Dutixim 100 US Pharma powder for infection (14 packs)

Dosage form 14 package box
Specifications Cefpodoxime
Ingredient USP

Ingredient

Composition information	Content
Cefpodoxime	100mg

Uses

Indications

Dutixim 100 drugs are indicated in the following cases:

dutixim is used in the form of oral to treat mild to moderate diseases in the lower respiratory tract, including acute pneumonia is starred in the community due to the Sfrepfococcus factoriae or Haemophilus Influenzae sensitive (including the birth strains Beta - Lactamase), the acute phase of the sensitive S. Pneumiae strains and by H. H. H. strains Influensae or Moraxella (Branhamella, formerly known as Neisseria) CatVrhalis, did not produce beta - lactamase. Penicillin main treatment. Cefpodoxim also plays a role in the treatment of acute otitis media caused by sensitive strains of S. Pneumoniae, H. Influenzae (including beta - lactamase) or B. CatVrhalis. Pneumoniae, Proteus Mirabilis, or Staphylococcus saprophyticus.

In countries with low antibiotic resistance ratio, Cefpodoxim has a high sustainability of the attack of beta - lactamase, created by Gram -negative and Gram -positive bacteria. In principle, Cefpodoxim has a activity for Gram -positive bacteria such as pneumococcus (Streptococcus pneumoniae), streptococcus streptococcus (streptococcus) group A, B, C, G and with staphylococcus aureus, S. Epidermidis C6 or not producing beta - lactamase. However, the drug has no anti -staphylococcus effects against isoxazoly - penicillin due to changes in penicillin -mounted protein (resistant to methicilin staphylococcus aureus MRSA). This MRSA antibiotic resistance is growing in Vietnam.

dutixim also works for Gram -negative bacteria, Gram -positive and gram -negative bacilli. The drug has anti -anti -negative bacteria that are important, such as E. Coli, Klebsiella, Proteus Mirabilis and Citrobacter. However, in Vietnam, these bacteria are also resistant to cephalosporin 3rd generation. This issue should be noted because it is a risk of failure in treatment.

pharmacokinetics

dutixim is the form of cefpodoxim proxetil oral drug (ester of cefpodoxim). Cefpodoxim Proxetil has little antibacterial effect when not hydrolyzed into cefpodoxim in the body. Cefpodoxim Proxetil is absorbed through the gastrointestinal tract and is metabolized by non -specific esters, maybe in the intestinal wall, the metabolic cefpodoxim metabolites work.

Biology of Cefpodoxim is about 50%. This biological use increases when using Cefpodoxim with food. The half -life of Cefpodoxim is 2.1 - 2.8 hours for patients with normal kidney function. Half of the serum increases to 3.5 - 9.8 GID in people with kidney disabled.

After taking a dose of Cefpodoxim, in healthy adults with normal kidney function, plasma peak concentration is reached within 2-3 hours and has an average value of 1.4 micrograms/ml, 2.3 micrograms/ml, 3.9 micrograms/ml for doses of 100 mg, 200 mg, 400 mg.

about 40% Cefpodoxim binds to plasma proteins.

The drug is eliminated in the form of non -change through the filter of the glomerular and excretion of the renal tubules. About 29 - 38% of the dose is eliminated within 12 hours in adults with normal kidney function. There is no biological change in the kidneys and liver. The drug is eliminated to a certain extent when the hemorrhage.

Before taking Dutixim 100 US Pharma powder for infection (14 packs)

How to use

Oral drugs.

cefpodoxime proxetil should be indicated with food. In patients with renal failure (creatinine clearance below 30ml/minute), the distance between the dose should be increased by 24 hours.

No need to adjust the dose in cirrhosis patients.

Dosage

Adults

Upper respiratory infections, including tonsillitis and sore throat: 100mg every 12 hours in 10 days.

Acute pneumonia is suffering from the community: 200mg every 12 hours in 14 days.

Gonorrhea infection with no complications: The only dose 200mg.

Urinary tract infections have no complications: 100mg every 12 hours in 7 days.

Skin infection and skin structure: 400mg every 12 hours in 7-14 days.

Children

Treatment of acute otitis media in children from 5 months - 12 years old: Topic 5 mg/kg (maximum 200 mg) Cefpodoxim every 12 hours, or 10 mg/kg (maximum 400 mg) once a day, for 10 days.

Treatment of bronchitis/tonsillitis is mild and medium in children 5 months - 12 years old: Using the common dose is 5 mg/kg (maximum 100 mg) every 12 hours, for 5-10 days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Symptoms due to overdose may include nausea, vomiting, epigastric pain and diarrhea. In case of severe poisoning reactions due to overdose, hemolysis or peritoneal fertilizer may help remove Cefpodoxime from the body, especially when the kidney function is impaired.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting a dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Dutixim 100, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: Nausea, vomiting, diarrhea, abdominal pain

Allergic reactions: Reaction such as serum with rash, fever and joint pain and anaphylactic reaction.

Blood: Eosinemia, blood disorders. Time.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Dutixim 100 contraindications in the following cases:

Do not use cefpodoxim for people who are allergic to cephalosporin and people with porphyrin metabolism disorders.

Other cases are specified in the drug or prescription manual. Dutixim 100 contraindications must be understood as absolute contraindications, which is not for some reason that the flexible recontraction case is used.

Be cautious when using

It is necessary to think of fake colitis in patients with diarrhea after taking Cefpodoxime Proxetil. It is necessary to be especially careful in patients who have responded to anaphylaxis for penicillin. Cefpodoxime proxetil should not be appointed for patients with a history of cephalosporin sensitivity or other beta-lactam. Allergic reactions are easy to occur in patients with a history of allergies.

The subjects should be noted before taking Dutixim 100: The elderly, pregnant women, nursing women, children under 15 years old, people with liver failure, kidney failure, people who are allergic to any substance in the ingredients of the drug ... or the object of myastheniah, liver coma, gastric ulcer.

The ability to drive and operate machinery

There has been no report on the effect of drugs when used for drivers and machinery operation.

Pregnancy and nursing mothers

Pregnancy

There is no document that mentions the use of Cefpodoxim during pregnancy. However, cephalosporins are often considered safe when used for pregnant women.

Breastfeeding period

cefpodoxim is secreted in breast milk with low concentrations. Despite low concentrations, there are still 3 problems that will occur for breastfed children with cefpodoxim: Disorders of intestinal bacteria, direct effects on the body late and bacterial culture results will be wrong, if antibiotic when fever.

Drug interaction

plasma concentrations decreased by about 30% when Cefpodoxime Proxetil is indicated with antacids or H2 inhibitors. When indicating Cefpodoxime Proxetil simultaneously, the compound is known to be kidney toxicity, so the kidney function should be closely monitored. Cefpodoxime concentration in plasma increases when indicating cefpodoxime proxetil with probenecid.

Change of testing values: Cephalosporins makes the Coomb test directly positive.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

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