Drosperin Abbott daily contraceptive pills (1 blister x 28 tablets)

Dosage form Box of 1 blister x 28 tablets
Specifications Drospirenone, Ethynyl Estradiol
Ingredient Abbott

Ingredient

Composition information	Content
Drospirenone	3mg
Ethynyl Estradiol	0.03mg

Uses

Indications

The drug is prescribed in the case of contraception.

Pharmacokic

The combination of estrogen (Ethinyl estradiol) and Drospirenone has the effect of inhibiting Gonadotropin. Although the main mechanism of this activity is to prevent ovulation, other changes also occur, including changes in cervical mucus (increasing difficulties when sperm into the uterus) and changes in the uterus (reducing the ability to nest).

Pre -clinical studies on animals and in vitro shows that Drospirenone has no effects of an Androgenic, estrogenic, glucocorticoid, and glucocorticoid resistance. Pre -clinical studies on animals also show that Drospirenone has anti -androgenic effects.

pharmacokinetic

The absorption of absorption of Drospirenone is 76%. The absorption bioavailability of Ethinyl estradiol is nearly 40%, the maximum concentration in the plasma of Drospirenone and Ethinyl Estradiol is about 1-3 hours after drinking.

The excretion of Drospirenone's excretion is almost completely after 10 days of drinking and the amount of excretion in the feces is higher than in the urine. Drospirenone is almost completely metabolized, and only a small amount of non -metabolic drugs are excreted in urine and feces. At least 20 metabolites are seen in urine and feces.

Nearly 38 - 47% of metabolites in urine are glucoronic and sulfate complexes. In feces, nearly 17-20% of metabolites are excreted in the form of glucoronic and sulfate. Ethinyl estradiol is excreted in urine and stool in the form of glucoronic and sulfate complex.

Before taking Drosperin Abbott daily contraceptive pills (1 blister x 28 tablets)

How to use

Take the tablet with a glass of water.

Dosage

Take 1 capsule a day, at the same time for every day, 28 consecutive days in the order only on plastic containers containing drugs. The first beige tablet (clearly stated on the order number on the plastic container) must be taken on the first day of menstruation (menstruation) of the menstrual cycle.

The order of pills is very important, always taking beige tablets (active pills), when all of these tablets, new white tablets (inactive pill). Always hold another blister to make sure you will not be delayed in the first cycle.

What to do when using overdose?

What to do when forgetting the dose? In case of forgetting to drink, must follow the instructions of the doctor, pharmacist or according to the following general recommendations:
If you forget an active tablet: Take it as soon as you remember, even if you take 2 capsules in the same day, and then take the next tablets next to normal schedule. Using an extra method of contraception without hormonal or mechanical contraception (condoms, vaginal barriers) in the next 7 days, in addition to continuing to use Drosperin tablets as normal schedules.
If you forget to take 2 consecutive tablets in the first week or the second week: take 2 capsules a day for 2 consecutive days, at the normal time. Then take the next tablets as the normal schedule 1 tablet daily. In this case, the risk of ovulation increases, so you should use other methods of contraception without hormonal or mechanical contraception (condoms, vaginal barriers) for the next 7 days, in addition to continuing to use the remaining Drosperin tablets as usual.
If you forget to take 2 consecutive activities in the third week, or if you forget to take over 3 consecutive activity within the first 3 weeks: remove the remaining tablets of the blister and start with the first tablet of a new drug blister right on the next day. You should use additional methods of other non -hormonal contraception or mechanical contraception (condoms, vaginal barriers) within 7 days after forgetting to take the pill. It is likely that you will not have a period in that month, but if you do not have menstruation for 2 consecutive months, see a doctor to determine whether or not you are pregnant.
Mistakes while taking inactive tablets (white tablets) can be ignored. But the first active (beige) tablet in the next drug must be taken on the appropriate day as scheduled.

Side Effects

When using the drug, you may experience unwanted effects (ADR).

If you see the following side effects need a doctor:

Stomach pain or abdominal pain; cough out blood; severe headache; Disorders of coordination suddenly, loss or visual change; Chest pain, groin or leg (especially in the ankles).

Difficulty breathing; Fatigue, numbness or pain in the arm or leg.

Especially in the first 3 months of taking birth control pills:

Change the way of menstruation or bleeding in the middle of the menstrual cycle, reduce blood in the cycle, vaginal bleeding between normal cycles, prolonged menstrual periods, completely loss of menstruation for months or occasional loss of menstruation in non -consecutive months. depression; Swelling or pain with pain when crushing or touching the upper abdomen; Stomach pain, hip pain or abdominal pain, jaundice and eyes, especially in women who smoke, mammary gland tumors, on people who have breast disease.

