Efferalgan effervescent powder 80mg upsa sas analgesic, reducing fever (12 packs)

Dosage form Effervescent powder mixed oral solution
Specifications 12 package box
Ingredient Paracetamol

Ingredient

Composition information	Content
Paracetamol	80mg

Uses

indications

Efferalgal 80mg drug used to treat pain and/or fever such as headache, condition such as flu, toothache, muscle aches.

Medicines used for children weighing 6 - 20 kg.

Pharmacokinus

paracetamol is an analgesic and antipyretic with mild anti -inflammatory activity. Unlike traditional nonsteroidal anti -inflammatory drugs (NSAID), paracetamol does not inhibit platelet function at the dose of treatment.

Mechanism of action: The exact mechanism of paracetamol analgesic and antipyretic effects has not been determined. The mechanism of action can be related to the effects at the central and peripheral.

Pharmacokinetics

absorption

Paracetamol when taken will be absorbed quickly and completely. The peak concentration of plasma is about 10-60 minutes after drinking.

Distribution

paracetamol is quickly distributed into most tissues.

In adults, the distribution of Paracetamol's distribution is about 1-2 liters/kg and in children between 0.7 - 1.0 liters/kg.

Paracetamol does not strongly connect with plasma proteins.

Metabolism

Paracetamol is metabolized mainly in the liver in two main paths in the liver: associated with glucuronic acid and associated with sulfuric acid; Combined with sulfuric acid quickly saturated when taking a higher dose but still within the scope of treatment. The saturation of the glucoronid process appears only when the dose is higher, toxic to the liver.

A small part (less than 4%) is metabolized by Cytochrom P450 forming a high reaction mediator (N-acetyl Benzoquinoneimin), under normal usage conditions, this intermediate will be detoxified by glutathion reduction and is eliminated in urine after connecting with cystein and mercapturic acid. However, when poisoning with high doses of paracetamol, the amount of metabolites has this toxicity increases.

Elimination

Paracetamol metabolites are mainly eliminated in urine, in adults, about 90%of the dose is excreted for 24 hours, mainly in the form of glucuronid complex (about 60%) and sulfate complex (about 30%). Less than 5% are eliminated in constant form.

Selling time in plasma is about 2 hours.

Before taking Efferalgan effervescent powder 80mg upsa sas analgesic, reducing fever (12 packs)

How to use

Take oral use.

Pour the powder into the cup and then add a little liquid drink (such as water, milk, juice), drink immediately after completely dissolved.

Dosage

This type of drug is for children weighing from 6 to 20 kg (about 1 to 7 years old).

Dosage must be calculated according to the child's weight.

The appropriate age corresponds to the weight presented below just for reference. To avoid the risk of overdose, it is necessary to check and confirm the accompanying drugs (including prescription and non -prescription drugs) without paracetamol.

Efferalgan should be used at a dose of 10 -15 mg/kg/dose, every 4 to 6 hours, to the maximum daily dose of 60 mg/kg/day.

Maximum daily dose must not exceed 3G.

Weight (kg) appropriate age* (year) Paracetamol/dose (mg) Number of packages/dose numbers

minimum mineral mineral use (hour) Maximum daily dosage (pack) 8 1 to 80 1 6 4 (320 mg) 8 to 11 Mg)

11 to 3 to 160 2

6 8 (640 mg) 7 160 2 4 12 (960 mg) ≥ 20 examination.

Renal failure: In patients with severe renal impairment, the minimum distance between each drug should be adjusted according to the following table:

Creatinine clearance Drug usage distance ml/minute 8 hours

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Signs and symptoms

may be at risk of poisoning, especially in patients with prolonged malnutrition and enzyme users. In particular, overdose can lead to death in these cases.

Symptoms usually appear in the first 24 hours, including nausea, vomiting, anorexia, pale skin, uncomfortable and sweating.

Overdose when taking a dose higher than 7.5g of paracetamol in adults, or 140 mg/kg body weight in children will cause inflammation and cancel liver cells, which can cause complete and non -recovery liver necrosis, resulting in liver cell failure, metabolic acid infections and brain disease leading to coma and death.

At the same time, there is an increase in liver transaminase levels (AST, ALT), lactate dehydrogenase and bilirubin along with decreased prothrombin levels, which can occur from 12 to 48 hours after taking the drug. The clinical symptoms of liver damage often become pronounced at first after 1-2 days, and reach a maximum after 3-4 days.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Side effects may be encountered when taking Efferalgan 80mg including:

Blood and lymphatic disorders: reducing the amount of platelet, neutropenia, leukopenia.

Disorders of skin and subcutaneous tissue: urticaria, erythema, rash, external pustules syndrome, acute body, poisoned skin necrosis syndrome, Stevens-Johnson syndrome.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

This drug is not used in the following cases:

Know there is an allergy to paracetamol or with propacetamol hydrochloride (the precursor of paracetamol) or other ingredients of the drug. Sorbitol's face).

Be cautious when using

in case of severe liver disease or kidney disease (consulting your doctor before using paracetamol).

Anorexia, incorrect or corrosion, prolonged malnutrition (poorly liver glutathion reserves).

Dehydration, reducing blood volume.

Doctors need to warn patients on signs of serious skin reactions such as Stevens-Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute overseas acne syndrome (AGEP).

If symptoms of pain persist for more than 5 days, or a fever for more than 3 days, or the drug is not effective enough, or seeing other symptoms, no treatment without consulting your doctor.

Due to sorbitol, this drug is not used in case of intolerance to fructose.

In patients who are following the salt diet, it is important to remember that each pack contains 66mg of sodium to calculate the daily diet.

The ability to drive and operate machinery

does not affect.

pregnancy

does not apply.

The period of breastfeeding

does not apply.

Interactive drug

If the doctor appoints to measure uric acid or blood sugar levels, you need to report to your doctor as your child is taking this medication.

Effective effects on other drugs: Efferalgan may increase the likelihood of unwanted effects when used with other drugs.

Anticoagulant: Paracetamol may increase the effects of anticoagulants.

Effect of other drugs on Efferalgan:

Concentrated use with phenytoin can lead to reduced paracetamol effectiveness and increase the risk of toxicity to the liver. Patients who are being treated with phenytoin should avoid large and/or prolonged paracetamols. Need to monitor patients on signs of toxicity for the liver.

Probenecid may reduce nearly twice in paracetamol's clearance by inhibiting its conjugate with glucuronic acid. Paracetamol dose should be considered when used simultaneously with probenecid.

salicylamid can extend the disposal time (t1/2) of paracetamol.

Enzyme induction substances: Be careful when using paracetamol with liver enzyme induction substances such as barbiturat, isoniazid, carbamazepine, rifampicin and ethanol ...

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

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