EPEGIS AGIMEXPHARM improves symptoms of muscle tone (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Eperison

Ingredient

Composition information	Content
Eperison	50mg

Uses

indications

Epegis drug indications for treatment in the following cases:

improve the symptoms of muscle tone related to the following diseases: cervical vertebra syndrome, shoulder arthritis and waist. Other cerebrospinal physics. Eperison has a stable treatment effect in improving various symptoms related to muscle tone, thanks to cutting the pathological spiral of muscle spasms.

Eperison has the main impact on the spinal cord, reducing the marrow reflexes and creates muscle relaxation by reducing the sensitivity of the muscle through the Gamma centrifugation system.

In addition, the vasodilation effect of the drug increases circulation. Therefore, Eperison is with a diverse method, cutting off the pathological spiral, in which the muscle contraction on the disorder of blood flow, then causes pain and leads to an increase in muscle tone.

Eperison has been shown to be a clinical effect in improving the symptoms of muscle tone, such as shoulder spasms, cervical vertebra pain, muscle contraction, dizziness, lumbar pain and spasms of limb - may be accompanied by cerebrospinal disease, neck vertebra syndrome, shoulder and lumbar arthritis.

pharmacokinetic

Eperison hydrochloride has been used by oral in healthy adults at a dose of 150 mg/day, for 14 consecutive days.

On the 1st, 8th and 14th day, the average time leads to the maximum concentration range from 1.6 to 1.9 hours.

Maximum maximum concentration is 7.5 to 7.9 ng/ml; The average half -life is 1.6 to 1.8 hours and AUC (the area below the plasma concentration curve) is 19.7 to 21.1 ng.he/ml.

The plasma concentration parameters of Eperison Hydrochorid are measured on the 8th and 14th day, there is no significant change compared to the first day.

absorption, distribution, metabolism and elimination: When 14C-epison hydrochloride (Eperison hydrochloride is marked with radioactive 14C) used by oral for mice at a dose of 50 mg/kg, most of the drugs are absorbed through the gastrointestinal tract and Eperison hydrochloride concentration in the form of low bloody plasma.

This suggests that the first-pass) is relatively high. After 30 minutes after drinking, radioactive concentration in the brain, spinal cord, thigh nerves and muscles at the same amount as blood levels.

Within the first 5 days after taking the drug, 98% of radioactive has been recovered, 77% from urine, 21% from feces.

At 24 hours after drinking, 43% of radiation was excreted in bile. This finding shows that Eperison hydrochloride participates in the gut -liver cycle. That was seen in mice, mice and hunting dogs. Eperison hydrochloride is metabolized through hydration of carboxylate, an inactive metabolite.

Before taking EPEGIS AGIMEXPHARM improves symptoms of muscle tone (3 blisters x 10 tablets)

How to use

Oral drugs.

Dosage

Usually for adults: take 1 capsule/time x 3 times/day after every meal.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Epegis often has unwanted effects (ADR) such as:

Adultery effects rarely occur: liver, kidney dysfunction, erythrocytes or abnormal hemoglobin values. The above functions should be monitored or perform hematological tests. Stop drugs when there are abnormal signs.

Other adverse effects: rash, mental symptoms such as insomnia, headache, drowsiness, spastic or numbness, tremor. Stomach symptoms such as nausea, vomiting, appetite, dry mouth, constipation, diarrhea, abdominal pain or other digestive disorders, symptoms of urinary disorders.

Stop using the drug and notify the doctor the unwanted effects.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

EPEGIS medicine is contraindicated in the following cases:

Hypersensitivity to the ingredients of the drug.

Be cautious when used

When using the drug may occur symptoms such as insomnia, headache or drowsiness, spastic or numbness, limb tremor. Stop taking the drug or a decrease in the dose when the first sign of those symptoms. Patients who are taking drugs should not drive or control machines.

Be careful when taking medication for patients with liver dysfunction.

Use drugs for women during pregnancy and lactation

Pregnancy

The safety of Eperison hydrochloride during pregnancy is unknown. This drug should only be used for pregnant or pregnant women, if the expected treatment results are more valuable than any possible risk.

Breastfeeding period

Eperison hydrochloride is not recommended for use in breastfeeding women. If necessary, patients should stop breastfeeding.

The effect of the drug on the ability to drive and operate machinery

Patients who are taking drugs should not drive or control machines due to drugs that can cause headaches, drowsiness, tremor.

Drug interaction

A report that refers to eye regulatory disorders that occur after simultaneous use of methocarbamol with Tolperison hydrochloride (a compound structure similar to Eperison).

Notify the doctor that the drugs used during use of EPEGIS.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

Other drugs

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