EFFE EF effervescence EF longevity Pharma analgesic, fever reduction (5 blisters x 4 tablets)

Dosage form Effervescent tablet
Specifications Box of 5 blisters x 4 tablets
Ingredient Paracetamol
Indication Fever, dysmenorrhea, cold, headache, migraine, body aches, inflammation, toothache
Contraindication Anemia

Ingredient

Thành phần cho 1 viên

Composition information	Content
Paracetamol	500mg

Uses

Indications

Tovalgan EF bubbling tablets containing paracetamol is an analgesic and reducing agent used in the following cases:

Mild -to moderate mild pain includes: headache, colds or flu, sore throat, menstrual pain, muscle aches, pain after vaccination or tooth extraction, toothache, pain in osteoarthritis, migraine.

fever.

Pharmacy

paracetamol (acetaminophen or N - acetyl - p - aminophenol) is a substance that is active in phenacetin, an effective analgesic - antipyretic that can replace aspirin; However, unlike aspirin, paracetamol is not effective in treating inflammation. With equal dose in grams, paracetamol has analgesic and antipyretic effects similar to Aspirin.

paracetamol reduces the body temperature in fever, but rarely reduces the body temperature in normal people. The drug acts on the hypothalamus causing cooling, increasing heat due to vasodilation and increasing peripheral blood flow.

paracetamol, with treatment dose, less impact on the cardiovascular and respiratory system, does not change acid -base balance, does not cause irritation, ulcers or stomach bleeding like when using salicylate, because paracetamol does not work on the whole body cyclooxygenase, only affect cycloxygenase/prostaglandin of central nervous system. Paracetamol does not work on platelets or bleeding time.

When overdose of paracetamol, a metabolic substance is N - Acetyl - Benzoquinonimin that is toxic to the liver. Normal dose, paracetamol well tolerated, there are not many side effects of aspirin.

pharmacokinetic

absorption

Paracetamol is quickly absorbed and almost completely through the gastrointestinal tract. The peak concentration of plasma is within 30 to 60 minutes after drinking with the dose of treatment.

Distribution

Paracetamol is distributed quickly and evenly in most body tissues. About 25% Paracetamol in the blood combined with plasma protein.

Elimination

The half -life of paracetamol plasma is 1.25 - 3 hours, which can last for toxic doses or in patients with liver damage. After the treatment dose, 90 to 100%of the urine can be found on the first day, mainly after the liver combination with glucuronic acid (about 60%), sulfuric acid (about 35%) or cysteine (about 3%); also detected a small amount of hydroxyl metabolites - chemical and reducing acetyl.

Children are less likely to glucuro than drugs than adults. Paracetamol is N - hydroxylation by cytochrom P450 to create N - Acetyl - Benzoquinonimin, an intermediate reaction. This metabolic substance normally reacts with sulfhydryl groups in glutathion and thus deducted activity.

However, if taking high doses of paracetamol, this metabolic is formed in sufficient amount to exhaust the glutathion of the liver; In this situation, its reaction to the sulfhydryl group of liver protein increases, which can lead to liver necrosis.

Before taking EFFE EF effervescence EF longevity Pharma analgesic, fever reduction (5 blisters x 4 tablets)

How to use

Dissolve 1-2 capsules in at least half a cup of water.

Dosage

Each time using 1-2 tablets 4 hours apart, use no more than 4g/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Expression:

Paracetamol poisoning may be due to a single -dose, or a large dose of paracetamol (e.g. 7.5 - 10g per day, for 1-2 days), or for long -term medication. Liver necrosis depends on the dose is the most serious toxic effect due to overdose and can be fatal.

Nausea, vomiting, and abdominal pain usually occur within 2-3 hours after taking the poisonous dose of the drug. Methemoglobin - Blood, leading to purple blue, mucous and nail is a characteristic sign of acute poisoning P - Aminophenol; A small amount of sulfhemoglobin can also be produced. Children tend to create methemoglobin easier than adults after taking paracetamol.

When severe poisoning, the card initially stimulated the central nervous system, agitated and delirious. Next can be inhibiting the central nervous system; Stunned, lower body temperature; tired; Breathing fast, shallow; fast, weak, uneven circuit; Low blood pressure; and circulation.

Vascular collapse due to relative hypoxia and central inhibition effects, this effect only occurs in huge doses. Shock may occur if a lot of vasodilation. The suffocating convulsions may occur. Often coma occurs before dying suddenly or after a few days of coma.

