ENVIX 6 Meyer - BPC treatment for worms only onchocerca, e -worm in the intestine (2 blisters x 2 tablets)

Dosage form Box of 2 blisters x 2 tablets
Specifications Ivermectin

Ingredient

Composition information	Content
Ivermectin	6mg

Uses

indications

Envix 6 drugs are indicated in the following cases:

Treatment of worms only onchocerca due to worm larvae only onchocerca volvulus. The group of substances has a large lacton structure, isolated from the streptomyces Avermitilis fermentation. Ivermectin has a broad spectrum on roundworms and secretions of cattle, thus being used in veterinary.

The first drug was used for humans in 1981. Ivermectin is effective on a variety of round worms such as eelworms, hair worms, needle worms, roundworms, hookworms and Wuchereria bancrofti. However, the drug does not work on liver fluke and tapeworms. The drug has anti -worm larvae with only onchocercca volvulus and reduces the number of worm larvae that are not toxic as when using diethylcarbamazin. Ivermectin also has the effect of anti -worm larvae in white vessels and is used to treat the community in the circulating diseases. After treatment usually has to be treated after a period of at least 3 months. For community treatment, annual dosage or 6 months.

Currently, Ivermectin is a chosen drug to treat worms only onchocerca Volvulus and is a worm larvae that is only very strong, but has little effect on mature parasites. After drinking for 2-3 days, the worm larvae only go away quickly; The larvae in the cornea and eye room are slower. The maximum effect of treating worms only onchocerca is from 3-6 months and in the treatment of Strongyloides (Ecbis) is 3 months.

The effect of the drug may last up to 12 months. One month after use, the larvae at the uterus only mature unable to escape, and then degenerated and eliminated. The effect of prolonged larvae is very helpful in preventing the spread of the disease.

Mechanism of action: Selective and affinity drugs with chloride channels glutamate are found on nerve cells and muscles of non -vertebrates, leading to an increase in the permeability of cell membranes for chloride ions and then neglect the voltage of these cells, leading to paralysis and death of parasites.

Dynamic pharmacokinetics

Ivermectin is absorbed after oral, still unknown the absolute use of the drug after taken. In general, there is no difference in the peak concentration of plasma between tablets and capsules (46 compared to 50 micrograms/liter). However, when using ivectin with alcoholic beverages such as beer, alcohol, the peak concentration doubled and the relative bioavailability of the tablet is only 60% of the bioavailability of the solution. Birth increases in fat -rich meals. The time reaches the peak concentration in plasma for about 4 hours and is not different between the forms of preparation.

Ivermectin has an integral distribution of 3 - 3.5 liters/kg, not through the brain blood barrier. Half life eliminated at about 18 hours. About 93% of the drug is linked to plasma proteins. Metabolic drugs in the liver, mainly through Cytochrom P450 ISOENZYM CYP3A4.

The drug is eliminated in the form of metabolism for about 2 weeks, mainly through feces, less than 1% of the dose is discharged through urine and less than 2% in milk.

Before taking ENVIX 6 Meyer - BPC treatment for worms only onchocerca, e -worm in the intestine (2 blisters x 2 tablets)

How to use

oral tablets. Take the tablet with a glass of water.

Dosage

Dosage in case of treatment:

Adults and children weighs 15 kg or more and over 5 years old:

Worm disease is only onchocerca: using a single dose of 0.15 mg/kg. Higher doses will increase the harmful reactions, without increasing the effectiveness of treatment. It is necessary to re -treat the same dose as above 3 - 12 months until there are no more symptoms. Other dose: 0.2 mg/kg/day, for 2 days. Only 0.2 mg/kg.

Dosage as prescribed: 0.15 mg/kg

weight (kg)

15 - 25

3 mg

26 - 44

6 mg

45 - 64

9 mg

65 - 84

12 mg

≥ 85

0.15 mg/kg

weight (kg)

15 - 24

3 mg

25 - 35

6 mg

36 - 50

9 mg

51 - 65

12 mg

66 - 79

15 mg

≥ 80

0.2 mg/kg

Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

The main manifestations of Ivermectin poisoning are skin rash, edema, headache, dizziness, dizziness, weakness, nausea, vomiting, diarrhea.

When being poisoned, it is necessary to infusion and electrolytes, respiratory aids (oxygen and artificial respiration if needed), use hypertension if there is hypotension. Dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

Ivermectin is a safe drug, very suitable for broad treatment programs. Most of the ADRs of the drug are caused by immune reactions to dead larvae. Therefore, the severity of ADR is associated with skin larvae density. The ADR has been notified including fever, itching, dizziness, edema, skin rash, sensitive pain in lymph nodes, sweating, shivering, muscle pain, swelling of joints, swelling of the face (Mazzotti reaction), sore throat, cough, headache. Hypoglycemic hypotension has been notified with sweating, tachycardia and confusion.

Ivermectin may cause eye irritation at an average level. Incretion increases and increased liver enzymes have been reported.

ADR usually occurs in the first 3 days after treatment and depends on the dose. The proportion of ADR has been notified very different.

Here is ADR in the treatment of worms only onchocerca dose 0.1 - 0.2 mg/kg:

Common, 1/100 ≤ ADR Osteoarthritis: joint pain/epidemic inflammation (9.3%). Skin reactions such as edema, nodules, pustules, skin rash, urticaria (22.7%). Peripheral (3.2%). (0.4%).

Ivermectin can cause skin reactions and body reactions to different levels (Mazzotti reaction) and eye reactions in patients with worms only onchocerca. These reactions may be the result of allergies and inflammation caused by dead larvae.

can treat these reactions by taking analgesics, antihistamine or corticosteroid injection as soon as the symptoms appear. Dosage depending on the degree of the reaction.

When hypotension is vertical, oral, lying, lying, intravenous salt water or corticosteroid injection. It should be remembered that iVERMECTIN does not kill the adult onchocerca parasites, thus regularly monitoring and re -treatment is necessary. Must instruct the patient.

Notify the physician with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

ENVIX 6 contraindications in the following cases:

Hypersensitivity to Ivermectin and any ingredients of the drug.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Severe or death brain disease occurred in patients after taking Ivermectin to treat onchocerca infection in the area with worms indicating the speaker circulating (due to the larvae in the blood). More. The drug increases GABA, so there should be the idea that the drug has the effect on the central nervous system in humans where the brain barrier is damaged (such as in meningitis, trypanosoma disease). up.

The effect of the drug on driving and operating machinery

The drug does not affect the ability to drive and operate machinery.

Using drugs for women during pregnancy

pregnancy

The monster effect has been monitored on research animals. Because there is no study controlled on pregnant women, Ivermectin is not recommended for pregnant women.

Breastfeeding period

Ivermectin secretes breast milk with low concentrations (less than 2% of the drug used). Safety for babies has not been determined, so only this medication is used for the mother when the benefit of the mother is superior to the risk of the baby. Do not give the mother medicine until the child is at least 1 week of age.

Interactive drug

Theoretically, the drug can increase the effect of GABA receptors stimulants (such as benzodiazepine and sodium valproot). Increasing when using simultaneously with azithromycin, P-Glycoprotein/ABCB1 inhibitors.

Tuong Tuong

due to no studies on the correspondence of the drug, not mixing this drug with other drugs.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

Other drugs

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