ENAPLUS HCT Stellapharm treatments for mild hypertension to medium (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Enalapril, hydrochlorothiazid

Ingredient

Composition informationContent
Enalapril10mg
Hydrochlorothiazid12.5mg

Uses

Indications

Treatment of mild hypertension to fit patients who have stabilized blood pressure when using individual ingredients with the same ratio.

Pharmacokology

Enalapril Maleatate

Angiotensin (ACE) enzyme (ACE) is a peptidyl dipeptidase that catalyzes Angiotensin I into angiotensin II to have vasoconstrictor effect.

Enalapril causes hypotension mainly through inhibition of the renin-angiotensin-aldosterone system, the system plays a major role in regulating body blood pressure. Enalapril hypotension even in hypertension patients with low renin.

Enalapril Maleate - Hydrochlorothiazide

Hydrochlorothiazide is a diuretic and hypotension that increases the activity of plasma renin. Enalapril has the ability to lower blood pressure on both hypertension patients with low renin, simultaneous use of enalapril with hydrochlorothiazide in these patients leading to stronger hypotension.

pharmacokinetics

No data.

Before taking ENAPLUS HCT Stellapharm treatments for mild hypertension to medium (3 blisters x 10 tablets)

How to use

enaplus hCT 10/12.5 Used orally.

Dosage

  • The usual dose of Enalapril is 10 - 40 mg/day, the only dose or divided into 2 doses; The effective dose of hydrochlorothiazide is 12.5 - 50 mg/day. To minimize unwanted effects do not depend on the dose, should only start combining treatment after the patient does not achieve the desired effect with the monotherapy. Hydrochlorothiazide dose should be maintained 2-3 weeks before increasing. Normally, do not use more than 20 mg of enalapril or more than 50 mg of hydrochlorothiazide. Mg/DL or 265 µmol/l). In patients with worse renal failure, recommend the use of diuretics than thiazide diuretics, so it is not recommended to use the combination of Enalapril Maleatate and Hydrochlorothiazide.

    What to do when forgetting a dose?

    • Side Effects

    Very common

  • blurred vision;
  • dizziness;
  • Hypotension, cholesterol hyperkemen, hyper triglyceride, hyperuricemia; Hypotension, hypotension, arrhythmia, angina, Heart rate;
  • Difficulty; Thanh.

    • Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    contraindicated

  • Hypersensitivity to the active ingredients or any ingredients of the drug. sulfonamide.
  • Pregnant women in the second and third quarter of pregnancy.

    Be cautious when using

    enalapril maleate - Hydrochlorothiazide

    Hypotension and electrolyte imbalance

  • In patients with hypertension using Enaplus HCT 10/12.5, it is easy to tend to have symptoms of hypotension if the patient has a decrease in the volume of circulatory.

    Renal function impairment

    Renal failure is reported related to enalapril and is common in patients with severe or kidney disease.

    Renin-Anotensin-Aldosterone (RAA)

    There is evidence that the simultaneous use of ACE inhibitors, Angiotensin II receptor blockers or Aliskiren increases the risk of hypotension, hyperkalemia and impaired kidney function.

    Hyperbonia

    The combination of enalapril and low -dose diuretics does not rule out the possibility of increased potassium.

    lithium
    does not recommend combining lithium with enalapril and diuretics.

    lactose

    Patients with rare genetic problems in terms of galactose tolerance, total lactase enzyme deficiency or poor absorption of glucose-galactose should not use this drug.

    Enalapril Maleatate

    Aortic narrow/myocardial hypertrophy

    Be careful to use ACE inhibitors for patients with valve obstruction and output of left ventricular ventricular and avoid use in case of heart shock and significant hemodynamic obstruction.

    Renal function impairment

    There has been a report on renal failure when taking enalapril in patients with severe heart failure or kidney disease.

