tablets)

How to use

use it with plenty of water before going to bed in the evening to reduce the ability to irritate the esophagus and ulcer. If stimulating stomach occurs, DoxycyCline is recommended for food or milk. Studies indicate that the absorption of Doxycycline does not significantly affect with food or milk.

Dosage

Always use the right dose in the prescription.

Adults: The usual dosage to treat acute bacterial infections in adults is 20000 mg on the first day (using a single dose or divided into two doses in a period of 12 hours), the maintenance dose is 100 mg/day. In more severe infections (especially chronic infections in the urinary tract) is 200 mg/day during treatment.

Overdose recommended can lead to an increase in unwanted effect rate.

Treatment should be continued for at least 24 - 48 hours after symptoms and fevers decrease. When used in streptococcal infections, treatment should be continued for 10 days to prevent the development of rheumatoid fever or glomerulonephritis.

Sexually transmitted diseases: 100 mg x 2 times/day for 7 days recommended to be used in the following infections: Gonorrhea infections are uncomplicated (except for rectal anal infections in men); Non -complicated urethra infections, endometrial infections or anus caused by chlamydia trachomatis; Ureaplasma urethritis is not caused by Ureaplasma Urealyticum.

Lice recurrent fever and cicadas: Use a single dose of 100 mg or 200 mg according to severity. Depending on the severity of the infection, the schizophrenic eradications such as quinine must always be combined with DoxycyCline; The recommended dose of Quinin varies depending on the region. There is no data on the use of preventive drugs lasting more than 21 days. There is no data on the use of preventive medicine lasting more than 21 days.

Elderly: According to the usual dose. No dose adjustment in case of renal failure.

* Renal failure: Studies have so far shown that drinking doxycyclin at the usual dose does not lead to excessive accumulation of antibiotics in patients with renal impairment.

The anti -assimilation effect of tetracyclin can cause blood urea. Studies show that this does not happen when using DoxycyCline in patients with impaired renal function.

Hemolysis does not change the sale time of doxycyclin.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when you forget 1 dose?

Drink as soon as you remember. If the time is close to the information, please consult a doctor or pharmacist.

If the time is close to the next medication, skip the forgotten dose and take the next dose at the usual time. Do not use double dose to compensate for the forgotten dose.

Side Effects

When using DoxyCyclin 100mg domesco, you may experience unwanted effects (ADR).

Hypersensitivity reactions, including anaphylaxis, anaphylaxis, anaphylactic reaction, allergic hemorrhage, hypotension, pericarditis, angioedema, exacerbations of systemic lupus erythematosus, shortness of breath, serum, peripheral angio, tachycardia and urticaria.

Infections and parasitic infections: Similar to all antibiotics, excessive growth of Clostridium difficile) and dermatitis (excessive development Candida ) genitals.)

Blood disorders and lymphatic systems: hemolytic anemia, thrombocytopenia, neutropenia, eosin blood cell hyperactivity and porphyrin metabolic disorders.

Endocrine disorders: When using tetracyclin for a long time, creating a black brown tissue change. No thyroid dysfunction occurs.

Nervous disorders: headache. The fontanel disease in newborns and increased benign intracranial pressure among teenagers and adults has been reported in some patients using tetracyclin with sufficient doses of treatment. Symptoms are lost when stopped taking the drug. Symptoms include a double look and a point. Permanent vision loss has been reported.

Ear and inner ear disorders: tinnitus.

Gastrointestinal disorders: Symptoms of gastrointestinal tract are often mild and rarely stop for treatment. Abdominal pain, stomatitis, anorexia, nausea, vomiting, diarrhea, indigestion and rarely difficulty swallowing. Esophagitis and esophagitis have been reported in patients using doxycyclin. The tetracycline group can cause discoloration of teeth and reduce enamel, but usually only occur after long -term treatment.

Liver disorders: Increase the liver function during testing, rarely hepatitis, jaundice, liver failure and pancreatitis.

Skin and subcutaneous disorders: The rash includes lumpy rash and erythema, flaking dermatitis, diverse roses, Stevens-Johnson syndrome and poisoning, peeling nails, light sensitivity.

Disorders of musculoskeletal and connective tissue: joint pain and muscle pain.

Renal and urinary disorders: Hyperburstemia.

