Effervescent vitamin C 1g stella treatment for scorbut disease (4 blisters x 4 tablets)

Dosage form Box of 4 blisters x 4 tablets
Specifications Vitamin C

Ingredient

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Composition information	Content
Vitamin C	1g

Uses

Indications

Vitamin C Stella 1 g drug is indicated in the following cases:

Treatment Scorbut

Provide vitamin C in some special cases such as: errors in the development of teeth and bones, gingivitis, gum bleeding and long teeth. Fever, frequent illness and infection ( pneumonia , pertussis, tuberculosis, leukemia, sinusitis , rheumatoid fever, ...) increases the demand for vitamin C.

Pharmacokological

Ascorbic acid and calcium ascorbat, sodium ascorbat are the main forms of vitamin C. The human body does not produce vitamin C for themselves, but must be taken from food sources. Vitamin C is a water -soluble vitamin, necessary to synthesize collagen and components of connective tissue.

Deficiency of vitamin C occurs when food provides incomplete amount of vitamin C needed, leading to Scorbut.

Ascorbic acid has the ability to reduce in many oxidation - reduction biological reactions. There are some biological functions of ascorbic acid that has been clearly defined by Inso, including collagen, carnitin, catecholamine, tyrosin, corticosteroid and aldosterone. Ascorbic acid has also participated as a reducing agent in the drug metabolic enzyme system along with Cytochrom P450. The activity of this drug metabolic enzyme system will be reduced without ascorbic acid. Ascorbic acid also regulates absorption, transportation and reserves of iron.

Ascorbic acid is an effective antioxidant protection. Acid to Ascorbic immediately removes oxygen, reaction nitrogen (ROS = ROCTIVE Oxygen Species and RNS = Reactive Nitrogen Special) 5019) such as hydroxyl, peroxyl, superoxide, peroxynitrit and nitroxyd, free oxygen and hypocloride, which are toxic to the body.

In vitro, ascorbic acid has shown to prevent LDL oxidation by removing ROS and RNS in water, oxidation LDL is thought to cause atherosclerosis.

pharmacokinetics

absorption:

Vitamin C is easily absorbed after drinking; However, absorption is a positive process and may be limited after huge doses. Provide regular amount of vitamin C through diets from 30 - 180 mg daily, about 70 - 90% absorbed.

At the daily dose per daily, the absorption decreases to about 50% or less. In normal human research, only 50% of a dose of 1.5 g vitamin C is absorbed. Absorption of vitamin C in the stomach - intestines can be reduced in the diarrhea or gastric disease.

Normal vitamin C concentration in plasma is about 10 - 20 micrograms/ml. Plasma concentrations below 1 - 1.5 micrograms/ml when scorbut disease.

The total amount of vitamin C reserves in the body is estimated at about 1.5 g with about 30 - 45 mg daily rotation. Clinical signs of Scorbut disease often become clear after 3-5 months of vitamin C deficiency.

Distribution:

Vitamin C is widely distributed in body tissues. High vitamin C levels are found in the liver, leukocytes, platelets, gland tissue and lens of the eye. About 25% of vitamin C in plasma combined with protein.

Ascorbic acid passes through the placenta and distributed in breast milk.

Era:

Acal acid ascorbic oxidizes reversible into dehydrooscorbic acid. A little vitamin C converted into non-activity compounds including ascorbic acid-2-sulfate and oxalic acid excreted in urine.

There is an abnormal excretion threshold through the kidneys about 14 micrograms/ ml, this threshold may vary depending on each person. When the body saturated ascorbic acid and blood concentration beyond the threshold, ascorbic acid is unchanged and eliminated into the urine.

This is the basis for ascorbic acid saturated test for vitamin C nutrition.

When saturated in tissue and ascorbic acid levels in low blood, ascorbic acid eliminates less or not excreted into the urine. Ascorbic acid can be removed by hemolysis.