    Hypertension due to kidney vessels

    The risk of lowering blood pressure and renal failure when treating with a ACE inhibitors is higher for patients with patients with kidney stenosis on both sides or one side for patients with only one kidney. Loss of kidney function can occur with only small changes in serum creatinine.

    Patients with hemolysis

    Enalapril is not indicated for patients with kidney failure to hemogle.

    Renal transplant

    Do not recommend using enalapril for kidney transplants.

    Hepatic failure

    Rarely treat ACE inhibitors causes jaundice syndrome or hepatitis and progress to liver necrosis and (sometimes) leading to death.

    Neutral leukemia/grain leukemia

    Neutral leukemia, grain leukemia, thrombocytopenia and anemia have been reported in patients treated with ACE inhibitors.

    Hyperbonia

    Hyetamic hyperboly is reported in some patients treated with ACE inhibitors, including enalapril.

    Hypoglycemia

    When starting to use ACE inhibitors for patients with diabetes treated with an oral diabetes or insulin, it must be taken to the patient how to closely monitor blood glucose, especially in the first month when starting to use.

    Hypersensitivity/Neurological fleet

  • edema on the face, limbs, lips, tongue, subjects and/or larynx have been reported in patients treated with ACE inhibitors, including Enalapril. Suffering.

    • Anaphylactic reaction in the process of hypersensitivity to Hymenoptera

    Rarely patients using ACE inhibitors with anaphylactic reaction are life -threatening while treating hypersensitivity to Hymenopter venom.

    Anaphylactic reaction during the LDL classification process

    Some patients who use ACE inhibitors in the process of classifying LDL with Dextran Sulfate may occur a life -threatening reaction to life, although these cases rarely occur.

    ho

    cough has been recorded when using ACE inhibitors. Typically, dry cough, prolonged and will end when stopping the drug.

    surgery/anesthesia

    In patients undergoing surgery or during anesthesia with drugs that cause hypotension, Enalapril prevents the formation of angiotensin II and thus reduces the ability to compensate through the renin-anidensin system.

    pregnancy

    Do not start treatment with ACE inhibitors during pregnancy.

    racial difference

    As other ACE inhibitors, Enalapril is obviously less effective in reducing blood pressure on black people than other races, possibly due to a low rules in the ratio of hypertension.

    hydrochlorothiazide

    Renal function impairment

    Thiazide diuretics may not be suitable for patients with renal impairment and ineffective when creatinine clearance ≤ 30 ml/min (medium or severe kidney failure).

    Liver disease

    Thiazide should be used carefully in patients with impaired liver function or progressive liver disease, because small changes in body fluid and electrolyte balance are likely to lead to liver coma.

    impact on metabolism and endocrine

  • Thiazide can reduce glucose tolerance. It may be necessary to adjust the dose of diabetes to treat diabetes, including insulin. Thiazide will probably reduce the concentration of sodium, magnesi and potassium serum. Know. This impact may be related to the dose. In addition, Enalapril can increase uric acid in the urine and therefore can reduce the effect of increasing blood uric acid of hydrochlorothiazide. and electrolytes (hypotension, sodium hypoglycemia, and alkaline infection due to hypoglycemia). Can increase the secretion of magnesium through the urine, leading to lowering blood.

    • Anti -doping test
    hydrochlorothiazide can give positive analysis results in anti -doping tests.

    hypersensitivity

    Hypersensitivity can occur in patients treated with Thiazide, whether patients with or without a history of allergies and bronchial asthma. There have been reports when using thiazide diuretics that seriously or activated the system lupus erythematosus.

    The effect of the drug on the ability to drive and operate machinery

    When driving or operating machines, pay attention to the ability to sometimes be dizzy, tired.

    Use drugs for women during pregnancy and lactation

    No data.

    Drug interaction

    drug interactions can affect the activity of the drug or cause side effects.

    Patients should notify the doctor or pharmacist a list of the drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

    Storage

    Leave a cool place, avoid light, temperatures below 30⁰C.

    To be out of reach of children, read the instructions carefully before use.

    Other drugs

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