Emanera 20mg Krka medicine for gastroesophageal reflux disease (4 blisters x 7 tablets)

Dosage form Box of 4 blisters x 7 tablets
Specifications Esomeprazole

Ingredient

Composition information	Content
Esomeprazole	20mg

Uses

indications

Emanera drugs are indicated in the following cases:

adolescents over 12 years old

Gastroesophageal reflux disease (GERD)

Treatment of esophageal ulcerative ulcer.

Adults

Gastroesophageal reflux disease (GERD)

Treatment of esophageal ulcerative ulcer.

Heals gastric and duodenal ulcers caused by Helicobacter pylori.

Prevention of ulcers in patients who are using NSAID or patients at risk.

Zollinger - Ellison syndrome and other cases are accompanied by increased stomach acid secretion.

Prolonged treatment after treatment for hemorrhage due to intravenous peptic ulcer.

Pharmacokology

Esomeprazol is attached to H+/K+-Aatpase (also known as proton pump) in the walls of the stomach wall, inactivating this enzyme system, preventing the final step of the excretion of hydrochloric acid secretion into the stomach heart.

Dynamic pharmacokinetics

Esomeprazol absorbed quickly after oral, reaching the highest concentration in plasma after 1-2 hours. Esomeprazol's bioavailability increases according to the dose and when used to repeat, reaching about 68% when taking the dose of 20 mg and 89% when taking the dose of 40 mg.

Food slows the ability to absorb Esomeprazol, but does not change the effect of the effect of the drug on the acidity in the stomach. About 97% Esomeprazol attaches to plasma proteins. The drug is metabolized mainly in the liver thanks to the Cytochrom P450 enzyme system, the isenzyme CYP2C19. Selling time is about 1.3 hours.

Before taking Emanera 20mg Krka medicine for gastroesophageal reflux disease (4 blisters x 7 tablets)

How to use

Take medicine at any time of the day.

Can be taken before or after eating.

Swallow the tablet with water, do not chew or crush before drinking.

Dosage

Adults and children over 12 years old

Gastroesophageal reflux disease

Treatment of esophagitis due to reflux: 40 mg daily for 4 weeks. Can be used for 4 more weeks for patients who still have inflammation.

Treatment is maintained after gustary inflammation: 20 mg daily.

Treatment of symptoms of gastroesophageal reflux disease: 20 mg per day (if the patient does not have esophagitis due to reflux) about 4 weeks.

Treatment in combination with Helicobacter Pylori antibiotics

20 mg of Emanera combined with 1 g amoxicillin and 500 mg Clarithromycin, 2 times a day within 7 days.

For patients who are using NSAID

Treatment of stomach ulcers due to the use of anti -inflammatory drugs NSAID: 20 mg daily, within 4 to 8 weeks.

Preventive prevention of stomach ulcers in people with high risk of stomach - duodenal complications, but there is a requirement to continue treatment with nonsteroidal anti -inflammatory drugs: 20 mg daily.

Treatment of Zollinger Ellison syndrome

The recommended starting dose is Emanera 40 mg, twice a day. Then adjust according to the response of each patient and continue treatment when clinically indicated.

Person of kidney function

No need to adjust the dose in patients with renal function damage. Due to the experience of using drugs in patients with kidney damage, it is limited, so it must be cautious.

Liver function damage

No need to reduce the dose in people with mild to moderate liver function damage, in patients with severe liver failure, do not overdose up to 20 mg of Esomeprazol.

Elderly

No dose adjustment in the elderly.

Children under 12 years old

There is no research data when using Emanera for children under 12 years old.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Emanera, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Nervous system disorders: headache.

gastrointestinal disorders: abdominal pain, constipation, diarrhea, bloating, nausea/vomiting ...

Uncommon, 1/1000

Metabolic and nutrient disorders: peripheral edema.

Mental disorders: Insomnia.

Nervous system disorders: dizziness, paresthesia, chicken sleep.

Digestive disorders: dry mouth.

Rare, 1/10000

Blood disorders and lymphatic systems: leukopenia, thrombocytopenia.

Immune system disorders: Hypersensitivity reactions such as fever, angioedema, anaphylactic/anaphylactic reaction.

Disorders of metabolism and nutrition: Hemati sodium.

Mental disorders: agitation, confusion, depression ...

Nervous system disorders: taste disorders.

Gastrointestinal disorders: stomatitis, gastrointestinal candidiasis.

Very rare, ADR

Blood disorders and lymphatic systems: granulocytosis, reducing all bloody platelets.

Disorders of metabolic and nutrition: reduces blood magnesium; Heavy reduction may be associated with hypocalcemia; Lose magnesia blood can also lead to hypokalemia.

Mental disorders: impatient, hallucinations.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

EMANERA drug contraindicated in the following cases:

Hypersensitivity to Esomeprazole, Benzimidazole or any ingredient of the drug.

Be cautious when using

when there is any alarm symptom (such as significant weight loss, recurrent vomiting, difficulty swallowing, vomiting of blood or black stools) and when suspected stomach ulcers or stomach ulcers, should eliminate malignant diseases because treatment with Emanera can mitigate symptoms and delay the diagnosis of the diagnosis.

Patients with long -term treatment (especially those who have been treated for more than 1 year) should be monitored regularly.

Patients treated when necessary (on-demand treatment) Contact your doctor if there are changes in the properties of symptoms. When prescribing Esomeprazol in the treatment mode when necessary, it is advisable to consider interaction associated with other drugs due to the change in the plasma Esomeprazol level.

When prescribing Esomeprazol to eliminate Helicobacter pylori, drug interactions should be considered in the 3 -drug treatment regimen.

This drug contains sucrose. Patients with rare genetic problems such as fructose intolerance, malventa-galactose absorption or deficiency of sucrase-isomtase should not be taken.

Proton pump inhibitors may increase the risk of gastrointestinal tract infections caused by Salmonella and Campylobacter.

It is not recommended to simultaneously use Esomeprazole with Atazanavir.

Esomeprazole, as well as other antacids, can reduce the absorption of vitamin B12 (cyanocobalamin) due to a reduction or lack of gastric acid.

There have been reports on severe blood magnesium reduction in patients treated with proton pump inhibitors (PPI) such as Esomeprazole for at least 3 months, and in most cases, they often start silently and are not concerned.

Proton pump inhibitors, especially when taking high doses and for a long time (> 1 year), may increase the risk of thigh, wrist and spinal bone fractures, especially in elderly patients or when there is a presence of other risk factors.

The ability to drive and operate machines

Emanera does not affect driving and operating machinery.

Pregnancy

should be cautious when prescribing pregnant women.

Breastfeeding period

should not use Emanera during breastfeeding.

Interactive drug

like other drugs that reduce other stomach acid, the absorption of drugs such as ketoconazol, iTraconazole and erlotinib may decrease and the absorption of digoxin may increase during treatment with ecomeprazol.

There is a report that Omeprazol interacts with some protease inhibitors.

Therefore, when Esomeprazol is used with metabolic drugs with CYP2C19 such as diazepam, citalopram, imipramin, clomipramin, phenytoin ..., the concentration of these drugs in plasma can increase and need to reduce the dose.

When concurrent use Esomeprazol with a CYP3A4 inhibitor, Clarithromycin (500 mg, 2 times/day) doubled the area under the curve (AUC) of Esomeprazol.

Storage

Storage in packaging, cool dry places, avoid light, temperature below 30 ° C.

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