Effer-Paralmax 500 Boston effervescent tablets reduce mild to moderate pain, headache, toothache (5 blisters x 4 tablets)

Dosage form Effervescent tablet
Specifications Box of 5 blisters x 4 tablets
Ingredient Paracetamol
Indication Sore throat, sinusitis, fever, dysmenorrhea, cold, headache, migraine, body aches
Contraindication Anemia

Ingredient

Composition information	Content
Paracetamol	500mg

Uses

Indications

Effer - Paralmax indicated treatment in the following cases:

The drug is used to treat symptoms of pain and/or fever such as headache, influenza, toothache, muscle aches, dysmenorrhea.

pharmacokinetics

No data.

Before taking Effer-Paralmax 500 Boston effervescent tablets reduce mild to moderate pain, headache, toothache (5 blisters x 4 tablets)

How to use

Take oral use.

Completely dissolve the pill in a large glass of water and drink.

If a child has a fever of 38.5 ° C, take the following steps to increase the effectiveness of the drug:

Remove children's clothes.

Give children more liquid.

limited treatment time:

up to 5 days in pain cases.

up to 3 days in fever cases.

Dosage

Dosage must be calculated by the child's weight. Age corresponding to the weight is presented below for reference. To avoid the risk of overdose, it is necessary to check and confirm the drugs being used (including prescription and non -prescribing drugs) without paracetamol. This drug is only for adults and children weighing over 33kg (about 10 years old).

Children:

daily paracetamol dose is calculated by children's weight, the age of children is only for reference and instructions. If you do not know your weight, you need to weigh the most appropriate dose.

Paracetamol has many different types of dose for appropriate treatment depending on the weight of each child.

The daily dosage of paracetamol depends on the child's weight: about 60mg/kg/day, divided into 4 times or 6 times, equivalent to about 15mg/kg every 6 hours, or 10mg/kg every 4 hours. The maximum daily dose must not exceed 3G.

Do not take the whole pill. Completely dissolve the tablet in a glass of water before drinking.

weight (kg) age* (year) Paracetamol content (Number of tablets) per dose The minimum distance between drug use (hour) Maximum daily dose (tablets) 50 10 to 500 mg (1 tablet) 6 4 (2000mg) (3000mg)

For children who do not belong to the above table: Use other appropriate dose formats.

Normally, it is not necessary to exceed 3000mg of paracetamol a day (about 6 tablets a day). However, in the case of a lot of pain and as recommended by the doctor, the maximum dose of the drug may increase to 4000mg a day (about 8 tablets a day).

However:

The dose higher than 3000mg of paracetamol a day must have a doctor's opinion.

500 mg Paracetamol (1 tablet)/dose, every 4 - 6 hours. Maximum daily dose: 6 capsules (3000 mg).

In patients with severe renal failure, the minimum distance between each drug should be adjusted according to the following table:

Creatinine clearance Medication distance Now

In patients with chronic liver disease or liver disease, it is still possible to work, especially in patients with liver cell insufficiency, chronic alcoholism, prolonged malnutrition (poor liver glutathione reserves), and dehydration, dosage should not exceed 3G/day.

Elderly patients: No dose adjustment requirements.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

may be at risk of poisoning, especially in people with liver disease, chronic alcoholism, in prolonged malnourished patients and enzyme users.

In particular, overdose can lead to death in these cases.

Symptoms of poisoning usually appear in the first 24 hours, including nausea, vomiting, anorexia, re -skin, uncomfortable and sweating.

Overdose when taking a dose higher than 7.5g of paracetamol in adults, or 140mg/kg body weight in children will cause inflammation and cancel liver cells, which can cause complete and non -recovery liver necrosis, leading to liver cell failure, metabolic acid infection and brain disease leading to coma and death.

At the same time, there is an increase in liver transaminase levels (AST, ALT), lactate dehydrogenase and bilirubin along with decreased prothrombin levels, which can occur from 12 to 48 hours after taking the drug.

Clinical symptoms of liver damage often become pronounced at first after 2 days, and reach a maximum after 4-6 days.

How to handle

Take it immediately to the hospital. NAC can have a protective level even after 16 hours.

Symptomatic treatment. In most cases, the level of liver transaminase is normal after 1-2 weeks with a fully restored liver function.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Effer - Paralmax you may experience unwanted effects (ADR):

Unwanted effects are classified according to the following frequency: Very common (≥ 1/10), common (≥ 1/100 to

As well as for all drugs, this drug can cause, in some people, reactions to severe or mild degrees.

The following side effects have been reported in after -sales monitoring but the rate of appearance (frequency) is not known.

System (SOC) group frequency

Neutral leukemia

leukopenia

Abdominal pain

Unknown liver disorders

Phu Quincke

hypersensitivity

Inreat Inr

Redders

rash

Excellent body syndrome, poisoned skin necrosis syndrome, Stevens-Johnson syndrome

circuit disorders unknown hypotension (symptoms of hypersensitivity)

Notify the physician with unwanted effects when using the drug.

If seriously ADR occurs, Paracetamol must be stopped. Regarding treatment, viewing overdose.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Effer - Paralmax contraindicated in the following cases:

allergies to paracetamol, propacetamol hydrochloride (the precursor of paracetamol) or with any ingredient of the drug.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Read the instructions carefully before use. If you need more information, please consult your doctor.