Before taking Effervescent vitamin C 1g stella treatment for scorbut disease (4 blisters x 4 tablets)

How to use

use by oral. Dissolve the pill in a glass of water.

Dosage

Adults: 1 tablet/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Diuretic by infusion may work after a large dose.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Vitamin C Stella 1 g, you may experience unwanted effects (ADR): Increased oxalate urinary tract, nausea, vomiting, heartburn, abdominal spasms, fatigue, redness, headache, insomnia, and drowsiness occurred. After taking 1 g daily or larger, diarrhea may occur.

Common, ADR> 1/100

Kidney: increased oxalate urine.

Uncommon, 1/1000

Blood: Anemia hemolytic;

Cardiovascular: flushed, heart failure ;

Central nervous system: faint, dizziness, headache, fatigue; stomach - intestines: nausea, vomiting, heartburn, diarrhea;

Neurological - muscle and bone: pain edge.

Instructions on how to handle ADR

Do not stop suddenly after using high doses of vitamin C for a long time to prevent the recovery scorbut due to the induction of the metabolism of vitamin C, as it is a physiological response and the consequence of the previous high doses of vitamin C.

Warnings

Before using Vitamin C Stella 1 g you need to read the user manual carefully and refer to the information below.

contraindicated

Vitamin C Stella 1 g drug is contraindicated in the following cases:

Hypersensitivity to vitamin C or any ingredient of the drug.

Avoid high doses of vitamin C for patients:

Glucose deficiency - 6 - Phosphate dehydrogenase (risk of hemolytic hemolytic deficiency).

Be cautious when used

Taking high doses of vitamin C can lead to metabolism of the drug ("greasy phenomenon"), when reduced to normal dose can cause scorbut disease. High doses of vitamin C during pregnancy can lead to scorbut disease for babies.

Hemolysis can occur when using vitamin C for babies with glucose deficiency - 6 - phosphate dehydrogenase and other healthy babies.

Increase oxalate can occur after high doses of vitamin C. Vitamin C can cause urine acidification, sometimes leading to urate, cystin, or oxalate stones, or medications in urinary tract.

Vitamin C Stella 1 G contains aspartam. Aspartam is a source of phenylalanin, which can be harmful to patients with phenylketonuria (PKU), a rare genetic disorder causing phenylalanin accumulation because the body cannot be appropriately eliminated.

The ability to drive and operate machinery

does not affect.

Pregnancy

Vitamin C passes through the placenta. There are no studies on animals and on pregnant people, if vitamin C is used according to normal needs 80 daily, there is no problem on people. However, taking large amounts of vitamin C during pregnancy can increase the need for vitamin C and lead to scorbut disease in infants.

breastfeeding period

vitamin C distributed in breast milk. Breastfeeding people use vitamin C according to normal needs have not seen any problems that occur for babies.

Medicinal interaction

simultaneously used in the ratio of over 200 mg of vitamin C with 30 mg of elemental iron to increase the absorption of iron through the stomach - intestines; However, most patients have the ability to absorb iron to drink fully without having to use Vitamin C simultaneously.

Simultaneous use of vitamin C with aspirin increases the secretion of vitamin C and reduces aspirin secretion through urine.

Simultaneous use of vitamin C and fluuphenazin leads to a decrease in Fluphenazin level plasma. The acidification of urine after using vitamin C can change the excretion of other drugs. The high -dose vitamin C family can destroy vitamin B12, which should be advised to avoid taking high doses of vitamin C within an hour before or after taking vitamin B12.

Vitamin C is a powerful reducing agent, which affects many tests based on redox reactions. The presence of vitamin C in urine increases the amount of glucose if quantitative with copper reagent (II) sulfate and false reduction of glucose amount if quantitative by glucose oxidase method.

Storage

Store in closed packaging, dry in, avoid light and avoid moisture. The temperature does not exceed 30 ° C.

To be out of reach of children.

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