Eftifarene pharmacy 3-2 supports stable angina treatment (2 blisters x 30 tablets)

Dosage form Box of 2 blisters x 30 tablets
Specifications Trimetazidine

Ingredient

Composition information	Content
Trimetazidine	20mg

Uses

indications

Eftifarene 20mg drugs are indicated in the following cases:

Indications for adults in supplementary therapy/support for existing treatment to treat symptoms in patients with stable angina unproving or adequate patients with non -tolerated patients with other angina therapy.

Pharmacology

trimetazidin inhibits the oxidation of fatty acids by inhibiting the dragon-chain enzymes 3 ketoacel-coa thiolase in ischemic cells, energy obtained during oxidation of glucose needs to consume less than oxidation.

Promoting glucose oxidation will help optimize cell energy processes, thus maintaining appropriate energy metabolism during anemia.

In patients with ischemic anemia, trimetazidine acts as a metabolite, which helps conserve high intra -intra -intra -intra -intra -intra -intracellular energy levels in myocardial cell. Trimetazidin has anti -anemia effect but does not affect hemodynamics.

pharmacokinetics

trimetazidin when taken is absorbed very quickly and reaches the peak concentration in plasma before 2 hours from drinking.

The maximum concentration of the drug in plasma after taking a single dose trimetazidin 20 mg, reaching about 55 ng/ml.

The equilibrium of the drug in the blood is reached from 24 to 36 hours after being repeated 1 dose and very stable during treatment.

The integral distribution of 4.8 liters/kg shows the good diffusion level of the drug to the tissues. Low protein attachment ratio, measured value in vitro is 16%.

half -life of trimetazidine is 6 hours. The drug is excreted mainly in urine in the form of unprovered.

Before taking Eftifarene pharmacy 3-2 supports stable angina treatment (2 blisters x 30 tablets)

How to use

Eftifarene 20mg oral oral medication in the morning and evening with meals.

Dosage

Common dose: one tablet 20mg/ time x 3 times/ day.

Special subjects:

Patients with average renal impairment (clearine clearance 30 - 60 ml/minute):

20 mg tablet form: recommended dose is 1 tablet 20mg/time x 2 times/day, morning and evening with meals (see more contraindications, warnings and caution).

Elderly patients may have a higher level of trimetazidin sensitivity than normal due to age -down impaired impairment.

20 mg tablets for patients with average renal failure (Creatinine clearance 30 - 60 ml/ minute): recommended dose is 1 tablet 20 mg/ time x 2 times/ day, morning and evening use with meals (see more contraindications, warning and cautious parts).

should be cautious when calculating the dose for elderly patients (see more contraindications, warnings and caution).

Children:

The safety and effectiveness of trimetazidine for patients under 18 years of age has not been evaluated.

There is currently no data on this patient object. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using EFTifarene 20mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Nervous system disorders: dizziness, headache.

Disorders on the stomach - intestines: abdominal pain, diarrhea, indigestion, nausea and vomiting.

Disorders on skin and subcutaneous tissue: Rashes, urticaria.

Systemic disorders and drug use: weakness.

rarely, 1/1000

No report.

rare, 1/10000 ≤ ADR

Disorders on the heart: Brushing chest drum, nervousness, extra mind, fast heartbeat.

Disorders on vessels: arterial hypotension, vertical hypotension, which can lead to discomfort, dizziness or falling, especially in patients being treated with anti -hypertension drugs, flushing.

Unknown frequency

Nervous system disorders: Parkinson's symptoms (slow and difficult and difficult movement, muscle tone), unstable gait, vacuum syndrome, other relevant movement disorders, can often recover after stopping the drug; Sleep disorders (insomnia, drowsiness).

Stomach - intestinal disorders: constipation.

Disorders on the skin and subcutaneous tissue: External pustules (AGEP), Evaluation.

Disorders of blood systems and lymphatic systems: granulocytosis, thrombocytopenia, thrombocytopenic decline.

Liver disorders: Hepatic failure.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Eftifarene 20mg contraindications in the following cases:

Hypersensitivity to the active ingredient or any excipient is listed in the product preparation formula.

Parkinson patient, Parkinson's symptoms, tremor, vacuum syndrome and other relevant movement disorders.

Severe renal failure (creatinine clearance

Caution when using

trimetazidin can cause or worsen Parkinson's symptoms (Run, slow movement and difficulty, increase muscle tone), so patients, especially elderly patients, need regular inspection and monitoring. In suspicious cases, patients need to be taken to a neurologist for appropriate examination.

When encountering movement disorders such as Parkinson's symptoms, irritability, tremor, unsteady gaits immediately stop using trimetazidin.

These cases occur and often recover after stopping the drug. Most patients recover after stopping the drug for about 4 months. If Parkinson's symptoms continue to happen for more than 4 months after taking the drug, consulting neurologists.

may have an expression of ego, unstable gait or hypotension, especially in patients who are taking drugs to treat hypertension (see more unwanted effects).

Be careful when prescribing trimetazidin for patients with high sensitivity levels such as (see more dose and usage):

Patients with average renal failure.

Patients over 75 years old.

The ability to drive and operate machinery

trimetazidin can cause symptoms such as dizziness and drowsiness, so it can affect the ability to drive and operate machinery.

The best pregnancy

does not use trimetazidin during pregnancy.

Breastfeeding period

Do not breastfeed during trimetazidin treatment.

Notify the doctor any unwanted effects related to the medication.

Interactive drug

currently has no interaction with any drug. Trimetazidin is not an induction drug nor is a drug inhibiting the liver metabolic enzyme in the liver and thus is more likely to trimetazidin does not interact with many metabolic drugs in the liver.

Still carefully monitoring when coordinating with some other drugs.

Storage

Leave a cool dry place, temperatures below 30 ° C, avoid light.

Other drugs

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