Drotusc Forte Medisun Treatment of stomach spasms, intestinal syndrome is irritated (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Drotaverin
Ingredient Me Di Sun Pharmaceutical Joint Stock Company - Vietnam

Ingredient

Composition information	Content
Drotaverin	80mg

Uses

indicated

stomach spasms. Irritated bowel syndrome. Learning

Drotaverin hydrochloride is synthetic isoquinolein. Has anti -spasms on smooth muscle not belonging to the cholin group. The mechanism of impact of the drug is due to the inhibition of phosphodiesterase enzymes (PDE) IV and increases the Camp level, leading to smooth muscle relaxation through the inactivity of the kinase of the mild Myosin chain (MLCK).

Drotaverin inhibits PDE IV in vitro, but does not inhibit ISOENZYM PDE II and PDE V. PDE IV plays an important role in the sealing of smooth muscles; Based on the selective inhibition PDE IV can be applied in the treatment of hyperactivity disorders and diseases with smooth spasm of the digestive tract.

The drug is effective for all cases of plain muscle spasms of nerve and muscle origin.

has anti -muscle spasms similar to Papaverin but stronger, appears earlier and is less toxic.

pharmacokinetics

absorption:

The oral absorption is completely equivalent to the injection.

Distribution:

Drotaverin has a high cohesion rate with protein (25-98%), especially with albumin, gama and beta-globulin. Drotaverin can cross the placenta.

Peak of plasma peaks reached about 45 to 60 minutes after drinking and after the first metabolism, 65% of the oral dose was found in the form of unchanged in the circulatory system.

Metabolism:

Drotaverin is metabolized in the liver. Biological destruction time is 8-10 hours.

Era:

In fact, the drug disappears completely in the body after 72 hours. More than 50% of the drug is excreted in the urine and about 30% in feces. The drug is excreted mainly in the form of main metabolism; No form not found in urine.

Before taking Drotusc Forte Medisun Treatment of stomach spasms, intestinal syndrome is irritated (10 blisters x 10 tablets)

How to use

This drug is only used by a doctor, drinking several times a day.

Dosage

Average dose:

Adults: 1-3 tablets/day, 1 tablet each time. Or according to the doctor's instructions.

What to do when overdose?

Handling: Symptom support.

What to do when you forget a dose?

Side Effects

Rare:

flushed, fast heartbeat, mild hypertension.

Hypersensitivity, chronic hepatitis.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

sensitive to one of the ingredients of the drug.

Hepatic failure, renal failure, severe heart failure.

Caution when using

Porphyrin metabolism disorders.

Pregnant and lactating women.

The effect of the drug on the ability to drive and operate machinery

The drug does not affect, but need the kidney in this case when there are unwanted effects when taking the drug.

Using drugs for women during pregnancy and lactation

Pregnancy:

Experimental studies do not see teratogenic drugs. However, like the majority of other drugs, to be cautious, avoid using Drotaverin hydrochloride for prolonged pregnancy, only used when necessary according to the instructions of the physician.

Breastfeeding period:

When used for women who are breastfeeding should not take the drug for a long time, only used when necessary according to the instructions of the physician.

Interactive drugs

The central nervous system inhibitors increases the effects of drugs and morphine has the effect of copper with the drug.

When using simultaneously, the drug interferes with Levodopa's treatment effect in Parkinson's patient, so avoid using these two drugs when treating Parkinson's patient.

When using simultaneously with muscle relaxants, drugs increase the effect of treatment.

Storage

In the dry place, temperatures below 30 ° C.

Other drugs

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