Effer-Paralmax C 500/150 Boston Pain Agency, Fever (5 blisters x 4 tablets)

Increase oxalate, nausea, vomiting, heartburn, abdominal spasms, fatigue, redness, headache, insomnia and drowsiness have occurred. After taking the dose of 1 g daily or larger, diarrhea can occur.

Common, ADR> 1/100

Instructions on how to handle ADR

Notify the physician the unwanted effects when using the drug.

Caution when using

Caution with paracetamol

To avoid the risk of an overdose, it is not advisable to use drugs with other preparations containing paracetamol and comply with the recommended maximum dosage (see the dosage and usage section).

Be cautious when using paracetamol for: Patients with weight Doctors need to warn the patient about signs of serious skin reactions such as Steven-Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

Patients need to stop using paracetamol and see a physician as soon as they see a rash or have different symptoms in the skin or sensitive reactions during treatment. Patients with a history of such reactions should not be used in preparations containing paracetamol.

Sometimes there are skin reactions including itchy and urticaria, other sensitive reactions including laryngeal edema, angioedema and anaphylactic reactions that may rarely occur. Platelets, leukopenia and all bloody hematuria have occurred with the use of P-Aminophenol substances, especially when used for large doses. Neutral leukopenia and thrombocytopenic hemorrhage occur when using paracetamol. Rarely loss of granulocytes in patients using paracetamol.

Use paracetamol carefully in patients with anemia before because blue purple may not manifest clearly, although high concentrations at a dangerous level of methemoglobin in the blood.

Caution with vitamin C

Prolonged high doses of vitamins can lead to greasy phenomenon, so when reducing the dose will lead to a deficiency of vitamin C. Large dose of vitamin C during pregnancy leading to scorbut disease in infants.

Increased oxalate oxalate and the formation of calcium oxalate stones in the kidneys may occur when high doses of vitamin C, should avoid high doses of vitamin C for patients with calcium oxalate stones in the kidneys, if necessary, closely monitor oxalate urinary tract. Vitamin C can cause acidification of urine, sometimes leading to urate or cystin precipitate, or oxalate stones, or medications in the urinary tract.

Patients with sickle cell anemia, glucose enzyme deficiency- 6- Phosphate dehydrogenus (G6PD) high doses of vitamin C may have hemolytic. Deep vein thrombosis also occurred when using high doses of vitamin C.

Excessive use and prolonged preparations containing vitamin C can cause enamel corrosion.

Using vitamin C can falsify the results of the glucose test in the urine (fake positive when using the copper sulfate or fake negative reagent when using the oxidase glucose method).

Taking high doses of vitamin C for a long time can cause dangerous heart disease in people with high iron reserves or people infected with tissue.

Be cautious when using high doses, prolonged for pregnant women.

If detected by acute virus liver should be discontinued with drugs.

Vitamin C has a mild stimulating effect, should not take the drug at the end of the day.

Be cautious with the tons of it

Effer-Paralmax C 500/150 contains aspartam, a source of phenylalanin, which can be harmful to patients with phenylceton-di.

Each tablet contains about 566.81 mg of sodium, so pay attention to the daily diet in case the patient has a salt diet.

Use drugs for pregnant or lactating women

Pregnant women

According to epidemiological research data, paracetamol at the dose of treatment does not cause harmful reactions for pregnant women, fetus or infants. Paracetamol overdose for pregnant women does not increase the risk of malformations.

Therefore, paracetamol is safe for pregnant women when used at the treatment doses in a short time. The data shows that Vitamin C is used with treatment doses in pregnant women does not cause any deformities. Drinking large amounts of vitamin C during pregnancy can increase the need for vitamin C and lead to scorbut disease in infants.

Therefore, Effer-Paralmax C 500/150 should be used in pregnant women after evaluating benefits and risks. During treatment, the dosage and treatment time must be strictly followed.

breastfeeding women

paracetamol excreted breast milk in very small amounts. Cases of skin rods have been recorded in breastfed babies. Vitamin C is excreted in breast milk. Therefore, avoid using Effer-Paralmax C 500/150 in breastfeeding women

affects the ability to drive and operate machinery

Paracetamol does not affect or negatively affect the operator, are driving a train, higher working people and other cases.

Drug interaction

Interacting with paracetamol

Anti -blood dynamic drugs: The anticoagulant effect of anticoagulants can increase slightly when using prolonged paracetamol accompanied by increased risk of bleeding.

Phenothiazin: It is necessary to pay attention to the possibility of serious heat lowering the patient using phenothiazin and cooling (like paracetamol).

Alcohol: Excessive and long drinking can increase the risk of Paracetamol's liver toxicity.

The liver enzyme induction drugs and some anti -convulsions (carbamazepin, barbiturates, isoniazid, rifampicin): can increase the toxicity of Paracetamol.

Isoniazid and anti -tuberculosis drugs: increasing toxicity of paracetamol for the liver.

Phenytoin: reduces paracetamol effects and increases the risk of liver toxicity when shared.

Probenecid: reduces half of paracetamol clearance by inhibiting the combination of paracetamol with glucuronid acid. Paracetamol treatment should be reduced when used with probenecid.

salicylamid: can extend the sale time of paracetamol.

Interaction with vitamin C

Elemental iron: Simultaneously used in the ratio of over 200 mg of vitamin C with 30 mg of elemental iron to increase iron absorption through the stomach, however, most patients have the ability to absorb iron oral iron fully without having to use Vitamin C simultaneously.

Aspirin: simultaneously use vitamin C with aspirin increases the secretion of vitamin C and reduces the secretion of aspirin in urine.

Fluphenazin: Concomitant use of vitamin C and fluuphenazin leads to reduced plasma fluhenazin levels.

Other drugs: Vitamin C acidic urine so it can alter the excretion of other drugs.

Vitamin B12: Vitamin C is high doses that can destroy vitamin B12, it is necessary to advise patients to avoid taking high doses of vitamin C within an hour before and after taking vitamin B12.

Selenium: Vitamin C is high doses that can reduce the absorption of selenium (drinking at least 4 hours apart).

Testing: Because vitamin C is a powerful reducing agent, it affects many tests based on oxidation-reducing reactions. The presence of vitamin C in urine increases the amount of glucose if quantitative with copper reagent (II) sulfate and fake glucose amount if quantitative by glucose oxydase.

Deferoxamin: With high doses of vitamin C, it will function for abnormal heart function, including symptoms of acute heart failure (this symptom will reverse when stopping using Viatmin C).

Aluminum hydroxyd and amphetamine: Vitamin C can increase the effects of hydroxyd aluminum and reduce the effect of amphetamine.