Bác sĩ cần cảnh báo bệnh nhân về các phản ứng phụ nghiêm trọng trên da, mặc dù tỉ lệ mắc phải là không cao nhưng nghiêm trọng, thậm chí đe dọa tính mạng bao gồm hội chứng Stevens - Johnson (SJS), hội chứng hoại tử da nhiễm độc: Toxic epidermal necrolysis (TEN) hay hội chứng Lyell, hội chứng ngoại ban mụn mủ toàn thân cấp tính: Acute generalized exanthematous pustulosis (AGEP) With the symptoms described as follows:

Stevens-Johnson syndrome (SJS): is an allergic to puffiness, localized puffiness around natural cavities: eyes, nose, mouth, ears, genitals and anus. In addition, it may be accompanied by high fever, pneumonia, liver dysfunction. Diagnosis of Stevens-Johnson syndrome (SJS) when there are at least 2 naturally damaged cavities. Eye mucosa damage: corneal inflammation, pus conjunctivitis, corneal ulcer; Damage to gastrointestinal mucosa: stomatitis, mouth mucosa, pharyngeal ulcer, esophagus, stomach, intestines; damage to the mucous membranes of genital tract, urinary tract; In addition, there are serious systemic symptoms such as fever, gastrointestinal bleeding, pneumonia, glomerulonephritis, hepatitis, ... The death rate is high 15 - 30%. Damage often appears in folds such as armpits, groin and face, then can spread the whole body. Systemic symptoms are often fever, neutral leukemia test increased.

When detecting signs of rash on the first skin or any other hypersensitive reactions, patients need to stop using the drug. People who have had severe skin reactions caused by Paracetamol must not use the drug again and when they come to medical examination and treatment, they need to notify the medical staff on this issue.

Warning when taking drugs

must immediately notify the doctor when using overdose or accidentally taking too high dose.

This drug contains paracetamol. Do not use in combination with other drugs that also contain paracetamol to avoid exceeding the daily dose.

Paracetamol dose is higher than the recommended dose causing the risk of serious liver damage. Clinical symptoms of liver damage are usually first recorded after 1 to 2 days of paracetamol overdose. Maximum symptoms of liver damage are often observed after 3-4 days, need to use antidote as soon as possible.

Use paracetamol carefully in the following cases:

Liver cell failure. Eat, incorrect or worn, prolonged malnutrition (ie inferior to glutathione reserves in the liver).

Precautions when using:

Do not continue treatment if not consulted by a doctor in case of persistent pain symptoms for more than 5 days or a fever more than 3 days, or the drug is not effective, or seeing other symptoms.

Cautious excipients:

Sodium: This drug contains 380.8 mg of sodium (which is the main ingredient in the table) in each dose unit, equivalent to 19.5% of the maximum daily sodium diet is recommended for adults. Aspartam is a rich source of nutrition phenylalanin. This substance can be harmful if the patient has phenylceton, a rare genetic disorder that causes phenylalanin accumulation because the body cannot eliminate it as usual. Benzoate salt can increase the risk of jaundice and yellow eyes in newborns (4 weeks of age or less).

The effect of the drug on driving and operating machinery

has no effect of the drug on the ability to drive and operate machinery.

Use drugs for women during pregnancy and lactation

Pregnant women

Epidemiology data from the use of Paracetamol treatment by oral shows that there is no unwanted effect on pregnant women or on embryo or infant health.

Studies on reproductive function with oral paracetamol have not shown any deformities or toxicity to the embryo. Later data on pregnant women overdose Paracetamol shows no increased risk of deformities.

However, Paracetamol should only be used for pregnant women after being carefully evaluated between treatment benefits and risks. In pregnant patients, recommended doses and drug use time must be closely monitored.

breastfeeding women

After drinking, a small amount of paracetamol is secreted into breast milk. There have been reports on the rash in breastfeeding. Although paracetamol is considered to be suitable for nursing women, it is necessary to be cautious when using paracetamol for women during breastfeeding. According to the general principle, pregnant or lactating women, before taking a drug, should consult a doctor or pharmacist.

Interactive drugs

Need to notify the use of paracetamol to the doctor in case of appointment of uric acid measurement or blood sugar levels.

To avoid interactions between drugs, notify your doctor or pharmacist other drugs you are taking or new use, including non -prescribing drugs.

The effect of paracetamol on other drugs

paracetamol may increase the likelihood of unwanted effects when used with other drugs.

Anticoagulant drugs: Concomitant use of paracetamol with cooumarin including warfarin may slightly change the INR. In this case, it is necessary to strengthen the monitoring of the INR index during the combination as well as within 1 week after stopping treatment with Paracetamol.

The effect of other drugs on paracetamol

Phenytoin: Concomitant use with phenytoin can lead to reduction in paracetamol effectiveness and increase the risk of toxicity to the liver. Patients who are being treated with phenytoin should avoid large and/or prolonged paracetamols. Need to monitor patients on toxic signs for

Probenecid: can reduce nearly twice in the clearance of paracetamol by inhibiting its conjugate with glucuronic acid. Paracetamol dose should be considered when used simultaneously with probenecid.

salicylamid: can extend the sale time (t) of paracetamol.

Enzyme induction substances: Be careful when using paracetamol with enzyme induction substances. These substances include (but unlimited): barbiturat, isoniazid, carbamazepine, rifampin and ethanol.

Tyeum of drugs

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

Other drugs

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