Reproductive and mammary disorders: Vaginitis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated:

Doxycyclin 100mg domesco contraindicated in the following cases:

Hypersensitivity to doxycyclin, tetracyclin or any ingredients of the drug.

The use of drugs of Tetracyclin in the stage of tooth development (pregnant women, newborns and children to 12 years old) can cause permanent teeth change (yellow - gray - brown). This unwanted effect is more common when using long -term or short -term use. Reducing enamel production is also reported. Doxycycline contraindicated in these patients.

Children under 12 years of age: Contraindicated children under 12 years old.

Pregnant women: Doxycycline contraindicated during pregnancy.

Lactating women: Tetracyclin medications can be contraindicated for breastfeeding.

Be cautious when using

Light sensitivity: Expression by excessive tanned reactions in some users of tetracyclin drugs, including doxycyclin. Patients exposed to direct sunlight or ultraviolet rays should know that this reaction can occur when taking tetracyclin medication. Treatment should be discontinued when signs of skin rash.

Patients with liver failure: Doxycycline should be used carefully because of the ability to poison the liver. Rare liver function abnormalities occur in both oral and sugar of tetracycline drugs, including doxycyclin.

In patients with renal impairment:

doxycyclin excretion through the kidney is about 40 % in 72 hours in people with normal kidney function. The excretion rate is about 1-5 % in 72 hours in severe renal failure (creatinine clearance below 10 ml/minute). Studies have shown that there is no significant difference in the serum semi -serum time of doxycycline in people with normal kidney function and severe kidney failure. The anti -assimilation effect of tetracycline drugs can cause blood urea. Studies show that this anti -assimilation effect does not occur when using doxycycline in patients with renal impairment.

overcurrent bacteria: The use of antibiotics can sometimes lead to over -development of uncertainty bacteria, including Candida. If the bacteria are resistant to drugs, antibiotic and appropriate treatment should be discontinued.

fake colitis occurs with almost all antibacterial drugs, including doxycycline, with mild to heavy levels. It is important to consider diagnosis in patients with diarrhea after antibacterial drugs.

esophagitis: The case of esophagitis and esophagitis in patients with tetracyclin drugs, including doxycycline. Most of these patients take medication right before going to bed or drinking with some water.

Puffed down in newborns and increased benign intracranial pressure in adolescents and adults when taking medication. This condition quickly disappears when the drug is stopped.

Porphyrin metabolic disorders: Rarely use tetracyclin medication.

Sexually transmitted diseases: When treating sexually transmitted diseases with suspected syphilis, using appropriate diagnosis, including tests on black background microscopy. In all cases such as monthly serum tests should be done for at least 4 months.

Streptococcus beta infection: Hemolysis: Streptococcus Beta bacterial infections Beta Group A should be treated for at least 10 days.

Myasthenia: because of the ability to manipulate the nerves, be careful when taking tetracyclin medications for patients with myasthenia gravis.

Systemic lupus erythematosus: Tetracycline drugs can cause exacerbations of systemic lupus erythematosus (SLE).

Patients with galactose tolerance problems, patients with lapp lactase enzyme deficiency or Glucose-Galactose should not be used.

The ability to drive and operate machinery

Note the drug causes blurred vision, visual disorders. Be cautious when driving, operating machinery.

Pregnancy

Doxycycline contraindicated during pregnancy. The risks related to the use of tetracycline during pregnancy are mainly due to the effect of dental and bone development.

breastfeeding period

tetracyclin through breast milk thus contraindicated for nursing mothers.

Drug interaction

There have been reports on prolonged prothrombin in patients using warfarin and doxycyclin.

Tetracyclin medications reduce plasma prothrombin levels and need to reduce the dose of anticoagulants when used simultaneously. Acid resistance contains aluminum, calcium, magnesium or other drugs containing cations; Zinc drinks, iron salt or bismuth preparations. Should be used away from these drugs. Doxycycline dose is required.

doxycycline may increase the concentration of cyclosporin in plasma. Need to monitor when used simultaneously. Reduce the concentration of doxycycline. It is necessary to consider simultaneous use and increase the dose of doxycyclin.

The cavalry of the drug:

Do not have studies on oral medications, do not mix this drug with other drugs.

Storage

Store in: dry place, temperature below 30 ° C, avoid light.

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