Efferalgan bullets 300mg upsa sas analgesic, reducing fever (10 tablets)

Dosage form Bullet
Specifications Box of 10 tablets
Ingredient Acetaminophen

Ingredient

Thành phần cho 1 viên

Composition informationContent
Acetaminophen300mg

Uses

indicated

Efferalgan 300mg is indicated in the following cases:

  • Treatment of pain and/or fever such as headache, condition such as flu, toothache, muscle aches.

    pharmacokinetics

    No report.

    • Before taking Efferalgan bullets 300mg upsa sas analgesic, reducing fever (10 tablets)

    How to use

    Use rectal sugar.

    If your child has a fever above 38.5 ° C, take the following steps to increase the effectiveness of drug use:

  • Remove children's clothes.
  • Give children more liquid.
  • Do not leave children in too hot places.
  • If needed, bathing children with warm water, with a temperature lower than 2 ° C compared to the child's body temperature.

    • Frequency and time of use

    Take the drug to avoid oscillations of pain or fever. In children, it is necessary to have a evenly gap between each drug, both day and night, so it is about 6 hours, or at least 4 hours.

    kidney failure

    In patients with severe renal failure, the minimum distance between each drug should be adjusted according to the following table:

    Creatinine clearance

    Medication distance

    6 hours

    8 hours

    In patients with chronic liver disease or liver disease, it is still active, especially in patients with liver cell insufficiency, chronic alcoholism, prolonged malnutrition (poorly reserved glutathione in the liver), and dehydration, dosage should not exceed 3 g/day.

    Therefore, paracetamol should be used carefully in patients with liver failure and contraindicated when there is liver disease that is active, especially alcohol hepatitis, due to CYP 2E1 induction, which increases the metabolitus of paracetamol toxic liver toxicity.

    Older patients

    No dose adjustment requirements in older patients.

    Dosage

    Paracetamol dose is calculated by weight of children, children's age for reference, instructions.

    If you do not know your weight, you need to weigh the most appropriate dose.

    The appropriate age corresponds to the weight presented below just for reference. To avoid the risk of overdose, check for oral medications at the same time (both prescribed and not prescribed drugs) must not contain paracetamol. Overdose due to unintentional can lead to severe liver damage and death.

    paracetamol has many different types of dose for appropriate treatment depending on the weight of each child.

    Daily dose of paracetamol recommends is about 60 mg/kg/day, divided into 4 use, about 15 mg/kg every 6 hours. Because there is a risk of rectal irritation, the treatment with ammunition is shorter as possible, should not exceed 4 times/day and should be replaced as soon as possible by oral.

    The type of bullet is not appropriate in case of diarrhea.

    See specific recommendations as the table below:

    weight (kg)

    Age

    appropriate*

    Paracetamol content/each dose (mg)

    Number of bullets/each dose

    Minimum distance of using drugs (hours)

    Maximum daily dosage (bullets)

    15 -

    3 -

    300 mg

    1

    6 hours

    1200 mg

    (4 bullets)

    The use of age is based on local standard development curves.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

    do when overdose?

    There is also a risk of overdose, especially in liver disease, chronic alcoholism, prolonged malnutrition patients and enzyme users. Especially overdose can lead to death in these cases.

    Signs and symptoms

  • Nausea, vomiting, anorexia, pale, abdominal pain, discomfort and sweat often appear in the first 24 hours. At the same time, there is an increase in liver transaminase, lactate dehydrogenase and bilirubin along with a reduction in prothrombin can occur from 12 to 48 hours after taking the drug. The clinical symptoms of liver damage are usually pronounced at first after 1 to 2 days, and reach a maximum after 3-4 days.

    • Emergency measures

  • Take it immediately to the hospital. (Take or intravenously), if possible, before the 10th hour after overdose.
  • Symptomatic treatment. In most cases, the liver transaminase returns to normal after 1-2 weeks with the full recovery of the liver function. However, in case of being too heavy, it may be necessary to graft the liver. However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

    • Side Effects

    When using Efferalgan Bullets 300 mg, you may experience unwanted effects (ADR).