Swelling, pain and increased sensitivity to pain when crushing or touching the chest; dizzy; Nausea, swelling of the ankles and feet. Increase or decrease sexual desire, increase skin sensitivity to light.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Contraindications in the following cases:

Not used in cases of vascular disease, blood circulation problems, blood clotting changes.

thrombosis; cardiovascular disease; cerebral hemorrhage; Breast cancer, cervical cancer, endometrium, uterus, or other cancers related to endocrine. History of jaundice during pregnancy, or while using previous oral contraceptives (jaundice and eyes).

Kidney disease; adrenal gland disease; Abnormal vaginal bleeding for unknown causes; Pregnant has been diagnosed or suspected.

Caution when using

Use another contraceptive method for at least the first 7 days of the first cycle to use the drug. Doctors also want to recommend another method of contraception in the first 3 weeks of the first cycle to use the drug to ensure better contraception.

Use another method of contraception in case of forgetting to take several doses (see the "dose and use" part), or are taking other drugs that reduce the effectiveness of birth control pills.

In case of vomiting or diarrhea, another method of contraception should be used without hormonal, right when taking the drug or a short time after starting.

notify the doctor if you are pregnant or breastfeeding. In case of being diagnosed with pregnancy or suspicion of pregnancy, you should stop the medicine and consult a doctor.

This drug is not recommended to be used during breastfeeding, because the hormones in the contraceptive pills are excreted through breast milk, which can cause side effects to the fetus. Notify the doctor in case you are late, to determine the cause clear, either pregnant or other causes.

Avoid smoking when taking hormonal contraceptives because tobacco increases the risk of serious side effects, especially if in people over 35 years old. Avoid going out for a long time, because in some people who increase light sensitivity.

The use of non -protective oral contraceptives against HIV/AIDS and other sexually transmitted diseases.

Notify your doctor if you have an allergic reaction to Drospirenone, Ethinyl Estradiol, with other hormones or any other drugs, other substances (food, dyes, preservatives, ...). Notify the doctor or dentist about using the drug, before going through any surgery (including tooth surgery) or any emergency treatment.

In some women may have symptoms of gums sensitive, swollen or mild bleeding, notify the dentist. Regular brushing can reduce this effect. If taking pills causes nausea or discomfort, then take the medicine at meals.

notify the doctor in the case of abnormal vaginal bleeding, or prolonged or repeated, to eliminate the causes of malignant pathology; Before doing tests; If you use contact lenses and you notice that there are visual or uncomfortable changes in the eye; History of the disease or are suffering from the following diseases: Family history of breast cancer and healing mammary glands, biliary tract diseases (especially gallstones), epilepsy, depression, migraine, high blood cholesterol, high blood pressure, high potassium, menstrual problems, tobacco addiction and cases stated in the "contraindication" section. Examine doctor periodically to control the treatment process.

Pregnancy and nursing mothers

notify the doctor if you are pregnant or nursing. In case of being diagnosed with pregnancy or suspicion of pregnancy, you should stop the medicine and consult a doctor.

This drug is not recommended for use during breastfeeding, because the hormones in the contraceptive pills are excreted through breast milk, which can cause side effects to the fetus.

notify the doctor in case you are late, to determine the cause clear, either pregnant or other causes.

Medicinal interaction

Interactive has been described with drugs that increase blood potassium, nonsteroidal anti -inflammatory anti -inflammatory (such as ibuprofen, naproxen, ketoprofen); Potassium diuretics (such as spironolacton, triamteren, amilorid); potassium supplements; Salt substances; Inhibition of enzyme (such as captopril, benazepril, lisinopril, enalapril); Angiotensin II receptor antagonists (such as Candesartan, Losartan, Valsartan, Telmisartan); heparin.

Interactions can also occur with antibiotics (such as ampicillin, tetracyclin); Barbiturat (such as phenobarbital); phenytoin; Carbamazepin; Griseofulvin, Primidon; Rifampin; phenylbutazon; warfarin; hydrocortison; Prednisolon; cyclosporin; Clofibrat; Theophylin; morphine; Salicylic acid; Temazepam; Atorvastatin; acetaminophen; Ascorbic acid; Measles (St. John’s Worth).

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children.

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