Clinical signs of liver damage become clearly within 2 to 4 days after taking toxic doses. Aminotransferase plasma increases (sometimes very high) and the concentration of bilirubin in plasma can also increase further, when the liver lesions spread, the long prothrombin time.

may be 10% of patients with untreated poisoning that have serious liver damage; Among them 10% to 20% finally die from liver failure. Acute renal failure also occurs in some patients. The liver biopsy detects the central necrosis of the lobe except the area around the door vein. In cases of non -death, liver lesions recover after weeks or months.

Treatment:

Early diagnosis is important in the treatment of paracetamol overdose. There are methods to quickly determine the concentration of drugs in plasma. However, do not delay treatment while waiting for the test results if the history is suggested to overdose. When severe poisoning, it is important to treat positive support. Need to wash the stomach in any case, preferably within 4 hours after drinking.

The main detoxification is the use of sulfhydryl compounds, perhaps partly due to the addition of glutathion reserves in the liver.

n-acetylcysteine works when taken or intravenously. Must give the drug immediately if less than 36 hours after taking paracetamol. Treatment with N - Acetylcysteine is more effective when giving the drug for less than 10 hours after taking paracetamol.

When given, dilute N - Acetylcystein solution with water or drink without alcohol to achieve a 5% solution and must be taken within 1 hour after mixing. Give N - Acetylcystein with the first dose of 140mg/kg, then give 17 more doses, each dose of 70mg/kg 4 hours apart. Termination of treatment if the paracetamol test in plasma shows the risk of low liver toxicity.

The unwanted effect of N - Acetylcystein includes skin rash (including urticaria, no need to stop the drug), nausea, vomiting, diarrhea, and anaphylactic reaction.

If there is no n - acetylcystein, methionine may be used. Also can use activated carbon and/or salt bleach, they have the ability to reduce the absorption of paracetamol.

High -dose sodium bicarbonate can cause symptoms in the digestive tract such as belching and nausea. Moreover, high -dose sodium bicarbonate can cause blood alkalization, need to monitor electrolytes and control patients appropriately.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Tavagan EF, you may experience unwanted effects (ADR).

Common, ADR> 1/100

No report.

Uncommon, 1/1000

No report.

Not determined frequency

Skin and side effects: sensitive, skin rash, urticaria.

Respiratory: Heavy bronchospasm has been known in patients sensitive to aspirin and other non-steroid anti-inflammatory drugs.

Hematopoietic system: Organs.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Tolvagan EF is contraindicated in the following cases:

Patients with anemia many times or heart, lung, kidney or liver disease.

Personal hypersensitivity to paracetamol.

Patients with glucose deficiency - 6 - Phosphate dehydrogenase.

Caution when using

The drug contains sodium ions, so it should not be used tovalgan EF for patients who abstain from salt.

Do not use with other drugs containing paracetamol.

To be out of reach of children.

If the symptoms are still tough, consult a doctor.

Doctors need to warn patients on signs of serious skin reactions such as Steven - Jonhson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

The ability to drive and operate machinery

There is no significant effect.

Pregnancy

studies with paracetamol in humans and animals have not yet identified any risk of paracetamol for pregnant women or embryo development.

Breastfeeding period

Human studies have not yet identified any risk of paracetamol for nursing mothers or breastfed babies. Paracetamol passed the placenta fence and was secreted into breast milk.

Medicinal interaction

Long -doses of high -dose Paracetamol increases the anticoagulant effect of COUMARIN and conducting indandion. This effect seems less or not clinically important, so paracetamol is more popular than salicylate when it is necessary to relieve mild pain or reduce fever for patients who are using cooumarin or indandion.

Need to pay attention to the likelihood of serious antipyretics in patients with phenothiazine and cooling therapy.

Out of alcohol too much and long can increase the risk of paracetamol toxic to the liver.

Anti -convulsions (including Phenytoin, Barbiturat, Carbamazepin) that causes enzyme induction in the liver microsom, which can increase the toxicity of the liver toxicity of paracetamol due to increased drug metabolism into toxic substances to the liver. In addition, simultaneous use of isoniazid with paracetamol can also lead to an increase in the risk of toxicity to the liver, but it has not been determined the exact mechanism of this interaction.

The risk of paracetamol causes liver toxicity is worth a person in patients with paracetamol doses larger than the recommended dose while taking anti -convulsions or Isoniazid. Often do not need to reduce the dose in patients with simultaneous doses of paracetamol treatment and anti -convulsions; However, patients must restrict self -use of paracetamol while taking anti -convulsions or isoniazid.

Storage

In a cool dry place, temperatures below 30 ° C, avoid light.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.