Efferhasan effervescent powder 250mg analgesic, reducing fever (30 packs)

Dosage form Box of 30 packs x 1.6g
Specifications Paracetamol

Ingredient

Composition information	Content
Paracetamol	250mg

Uses

Indications

Efferhasan drug 250 mg is indicated in the following cases:

Treatment of pain relief and mild to medium fever, especially for patients with contraindications or non -tolerance.

Treatment of mild pains without organ origin such as colds, flu, headache, ear pain, sore throat, dengue fever, bacterial infection, viral infection, tonsillitis, tooth extraction, toothpe, toothache, post-vaccination reactions, postoperative, muscle pain, sprains, joint pain.

Pharmacokinus

paracetamol is an analgesic - antipyretic but not effective for inflammation treatment. Paracetamol reduces the body temperature of the patient, but rarely reduces the body temperature in normal people. The drug acts on the hypothalamus, causing cooling off, increasing heat due to vasodilation and increased peripheral blood flow.

Paracetamol with a low dosage that affects the cardiovascular and respiratory system, does not change acid -base balance, does not cause irritation, scratches or stomach bleeding like when using salicylate, because paracetamol only affects cyclooxygenase/prostaglandin of the central nervous system. Paracetamol does not work on platelets or bleeding time.

pharmacokinetics

absorption:

Paracetamol is quickly absorbed and almost completely through the gastrointestinal tract. Carbon hydrate -rich foods reduce the absorption rate of paracetamol.

Distribution:

Paracetamol is distributed quickly and evenly in most body tissues. About 25% Paracetamol in the blood combined with plasma protein.

Metabolism:

Paracetamol complex in the liver with glucuronic acid (about 60%), sulfuric acid (about 35%), or cysteine (about 3%), also detected a small amount of hydroxyl metabolites - chemicals and reducing acetyl.

Era:

The half -life of paracetamol plasma is 1.253 hours, which can last for toxic doses or in patients with liver damage. After the treatment dose, 90 -100% of the urine can be found in the first day.

Before taking Efferhasan effervescent powder 250mg analgesic, reducing fever (30 packs)

How to use

Dissolve the nuggets of the drug in water, take after the nuggets of the drug completely dissolve.

Dosage

adults and children> 12 years old:

Take 2-4 packs/time every 4 - 6 hours, maximum 16 packs/day.

Children:

Take 4 - 6 hours when necessary, up to 4 times/24 hours with the following doses:

1 year old - 5 years old: 1/2 - 1 pack/time.

6 years old - 12 years: 1-2 packs/time. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms:

The liver necrosis depends on the most serious acute toxic effect due to overdose and may cause death.

Nausea, vomiting and abdominal pain usually occur within 2-3 hours after taking the poison of the drug. Methemoglobin - Blood, leading to purple blue, mucosal and nails are a specific sign of acute poisoning P - Aminophenol. Children tend to create methemoglobin easier than adults after taking paracetamol.

When severe poisoning, it may initially stimulate the central nervous system, agitation and delusion. Next can inhibit the central nervous system, lower body heat, respiratory failure - circulation, vascular collapse, shock. The suffocating convulsions may occur. Often coma occurs before dying suddenly or after a few days of coma.

Clinical signs of liver damage are significantly within 2-4 days after taking toxic doses. Acute renal failure also occurs a number of patients. In cases of non -liver lesions recover after weeks or months.

Management:

Need to wash the stomach in any case, preferably within 4 hours after drinking.

The main detoxification is the use of sulfhydryl compounds such as N - Acetylcystein supplementing glutathion reserves in the liver. N-acetylcystein must be given immediately if less than 36 hours after taking paracetamol. Treatment with N - Acetylcysteine is more effective when giving medicine for less than 10 hours after taking paracetamol.

When given, dilute N - Acetylcystein solution with water or drink without alcohol to achieve a 5% solution and must be taken within 1 hour after mixing. Give N-acetylcystein oral at the first dose of 140 mg/kg, then give 17 more doses, each dose of 70 mg/kg 4 hours apart. Termination of treatment if the paracetamol test in plasma shows a low risk of liver damage.

If there is no n - acetylcystein, methionine may be used. In addition, activated carbon can be used to reduce paracetamol absorption.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Efferhasan 250, you may experience unwanted effects (ADR).

Uncommon, 1/1000

Skin reactions: usually the erythema, itchy rash, urticaria, sometimes worse and may be accompanied by a fever due to drugs and mucosal lesions.

digestion: Nausea, vomiting. Other disorders: Hemorrhagic disorders (neutropenia, all bloody hemorrhage, thrombocytopenia), Anemia, kidney disease, kidney toxicity when abuse for a long time.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Effehassan 250 mg contraindicated in the following cases:

Hypersensitivity to paracetamol or any ingredient of the drug.

Patients with glucose-6-phosphate dehydrogenase deficiency.

Be cautious when using

paracetamol is relatively non -toxic to the dose of treatment.

Must use paracetamol carefully in patients with anemia before, because purple blue may not manifest clearly although there are dangerous high concentrations of methemoglobin in the blood.

Drinking plenty of alcohol can cause toxicity to the liver of paracetamol, should avoid or limit drinking alcohol.

Use carefully with patients with impaired liver or kidney function.

Do not use paracetamol to treat pain for more than 10 days in adults or more than 5 days in children unless the physician instructs, because a lot of pain and prolonged pain may be a sign of a pathological condition that needs a physician to diagnose and supervise.

Do not use paracetamol for adults and children to treat high fever by themselves (above 39.5 ° C), fever lasts for more than 3 days or a recurrent fever, unless it is instructed by a physician, because such a fever may be a sign of a severe disease that needs to be diagnosed quickly by a physician.

To minimize the risk of overdose, do not give children more than 5 doses of paracetamol to reduce pain or reduce fever within 24 hours, unless the physician is instructed.

Doctors need to warn patients on signs of serious skin reactions such as Stevenjohnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustular syndrome (AGEP).

The ability to drive and operate machinery

The drug does not affect the ability to drive train and operate machinery.

Pregnancy

has not determined the safety of paracetamol used during pregnancy related to unwanted effects that may be available to the development of the fetus. Therefore, Paracetamol should only be used in pregnant people when really necessary.

The period of breastfeeding

Research in mothers using paracetamol during breastfeeding does not see unwanted effects in breastfeeding.

Drug interaction

Long -term oral high -dose Paracetamol takes slightly anticoagulant effects of COMAARIN and indandion derivatives.

Simultaneous use of paracetamol with phenothiazine and cooling therapy causing serious antipyretic.

Out of alcohol too much and long may increase the risk of paracetamol toxic to the liver.

Anti -seizure drugs (phenytoin, barbiturat, carbamazepin), isoniazid may increase the toxicity of paracetamol on the liver.

Storage

in a dry place, less than 30 ° C, avoid moisture.

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