    Common, ADR> 1/100

    No report.

    Uncommon, 1/1000

    No report.

    Not determined frequency

    Blood and lymphatic system: reducing the amount of platelets.

    Digestive system: abdominal pain, diarrhea.

    Liver system: liver failure, liver necrosis, hepatitis.

    The immune system: Anaphylaxis, hypersensitivity, fleet.

    Clinical: increased liver enzymes.

    Skin and subcutaneous tissue: Red rash, itching, rash, urticaria, external pustules syndrome, acute body, poisoned skin necrosis syndrome, Stevens - Johnson syndrome.

    Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Efferalgan 300 bullets contraindicated in the following cases:

    Patients with a history of allergies to paracetamol or with propacetamol hydrocloride (the precursor of paracetamol) or the ingredients of the drug.

    Severe liver disease.

    new anal or rectal inflammation or rectal bleeding.

    Caution when using

    Maximum recommendations

    For children weighing from 15 to

    Using bullets at risk of local irritation, frequency and intensity increase over time, the time of drug and dose.

    Paracetamol dose is higher than the recommended dose that causes very serious risk of liver damage. The doctor should warn the patient about signs of serious skin reactions such as Stevens - Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

    Use paracetamol carefully in the following cases:

    Liver cell failure.

    Severe renal failure (Creatinine purification ≤ 30 ml/min).

    Lack of glucose enzyme - 6 - phosphate - dehydrogenase (G6PD) (can lead to hemolytic anemia).

    Chronic alcoholism, too much alcohol (≥ 3 cups of alcohol per day).

    Anorexia, incorrect or corrosion, prolonged malnutrition (ie inferior to glutathione reserves in the liver).

    Dehydration, reducing blood volume.

    The ability to drive and operate machinery

    is unrelated.

    Pregnancy

    Research conducted on animals has not shown that paracetamol has a toxic or toxic toxicity.

    In clinical studies, epidemiological research results seem to eliminate deformities and toxic to the embryo of paracetamol. Later data on pregnant women overdose Paracetamol shows no increased risk of deformities.

    However, Efferalgan 300mg should only be used for pregnant women after being carefully evaluated between treatment benefits and risks. In pregnant patients, recommended doses and drug use time must be closely monitored.

    The period of breastfeeding

    After drinking, a small amount of paracetamol is secreted into breast milk. There have been reports on the rash in breastfeeding. Although Paracetamol is considered to be suitable for nursing women, it is necessary to be cautious when using Efferalgan for women during breastfeeding.

    Drug interaction

    Efferalgan 300mg's effect on other drugs

    Anticoagulant drugs

    Simultaneous use of paracetamol with cooumarin including warfarin may slightly change the value of INR. In this case, it is necessary to strengthen the monitoring of the Inr value during the combination of use as well as within 1 week after stopping treatment with paracetamol.

    Interaction with laboratory tests

    Using paracetamol may interact with blood uric acid tests by phosphotungstic acid and blood glucose tests by oxidase glucose - peroxidase.

    The effect of other drugs on Efferalgan 300mg

    phenytoin

    can reduce the effectiveness of paracetamol and increase the risk of toxicity for the liver when used simultaneously. Patients who are being treated with phenytoin should avoid large and/or prolonged paracetamols. Need to monitor patients on signs of toxicity for the liver.

    Probenecid

    can reduce nearly twice in paracetamol's clearance by inhibiting its conjugate with glucuronic acid. Paracetamol dose should be considered when used simultaneously with probenecid.

    salicylamide

    can extend the sale time of paracetamol.

    Enzyme induction substances

    Be careful when using paracetamol with enzyme induction substances such as barbiturates, isoniazid, carbamazepine, rifampin and ethanol.

    Storage

    Storage below 30 ° C.

    To be out of reach of children.

    Other drugs

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