Doxycycline 100mg Brawn treats Brucella, cholera (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Doxycycline

Ingredient

Composition information	Content
Doxycycline	100mg

Uses

Indications

Doxycycline Capsules BP is indicated in the following cases:

Brucella treatment; Cholera disease is caused by Vibrio Choler, granuloma caused by Calymma-Tobacterium Granulomatis; Chronic fluttering by Borrelia Burgdorferi, regression fever caused by Borrelia Recurrentis; Non -specific urethritis caused by urealasma ureaticum; "Not typical pneumonia" by Mycoplasma Pneumoniae; disease caused by Rickettia Rickettii; Fever Q and disease due to Rickettsia Akari; Even fever caused by Chlamydia Psittaci; Nicolas - favre diseases, grain conjunctivitis, nausced urethritis and cervicitis caused by chlamydia trachomatis; Chlamydia pneumoniae pneumonia.

Doxycycline is a broad -spectrum antibiotic, which has a bactericidal effect. The protein synthetic bacterial inhibitors are attached to the subunit of 30s and may be with 50s of sensitive bacteria ribosom; The drug can also cause changes in the cell membrane.

Doxycyclin has a wide range of antibacterial range with anaerobic and anaerobic bacteria and gram -negative, and even with some anti -drug microorganisms acting on cell walls, such as Rickettsia, Coxiella Burnetii, Mycoplasma Pneumoniae, Chlamydia spp., Legionella SP Plasmodium spp.

Doxycyclin does not have clinical mushroom treatment.

In tetracyclin, doxycyclin is less toxic to the liver and has the advantage in the use of drugs, because the plasma concentration is equivalent to taking or injecting the drug. More fat medications like doxycycline and minocyclin, have the strongest effect, followed by tetracyclin. In general, Tetracyclin works with Gram -positive bacteria at a lower concentration than Gram -negative bacteria.

At first, both doxycycline and tetracyclin work with most streps. Pneumomae, but now, anti -drugs are common in many regions of Vietnam. Plasmodium falciparum infection in Vietnam is often resistant to many drugs such as chloroquin, sulfonamid and other anti -malarial drugs, but can still use DoxycyClin to prevent it.

resistance of tetracyclin: microorganisms resistant to a tetracycline are also resistant to other tetracyclin. Escherichia coli and maybe other strains of bacteria have resisted tetracyclin mainly through plasmid intermediaries. According to the ASTS report (1997 - 1998), in Vietnam, many bacteria such as E. Coli, Enerobacter, Shigella Flexneri, Salmonella Typhi, Staphylococcus aureus were resistant to Doxcerclin. Because of the high resistance of bacteria, tetracycline cannot be used for experience. However, the tetracycline is still effective in diseases caused by Rickettsia, Mycoplasma and Chlamydia.

pharmacokinetic

absorption

doxycyclin is well absorbed through the gastrointestinal tract (95% of oral dose); Absorption decreases when using milk simultaneously. Doxycyclin can be taken 2 times/day, because the drug has half -life (16 - 18 hours). Achieving a maximum plasma concentration of 3 micrograms/ml, 2 hours after taking 200 mg Doxycyclin the first dose and plasma concentration maintained on 1 microgram/ml for 8 - 12 hours.

A plasma concentration is equivalent to taking or injecting Doxycycline. Because the tetracyclin is easy to be complex with valence 2 or chemotherapy 3, such as calcium, magnesium, aluminum, antacids and other drugs containing the above cations, as well as food and milk containing calcium all affect the absorption of DoxyCyclin.

Distribution

Doxycyclin is widely distributed in the body into tissues and secretions, including urine and prostate. The drug accumulates in mesh - endothelial cells of the liver, spleen, and bone marrow, and in bones, dentin, and not growing tooth enamel.

Elimination

Most of the tetracyclin excreted the kidneys mainly, although the tetracyclin is also concentrated in the liver and excreted through the bile into the intestine, and they are partly reabsorbed through the re -circulating of the gut - the liver. There is an important difference in the case of doxycycline, which is DoxycyClin that does not excrete like other tetracyclin, but excreted mainly in feces (through the liver), secondary through the urine (through the kidney), and does not accumulate as much as other tetracyclin in kidney failure people, so it is one of the safest tetracyclin in this patient.

Before taking Doxycycline 100mg Brawn treats Brucella, cholera (10 blisters x 10 tablets)

How to use

Oral drugs.

Dosage

appropriate oral dose varies depending on the nature and severity of the infection. Doxycycline dose for adults is 100 mg, once a day or twice a day when the infection is severe. The dose for children over 8 years old is 4 to 5 mg/kg/day, divided into 2 doses equal, every 12 hours of the first day, then take this half of the amount (2 to 2.5 mg/kg), only a day of the day.

For serious illness, taking the dose of 2 to 2.5 mg/kg, every 12 hours.

To prevent malaria in adults, drink 100 mg, once a day. Preventive therapy begins 1 or 2 days before going to the malaria area, continuing to drink daily, and 4 weeks after leaving the malaria area.

Dosage in renal failure: Although DoxycyClin also eliminates the kidneys, people with renal failure often do not need to reduce the dose because DoxycyCline also eliminates through the liver, biliary tract and gastrointestinal tract.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose? In case of overdose, combining stomach and supportive treatment.

Dialysis does not change half a lifetime of plasma and therefore will not be beneficial in the treatment of overdose cases.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Doxycycline Capsules BP, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: esophagitis.

Other: Teeth variable in children.

Uncommon, 1/1000

Skin: skin, sensitivity.

digestive: nausea, diarrhea. Blood: neutrophils, eosinophilia loves EOSIN.

