Epalrest 50mg Pharma prevent and treat diabetes complications (2 blisters x 14 tablets)

Dosage form Box of 2 blisters x 14 tablets
Specifications Epalrestat

Ingredient

Composition information	Content
Epalrestat	50mg

Uses

Indications

Epalrest 50mg drug is indicated in the following cases:

Prevent and treat diabetes neuropathy. Polypol. Under normal sugar conditions, most cell glucose is phosphoryl turned into glucose-6-phosphate by enzyme hexokinase. About 3% of non -phosphoryl metabolized phosphoryl metabolized according to the polyol process into sorbitol by eliminating aldose in the presence of nicotinamieadenosine dinucleoside phosphate (NADPH). Sorbitol was then converted into fructose by the enzyme sorbitol dehydrogenase with the simultaneous participation of the oxidation of Nicotinamide Adenine Dinucleotide (NAD). In high road conditions, the polyol process is increased and accounts for over 30% of glucose metabolism.

Studies show that the enhancement of polyol processes causes a chain of metabolic imbalance can increase diabetic vascular complications such as neuropathy, eye and kidney disease, as well as large vascular complications including myocardial and stroke infarction.

The increase in sugar and increase the reducing activity of Aldose causes sorbitol accumulation and increases cell permeability, causing Myoinositol deficiency. Thereby reducing the activity of Sodium-Potassium Adenosine Triphosphate and changes cell metabolism and membrane structure. Oxidation-dehydration imbalance occurs due to an increase in NADPH ratio: NAD+ can activate protein kinase C and form active oxygen roots and hygienic products. The activation of protein kinase C increases the surface manifestation of endothelial molecules, thereby increasing atherosclerosis.

Aldose reducing enzyme inhibitors can overcome metabolic disorders associated with polyol processes and pathology of diabetes complications.

pharmacokinetics

According to the instructions for use licensed for Epalrestat, the maximum concentration in plasma is 3.9µg/ml placed after taking the dose of 50mg after eating in healthy people, the area of the concentration - time curve (AUC) is 6.4µg/hour/mL. The metabolism of the drug occurs in the liver according to phase 1 and 2.

reactions.

During phase 1 metabolism, epalrestat is converted by hydroxylation process into two metabolic products, monohydroxy and dihydroxy compounds. The enzymes are involved in metabolic by the reactions in phase 2 to create glucuronide and sulfate bonds. Original Epalrestat is not metabolized to the urine along with the sulfate combined form of 2 metabolic products. Epalrestat has a high protein bond rate of 90.1%. Epalrestat pharmacokinetics have no study conducted in patients with liver or kidney failure, on diabetics or elderly patients. No drug interaction with Epalrestat has been reported.

Before taking Epalrest 50mg Pharma prevent and treat diabetes complications (2 blisters x 14 tablets)

How to use

Epalrest oral oral drugs.

Dosage

normal doses with adults 50mg/time, 3 times/day, drink before eating.

Adjustable doses depending on the condition, age. The minimum treatment time to achieve the effect of Epalrestat is 12 weeks.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

There is no reporting document.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Epalrest 50mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: liver dysfunction, nausea, vomiting, discomfort, diarrhea.

Systemic body: Floating skin, numbness, edema.

kidney: kidney dysfunction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Epalrest drug 50mg is contraindicated in the following cases: Hypersensitivity to any component of the drug.

Precautions when using

The effect of the drug has not been set in patients with peripheral neurological complications caused by diabetes, so these patients need to be monitored during the use of the drug, which can replace other appropriate treatment if the treatment effect has not been recorded after using the drug for 12 weeks.

The use of epalrestat in patients with liver or kidney failure has not been fully evaluated, but increased levels of liver enzymes may increase serum creatinine and blood urea. When using urine drugs can turn color into yellow or red, but does not affect health.

The ability to drive and operate machinery

There is no reporting document.

Pregnancy

Epalrest is not in the list of contraindications for pregnant women, but it is necessary to consider using when the treatment benefits are superior to risks that may occur for fetuses due to drug use.

Breastfeeding period

Need to avoid using the drug while breastfeeding.

Drug interaction

No drug interaction has been reported.

Storage

Storage in closed packaging, dry place, avoid light, temperature below 30 ° C.

Other drugs

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