Dozidine MR 35mg Domesco medicine treats stable angina symptoms (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Trimetazidine
Ingredient Retinal retina, tinnitus, angina

Ingredient

Composition information	Content
Trimetazidine	35mg

Uses

indications

Dozidine MR 35 mg drug is indicated in the following cases:

appoint adults in supplementary therapy/support for existing treatments to treat symptoms in patients with stable angina without adequate control or non -tolerant patients with other angina therapy. Ketoacyl - Coa thiolase in ischemic cells, energy obtained during oxidation of glucose needs to consume less oxygen than the oxidation beta.

Promoting glucose oxidation will help optimize cell energy processes, thus maintaining appropriate energy metabolism during anemia.

Pharmacological effects: In patients with ischemic heart anemia, trimetazidine acts as a metabolic substance, helping to conserve high intracellular energy levels in myocardial cell.

Trimetazidin has anti -anemia effect but does not affect hemodynamics.

pharmacokinetics

After taking the drug, the maximum concentration is achieved after 5 hours. After 24 hours, plasma concentrations are larger than or equivalent to 75% of the maximum concentration within 11 hours.

Stable status achieved at the latest after 60 hours. The pharmacokinetic properties of Dozidine MR 35 mg are not affected by food. The distribution volume is 4.8 l/kg.

Low trimetazidine protein binding ratio: The value measured in in vitro is about 16%.

trimetazidin is eliminated mainly in urine, mainly in constant form.

Dezidine MR 35 mg's exhaust time is 7 hours in healthy and 12 -hour voluntary young people in the elderly (over 65 years old). The total clearance of trimetazidine is the main result due to the dialysis, directly related to the clearinin clearance, a small part related to the liver clearance reduced with age.

A special clinical study in the elderly population, using a dose of 2 capsules a day, divided into 2 times is analyzed by approaching the dynamics of the population, showing an increase in plasma concentration without the dose adjustments.

Before taking Dozidine MR 35mg Domesco medicine treats stable angina symptoms (6 blisters x 10 tablets)

How to use

Dozidine MR 35 mg is an oral, oral medication, oral meal, no break, chewing or crushing pills.

Dosage

Common doses: Take 1 capsule/time x 2 times/day.

Patients with average renal failure (Creatinine clearance 30 - 60 ml/minute)

Dosage recommended 1 tablet/time x 1 time/day in the morning, drink with meals (see more contraindications and cautious parts).

Elderly patients

Elderly patients may have a higher level of trimetazidin sensitivity than normal due to the decline of kidney function by age.

Dosage recommended 1 capsule/time x 1 time/day in the morning, drink with meals. Be careful when calculating the dose for elderly patients.

Children

The safety and effectiveness of trimetazidin in patients under 18 years of age has not been evaluated. There is currently no data on this patient object.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose?

What to do when you forget 1 dose?

Side Effects

When using Dozidine MR 35 mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Dizziness, headache, abdominal pain, diarrhea, indigestion, nausea and vomiting, itching, urticaria, weakness.

Rare, ADR

Brush the chest drum, suspense, extra systolic, fast heartbeat, arterial hypotension, vertical hypotension, which can lead to discomfort, dizziness or falling, especially in patients being treated with anti -hypertension drugs, flushing.

Unknown frequency

Symptoms Parkinson (Run, slow and difficult movement, muscle tone), unstable gait, vacuum syndrome, other relevant movement disorders, often recovered after stopping the drug. Sleep disorders (insomnia, drowsiness). Notify your doctor any unwanted effects related to medication.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Dozidine MR 35 mg is contraindicated in the following cases:

Hypersensitivity to trimetazidin or excipient ingredients in the formula of the product.

Be cautious when using

trimetazidin can cause or worsen Parkinson's symptoms (Run, slow exercise and difficulty, increase muscle tone), so patients, especially elderly patients need regular checks and monitoring.

In suspected cases, patients need to be taken to neurologists for appropriate examination. When encountering movement disorders such as Parkinson's symptoms, vacuum syndrome, tremor, unstable gait, it is necessary to immediately stop using trimetazidin. These cases occur and often recover after stopping the drug.

Most patients recover after stopping the drug about 4 months. If Parkinson's symptoms continue to happen for more than 4 months after the drug is stopped, consulting neurologists. Selfs may be encountered, unsteady gait, or lowering blood pressure, especially in patients who are taking medications for hypertension (see more unwanted effects).

Be careful when prescribing trimetazidin for patients with high sensitivity levels such as (see more dosage and usage): Patients with average renal impairment, patients over 75 years old.

The ability to drive and operate machinery

trimetazidin can cause symptoms such as dizziness and drowsiness, so it can affect the ability to drive and operate machinery.

Pregnancy

The results of animal research have not been confirmed for sure whether or not the teratical effect of trimetazidin. There is not enough clinical evidence to eliminate the risk of fetal defects. It is best not to use trimetazidin during pregnancy.

Breastfeeding period

There is no evidence of the presence of trimetazidin in breast milk, so the best choice is not to breastfeed during trimetazidin treatment.

Interactive drug

There has been no interaction with any drug.

Trimetazidin is not an induction drug nor is not a drug that inhibits the liver metabolic enzyme in the liver and thus is more likely to trimetazidin does not interact with many metabolic drugs in the liver. Anyway, you still need to be careful to monitor when coordinating with another drug.

Storage

In a dry place, temperatures below 30 ° C, avoid light.

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