Dry syrup mixed with Azismile 5.01G Kolmar for infection treatment (15ml)

Dosage form Box x 15ml
Specifications Azithromycin

Ingredient

Thành phần cho 15ml

Composition information	Content
Azithromycin	5.01g

Uses

Indications

Azismile dry syrup 5.01 g Kolmar 13 g (15 ml) is indicated for use in cases of bacterial infections caused by azithromycin sensitive bacteria such as:

Sinusitis caused by acute bacteria.

Acute otitis media.

Sore throat, tonsillitis.

Chronic bronchitis.

Mild to medium -sized pneumonia pneumonia.

Skin infections and soft tissue.

Urethritis is uncomplicated caused by chlamydia trachomatis and cervicitis.

Pharmacy

azithromycin is a broad -spectrum antibiotic in the macrolid group, called azalid. The drug has a strong bactericidal effect by attaching to ribosom of pathogenic bacteria, preventing their protein synthesis. However, the drug has been crossed with erythromycin, so be careful when using azithromycin.

Azithromycin works on gram -positive bacteria such as streptococcus, pneumococcus, staphylococcus aureus. Studies conducted in Vietnam show that these species are about 40%resistant to macrolid group, affecting the ability to use azithromycin. Some other bacteria strains are also sensitive to azithromycin such as: Corynebacterium diphtheriae, Clostridium perfringens, peptostreptococcus and propionibacterium acnes.

Erythromycin resistant bacteria can also be resistant to azithromycin as gram -positive strains, including Enterococcus species and most staphylococcus strains of methicillin resistant to azithromycin.

Azithromycin works on Gram -negative bacteria such as: Haemophilus influenzae, Haemophilus parainfluenzae, and Haemophilus ducreyi, Moraxella Catatrhalis, Acinetobacter, Yersinia, Legionella Pneumophila, Bordetella Pertussiss, and and and and and Parapertussis; Neisseria gonorrhoeae and campylobacter sp. In addition, this antibiotic is also effective with Listeria Monocytogenes, Mycobacterium Avium, Mycoplasma Pneumoniae and Hominis, Ureaplasma Urealyticum, Toxoplasma Gondii, Chlamydia Trachomatis and Pneumoniae, Treponema Pallidum, Borrelia BurgdoriiIs.

Azithromycin has a moderate effect on other Gram -negative bacteria such as E.coli, Salmonella Enteritidis and Salmonella Typhi, Entobacter, Aeromonas Hydrophila, Klebsella. The Gram -negative strains are anti -Azithromycin, Proteus, Serratia, Pseudomonas Aeruginosa, Morganella.

azithromycin acts on weak gram -positive bacteria than erythromycin, but the effect on Gram -negative bacteria is stronger, including Haemophilus.

Resistance mechanism: Azithromycin resistance occurs naturally or collected. There are three mechanisms of resistance in bacteria: changing the effect, changing antibiotic transport channel and antibiotic transformation. Azithromycin is crossed with some resistance Gram -positive bacteria of cultured.

Sensitivity to macrolid decreases over time, this is especially recorded in Streptococcus Pneumoniae and Staphylococcus aureus. Similarly, Streptococcus Viridans and Streptococcus Agalactiae (Streptococcus Group B) are less sensitive to other macrolids and Lincosamid.

Dynamic pharmacokinetics

After drinking, azithromycin is widely distributed in the body, bioavailability is about 40%. Food reduces Azithromycin absorption by about 50%. After taking the drug, the plasma peak concentration is reached within 2 to 3 hours.

The drug is distributed mainly in tissues such as lungs, tonsils, prostate glands, granulocytes and macrophages ..., higher in the blood (about 50% of the maximum concentration found in plasma). However, the concentration of the drug in the nervous system is very low.

Azithromycin is small, methyl is reduced in the liver, and is eliminated through bile in the formless form and partly in the form of metabolism. About 6% of oral doses except for urine within 72 hours in the form of unchanged. The sale time is 2 - 4 days.

Before taking Dry syrup mixed with Azismile 5.01G Kolmar for infection treatment (15ml)

How to use

oral drugs, can be used with food.

Dosage

Azismile dry syrup 5.01 g Kolmar 13 g (15 ml) should use a single dose of the day.

Children> 45 kg and adults (including the elderly): The total dose of azithromycin is 1500 mg for 3 days (500 mg x once daily).

For non -complications of genital transmission due to Chlamydia trachomatis: The dose is 1000 mg, only 1 time orally.

For sensitive Neisseria Gonorrhoeae, the recommended dose is 1000 mg or 2000 mg Azithromycin combined with 250 mg or 500 mg Ceftriaxon based on the treatment guide of each country.

In case the patient is allergic to penicillin and/or cephalosporin, it is necessary to refer to the treatment guide of each country.

Children

Children weigh no more than 15 kg (under 3 years old): The most accurate dose possible by syringe 10 ml. The syringe has the smallest separation of 0.25 ml, allowing 10 mg Azithromycin to correspond to each level.