In place: Venous inflammation.

Rare, ADR

Central nervous system: Increased benign intracranial pressure, fontanel in young children.

liver: toxic liver.

Instructions on how to handle ADR

Cases to stop using the drug when encountered

Sudden wheezing, shortness of breath, chest pain, fever, eyelid swelling, face swelling or lips, rash or itching (especially throughout the body).

Serious skin reactions such as diverse roses, Stevens-Johnson syndrome or epidermal necrotic syndrome due to toxicity, serious peeling, rash or itching (especially throughout the body).

Fever, swelling of lymph nodes or skin rash. These may be symptoms of Dress syndrome (drug reaction with eosinophilia and systemic symptoms), which may be serious and life -threatening.

Severe headache accompanied by vision and blurred vision, or vision loss. Permanent vision loss has been reported.

Gastritis causes stomach disorders, anorexia, prolonged diarrhea or bleeding diarrhea.

Cardinity.

Cases of notifying doctors and pharmacists when encountering:

Inflammation or esophagus ulcer.

Blood disorders due to changes in the number of blood cells. Symptoms may include fatigue, easy to bruise.

Hemolysis anemia (low number of red blood cells). Signs include fatigue, headache, folding during exercise, dizziness with jaundice and/or yellow eye.

Low blood pressure.

Increased heart rate.

Sales or muscles.

Stomach and diarrhea.

Warnings

Contraindicated

Doxycycline Capsules BP drugs in the following cases:

Hypersensitivity to tetracyclin, or anesthetic anesthetic "type" (for example, lidocaine, process).

Children under 12 years old.

Patients with severe liver failure.

Pregnant women and nursing women.

Precautions when using

used in patients with liver function impairment

Doxycycline should be used carefully with patients with liver function impairment or patients who are taking drugs at risk of liver toxicity.

Abnormal liver function has been rarely recorded and occurred by both oral and injections when using tetracycline, including DoxycyCline.

Used in patients with renal function

Doxycyclin excreted by kidney about 40% in 72 hours in patients with normal renal function. This ratio can be reduced to only 1-5% in 72 hours in patients with severe renal function (creatinine clearance below 10 ml/minute).

Studies have shown that there is no significant difference in the sale of serum waste of Doxycyclin between patients with normal renal function and patients with impaired renal function. Dialysis does not change the time of selling serum waste of doxycyclin. Animal -assimilation activity can increase blood urea. Studies show that this activity does not occur when using doxycycline on patients with renal function.

Sensitive to light

Light sensitivity manifested by excessive tanned reaction has been observed on some patients using tetracyclin, including doxycycline. Patients must be in direct sunlight or UV rays should be recommended that this reaction may occur while using Tetracycline antibiotics and should stop the drug when the first sign of erythematosus appears.

Excessive development

The use of antibiotics can lead to over -development of non -sensitive microorganisms including Candida. If a drug -resistant microorganism appears, antibiotic should be stopped and started appropriate treatment.

fake colitis

Fake colitis is reported to almost all antibiotics, including doxycycline with mild to life -threatening severity. Considering this diagnosis in patients with diarrhea after using antibiotics is very important.

diarrhea caused by Clostridium difficile (CDAD) has been reported when used with almost all antibiotics, including Doxycycline, with severity from mild diarrhea to colitis. The treatment with antibiotics changes normal bacteria, leading to excessive growth C. Difficile.

c. Difficile produces toxins of Table A and B, which contributes to CDAD progression.

Difficile lines create toxins that increase the incidence and death, because these infections are often difficult to treat with antibiotics and may require the trick to remove the colon. CDAD must be considered in all patients with diarrhea after using antibiotics. History of drug use is necessary because CDAD has been recorded after more than 2 months of antibiotic use.

esophagitis

Cases of inflammation and esophagitis have been reported in patients using drugs in tetracyclin, including doxycycline. Most of these patients use the drug right before going to bed or taking medicine with insufficient water.

Porphyria metabolism disorders

There is a rare report on porphyria metabolism disorders in patients using tetracyclin.

Disease willow

When treating willow and suspected syphilis, it is necessary to perform appropriate diagnostic procedures, including dark field tests. In these cases, serum tests should be tested for at least 4 months.

Hemolytic streptococcal infections β

Bacterial infections caused by hemolytic streptococcal β group A should be treated for at least 10 days.

Neurological pain

Due to the ability to maple nerves, be careful when using tetracycline for patients with neurological pain.

System Reds

Tetracyclin may increase systemic lupus erythematosus.

methoxyfluran

Be cautious when using tetracycline with methoxyfluran.

The ability to drive and operate machinery

The effect of doxycycline on driving or operating machinery has not been studied. There is no evidence that doxycycline can affect this ability.

Pregnancy

Tetracyclin distributed through the placenta; Do not use doxycycline in the second half of pregnancy because doxycycline can cause permanent teeth discoloration, reduce enamel production, and can accumulate in the bone, cause bone structure disorders. In addition, there may be fatty liver in pregnant women, especially when high -dose intravenous injection.

Breastfeeding period

Doxycyclin is excreted into milk and creates an absorbable complex with calcium in milk.

Medicinal interaction

simultaneously use Doxycyclin with antacids containing aluminum, calcium, or magnesi can reduce the effects of antibiotics; With iron and bismuth subsalicylate, it can reduce the bioavailability of doxycycline; With Barbiturat, Phenytoin, and Carbamazepin, can reduce the half -life of Doxycyclin; With Warfarin, it can increase the effects of anticoagulants.

Storage

Store at a temperature not exceeding 30 ° C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.