East dried powder mixed with omevin vinphaco treatment for gastroesophageal reflux - esophagus (10 vials x 10 ml)

Dosage form Box of 10 vials
Specifications Omeprazol

Ingredient

Composition information	Content
Omeprazol	40mg

Uses

Indications

Omevin drugs are indicated in the following cases:

Treatment of gastroesophageal reflux. Adenosin Triphosphatase (H+/K+ ATPASE) is also known as the proton pump in the cell wall of the stomach. Fast effect, prolonged but recovered. Omeprazol does not work on receptor (receptor) acetylcholine or histamine receptor. The maximum effect is achieved after 4 days of treatment. In patients with duodenal ulcer, it is possible to maintain a 80% reduction in gastric acid in 24 hours.

pharmacokinetic pharmacokinetics

Distribution

The drug is attached to about 95% to plasma proteins. Although Omeprazol has a short selling time, the drug has a long -lasting effect (due to the prolonged attachment of the drug to H+/K+ ATPASE). Therefore, it is possible to use the drug once a day.

Metabolism

Omeprazol is almost completely metabolized in the liver, mainly thanks to the cytocrom P450 isoenzyme to become hydroxy omeprazol and a small part metabolized through CYP3A4 to form omeprazol sulfon.

Elimination

The metabolites are not active and are excreted mainly in urine and partially in the feces.

The pharmacokinetics of the drug are not significantly changed in the elderly or people with kidney function. In people with liver function failure, the area under the increased curve and the clearance of drugs decreases, but there is no drug accumulation and the metabolites of the drug in the body.

Before taking East dried powder mixed with omevin vinphaco treatment for gastroesophageal reflux - esophagus (10 vials x 10 ml)

How to use

drugs used intravenously or intravenously.

Suction 10 ml of distilled water mixed in a bottle jar, shake until the powder is completely dissolved.

For intravenous solution, dilute the drug in 100 ml of 0.9%sodium chloride solution.

Note: The drug after mixing in the solvent is preserved for up to 24 hours under normal conditions.

Dosage

In case of oral can not be used, omeprazol is intravenously slowed for at least 3 minutes, the dose is equivalent to 40 mg of omeprazol/time/day or intravenous transmission for 20 to 30 minutes, equivalent to 40 mg omeprazol/time/day.

Patients with Zollinger - Ellison syndrome have also been intravenously at higher doses than conventional doses.

For children:

Can be intravenously 500 micrograms/kg to up to every 20 mg in children from 1 month to 12 years old and can increase to 2 mg/kg to up to 40 mg once a day.

In the elderly:

No dose adjustment.

In people with kidney failure:

Birth changes is not significant, no dose adjustment.

In people with liver failure:

The area below the increased curve and the elimination of the drug slowed down. Use 20 mg/time/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

In literature, there are notice of 2 cases of overdose Omeprazol. Clinical manifestations are mainly drowsiness, headache (probably due to metabolic) and fast heartbeat. Both patients recovered, had no events nor had any special treatment.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting a dose?

Side Effects

When using omevin, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Systemic: headache, drowsiness, dizziness.

digestive: diarrhea, nausea, vomiting, abdominal pain, constipation, abdominal distention.

Uncommon, 1/1000

Neurological: insomnia, sensory disorders, dizziness, fatigue.

skin: urticaria, itching, rash.

Liver: Increase transaminase temporary.

Rare, ADR

Systemic: sweating, peripheral edema, hypersensitivity including veins, anaphylaxis.

Hematology: leukopenia, thrombocytopenia, all blood cells, peripheral, granulocytes, autoimmune hemolytic anemia. nerve: Confusion has recovery, agitation, depression, hallucinations in elderly patients and especially in serious patients, hearing disorders.

Endocrine: Big breasts in men.

digestive: gastritis, candidiasis infection, dry mouth. liver: hepatitis, jaundice or no jaundice, brainstorming in people with liver failure. Respiratory: Bronchospasm.

muscle - bone: joint pain, muscle pain.

urinary - sex: interstitial nephritis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Omevin drugs are contraindicated in the following cases:

Hypersensitivity to omeprazol or any ingredients of the drug.

Precautions when using

Before giving people with stomach ulcers using omeprazol, it is necessary to eliminate the possibility of malignant tumors (the drug can cover symptoms, so it is a late diagnosis).

Using proton pump inhibitors may increase the risk of gastrointestinal infections (for example, Salmonella, Campylobacter infection).

The ability to drive and operate machinery

The drug can cause headaches, dizziness, insomnia, fatigue.

Do not drive or operate machines when experiencing unwanted effects of the drug.

Pregnancy

Although experiments do not see omeprazol that is likely to cause deformities and toxic to the fetus, but should not be used for pregnant people, especially in the first 3 months.

Breastfeeding period

Do not use omeprazol in nursing mothers. So far, no research documents have concluded on this issue.

Drug interaction

Omeprazole does not have an important interaction on clinically when used with amoxicillin, bacampicilin, caffeine, lidocaine, quinidine or theophylin. The drug is also not affected by simultaneous use of Maalox or Metoclopramid.

omeprazol may increase the concentration of cyclosporin in the blood.

omeprazol increases the effect of antibiotic eradication H. pylori.

Omeprazole inhibits the metabolic of drugs metabolized by the enzyme system in the liver's cytocrom P450 and can increase the concentration of diazepam, phenytoin and warfarin in the blood. The metabolism of diazepam makes the effect of the drug longer. With a dose of 40mg/day omepraxol inhibits phenytoin metabolism and increases the concentration of phenytoin in the blood but the dose of omeprazol 20mg/day has much weaker interaction. Omeprazol inhibits the metabolism of warfarin but rarely changes bleeding time.

omeprazol increases Dicoumarol's anticoagulant effect.

omeprazol reduces nifedipine metabolism at least 20% and may increase the effect of nifedipine.

Clarithromycin inhibits omeprazol metabolism and makes omeprazol levels double.

Cavalry

For intravenous solution, omeprazol must be mixed with a solvent of distilled water injected or 0.9%sodium chloride. Do not use other solvents.

Do not mix, or mix omeprazol solution to intravenously with other intravenous injection solutions.

Storage

Put in a dry place, avoid light, temperature below 30⁰C.

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