Children weigh more than 15 kg: Dose of drugs with a spoon (5 ml capacity) in the following way:

15 - 25 kg (3 - 7 years old): 5 ml (200 mg) x 1 time daily for 3 days.

26 - 35 kg (8 - 11 years old): 7.5 ml (300 mg) x 1 time daily for 3 days.

36 - 45 kg (12 - 14 years old): 10 ml (400 mg) x 1 time daily for 3 days.

45 kg: Dosage like adults.

No dose adjustment for patients with mild to medium to medium renal failure (GFR 10 - 80 ml/minute). Be careful when using azithromycin for patients with severe renal impairment (GFR

Patients with liver failure

Because azithromycin is metabolized in the liver and eliminated through bile, it is not advisable to use medication for patients with serious liver disease. There is no research on the use of drugs for these subjects.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms of overdose

There is no full document. The typical symptom of macrolid antibiotic overdose is to reduce hearing, nausea, vomiting and diarrhea.

Handling

Gastric lavage, supportive treatment.

Actively monitor for timely management measures.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Azismile 5.01 G Kolmar dry syrup (15 ml), you may experience unwanted effects (ADR).

Like erythromycin, azithromycin is a good tolerated drug and low unwanted effect rate (about 13% of patients). The most common is digestive disorders (about 10%) with symptoms of nausea, abdominal pain, abdominal spasms, vomiting, flatulence, diarrhea, but often mild and less occur than when using erythromycin. It can be seen that the transient change in the number of neutrophils or temporary increase in the liver enzyme, sometimes there may be rash, headache and dizziness.

Hearing effects: long -term use in high doses, azithromycin can reduce recovery in some patients.

Common, ADR> 1/1000

Digestive: vomiting, diarrhea, abdominal pain, nausea.

Uncommon, 1/100> ADR> 1/1000

Body: Fatigue, headache, dizziness, sleeping.

digestive: flatulence, indigestion, no appetite. skin: rash, itching. other effects: Vaginitis, cervix.

Rare: ADR

Body: Anaphylaxis.

Skin: Evaluation.

Liver: enzyme transaminase increases.

blood: Mild and temporary neutropenia.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Azismile dry syrup 5.01 g Kolmar 13 g (15 ml) Contraindicated in cases of hypersensitivity to azithromycin or any antibiotic belonging to the MacRolid group or any ingredient of the drug.

Be cautious when using

be cautious when using azithromycin as well as other macrolids because of the ability to cause allergies such as nerveemia and anaphylactic reaction, but very dangerous but very dangerous. Azithromycin is metabolized in the liver, should be used carefully in patients with severe liver disease.

may be life -threatening if used in patients with hepatitis. When used with the same poison with the liver can cause liver disease. If there is symptom of liver dysfunction such as jaundice, dark urine, increased bleeding or cerebral liver disease, it is necessary to immediately conduct liver function tests. Stop using azithromycin if liver dysfunction appears.

There is no research data when using azithromycin and drugs containing Ergot's derivatives. However, the theory has precipitated when using Ergot along with macrolid antibiotic group, so do not simultaneously use azithromycin and drugs containing Ergot's derivatives.

Like any antibiotic preparation, it is necessary to observe the signs of infection with other microorganisms, including fungi.

diarrhea caused by Clostridium Difficile (CDAD) has been reported with the use of almost all antibiotics, including azithromycin, and the degree of mild diarrhea to death colitis. CDAD must be considered in all patients with diarrhea after antibiotics. The CDAD report has occurred more than two months after using antibacterial agents, so it is necessary to closely monitor patients after the medication period.

In patients with severe renal impairment (GFR

extends the QT range, causing risk of arrhythmia, cardiac arrest has been reported when using a macrolid group, including azithromycin. Therefore, it is necessary to be cautious when used in patients with continuous arrhythmia (especially women and the elderly) such as:

There is a long QT range.

Using substances that can extend the QT interval such as anti -arrhythmia IA (Quinidin and Procainamid) and group III (Dofetilid, Amiodaron and Sotalol), Cisaprid and Terfenadin; Anti -psychotic drugs such as pimozid; Antidepressants such as citalopram and fluoroquinolon such as moxifloxacin and levofloxacin.

There is electrolyte disorder, especially in the case of hypokalemia and hypokalemia.

Slow heart rate, arrhythmia or severe heart failure.

There has been a report of myasthenia gravis when using azithromycin.

It is necessary to consider the following before prescribing azithromycin:

azithromycin powdered powder is not suitable for severe infection treatment, due to the need for high antibiotic concentration in the blood.

azithromycin is not the first option when treated by experience for infections in the region with a resistance rate of 10% or more.

In areas with high ratio of Erythromycin, it is necessary to consider the progression of azithromycin sensitive model and other antibiotics.

There was a streptococcus pneumoniae (30%) report when using azithromycin in some European countries. Attention should be paid to the treatment of streptococcus pneumoniae.

Sucrose drugs should be cautious for patients with diabetes and have rare genetic problems such as fructose intolerance, galactose with poor absorbent glucose or deficiency of isomaltase.

It is necessary to adjust the appropriate dose for people with renal disease with creatinine clearance coefficient less than 40 ml/min.

The drug contains sodium, so it should be cautious when used for people with sodium abstinence.

The ability to drive and operate machinery

The drug can cause unwanted effects such as headache, dizziness, sleeping, and can affect the ability to drive and operate machinery.

Pregnancy

There is no research data on pregnancy. Azithromycin should only be used when there are no other appropriate drugs

The period of breastfeeding

There is no data to study the excretion ability of azithromycin by breast milk. Only use azithromycin when there are no other appropriate drugs.

Drug interaction

Food reduces the ability to absorb drugs by up to 50%. Therefore, the drug should be used for 1 hour before eating or 2 hours after eating.

Conducting chicken fungus: Do not use azithromycin simultaneously with chicken spurs derivatives because of the potential to cause poisoning.

Antacids: When needed, azithromycin must be used 1 hour or 2 hours after using antacids.

Cyclosporin: Some antibiotics of macrolid group interfere with cyclosporin metabolism. Therefore, it is necessary to monitor the concentration and adjust the dose of cyclosporin accordingly.

Digoxin: For some patients, Azithromycin can affect digoxin metabolism in the intestine. Therefore, when using these two drugs, it is necessary to monitor the concentration of digoxin because it is likely to increase digoxin levels.

Theophylin: There has not been any effect on pharmacokinetics when two drugs azithromycin and theophylin are used simultaneously on healthy volunteers, but in general, theoophylin concentration should be monitored when used simultaneously with this drug with azithromycin.

Warfarin: When studying pharmacokinetics on healthy volunteers using a single dose of 15 mg of warfarin, azithromycin does not affect anticoagulant effects. These 2 drugs can be used at the same time, but still need to monitor the patient's blood clotting time.

Cetirizin: When using simultaneously azithromycin with cetirizin, there is no pharmacokinetic interaction and has no significant change in the QT range.

Didanosin: Concomitance azithromycin 1200 mg/day with didanosin 400 mg/day in 6 HIV objects positive does not affect the dynamics of Midanosin compared to placebo.

Zidovudin: The dose of 1000 mg/1200 mg/600 mg azithromycin has little effect on Zidovudin pharmacokinetics or its glucuronic metabolites. However, using azithromycin increases the concentration of zidovudin phosphorylation, metabolites with clinical activity in peripheral blood. Although it is not clinically significant, but benefits for patients.

Atorvastatin: simultaneously use Atorvastatin (10 mg daily) and azithromycin (500 mg daily) does not change the concentration of Atorvastatin in plasma. However, there was a report on the pattern after taking azithromycin with statin.

Carbamazepin: There is no pharmacokinetic interaction when using simultaneously azithromycin and carbamazepin.

cimetidine: There is no pharmacokinetic interaction when using simultaneously azithromycin and cimetidin.

Oral anticoagulant (Coumarin): Pay attention to the frequency of monitoring of prothrombin when taking azithromycin and COUMARIN anticoagulant.

Efavirenz: There is no pharmacokinetic interaction when using simultaneously Azithromycin and Efavirenz.

Fluconazole: Using 1200 mg of azithromycin does not change the pharmacokinetics of a dose of Fluconazole 800 mg but has a reduced CMAX concentration (18%) of azithromycin.

indinavir: No pharmacokinetic interaction has been reported when used simultaneously azithromycin and indinavir.

methylprednisolon: azithromycin does not affect the pharmacokinetics of methylprednisolon when shared.

Midazolam: When using simultaneously azithromycin with midazolam, azithromycin does not affect the pharmacokinetics of Midazolam.

Nelfinavir: Concomitance azithromycin and nelfinavir increases the levels of azithromycin but has no clinical desire effect, so there is no dose adjustment.

Rifabutin: There has been a neutropenia report in patients with treatment of azithromycin and rifabutin simultaneously.

Sildenafil: There is no pharmacokinetic interaction that is reported when used simultaneously Azithromycin and Sildenafil.

terfenadin: There is no full reporting with an interaction between azithromycin and terfenadin. Theophylin has no evidence of clinical pharmacokinetic interaction when using simultaneously azithromycin and theophyllin.

triazolam: There is no pharmacokinetic interaction that is reported when used simultaneously azithromycin and triazolam.

trimethoprim/sulfamethoxazol: There is no effect when using azithromycin with trimethoprim/sulfamethoxazol.

The drugs extend the QT interval: Do not use azithromycin simultaneously with drugs that extend the QT.

Storage

Storage in closed packaging, dry place, avoid light, temperature below 30 ° C.

The oral fluid after phase can be stored within 5 days at temperatures 2 - 8 ° C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.