Eperisone 50 medicine improves symptoms of muscle tone (5 blisters x 10 tablets)

Dosage form Box of 50 capsules
Specifications Eperisone

Ingredient

Composition information	Content
Eperisone	50mg

Uses

indications

Eperisone is indicated in the following cases:

Improve the symptoms of muscle tone related to the following diseases: Cervical vertebrae, ariarthritis) shoulder and waist. head injury), side atrophy (Lou Gehrig), cerebral palsy, spinal degeneration - cerebellum (spinocerebel - lar), spinal vascular disease and other encephalomyelopathies. central and on blood vessel smooth muscles. Eperison has a stable treatment effect in improving various symptoms related to muscle tone, thanks to cutting the pathological spiral of muscle spasms.

Eperison has the main impact on the spinal cord, reducing the marrow reflexes and creating muscle relaxation by reducing the sensitivity of the muscle through the gamma centrifugal system. In addition, the vasodilation impact of the drug increases circulation. Therefore, Eperison is with a diverse method, cutting off the pathological spiral, in which the muscle contraction on the disorder of blood flow, then causes pain and leads to an increase in muscle tone.

Eperison has been shown to be a clinical effect in improving the symptoms of muscle tone, such as shoulder spasticity, neck vertebra, muscle contraction, dizziness, back pain of spasms of limb, can be accompanied by cerebrospinal disease, cervical vertebra syndrome, shoulder and lumbar arthritis.

Clinical Pharmacology

muscle relaxation

Inhibition of experimental muscle spasms: Eperison hydrochloride shows the inhibitory effect depending on the dosage on the brain loss due to the part of the brain (gamma spasm) and the brain loss due to ischemic anemia (alpha spasm) in cats and mice.

Reducing the marrow reflex: Eperison hydrochloride reduces single and synap potential, created by stimulating the centrifugal nerve root in the cat.

This effect depends on the dose of reducing the sensitivity of Eperison Hydrochloride inhibiting the activity of the center -oriented nerve (LA fiber) from the occasion of the person after taking the drug for 20 minutes. Eperison hydrochloride inhibits the voluntary electrical release of gamma mobilization neurons, but does not directly impact on the muscles of animals. So Eperison hydrochloride reduces the sensitivity of the muscle through the gamma motor neurons.

Increase blood flow

Vascular vasodilation effects: Eperison hydrochloride vasodilic effects increase the effects of canceling muscle and antagonistic on vascular smooth muscles in vasodilation.

Increases blood flow: Eperison hydrochloride increases blood volume in the skin, muscle, external carotid artery, internal artery and vertebra artery.

Analgesic effects and pain inhibitors

In mice, Eperison Hydrochorid has the effect of inhibiting pain reflexes - when clamping into the tail of the mouse - but reflexes return when removing clamps at the tail; This shows that Eperison Hydrochorid possesses an analgesic effect at the spine level.

Create easy movement in arbitrary movement

Eperison hydrochloride is used to treat spastic paralysis in brain flood patients (flooded with cerebral blood), improving cybex rotary curves and muscle charts. Eperison hydrochloride makes the active activity easy, such as stretching and folding limbs, without reducing muscle strength.

Dynamic pharmacokinetics

Eperison hydrochloride is used by oral at 8 mature, male and healthy volunteers with a single dose of 150 mg/day, for 14 consecutive days and determining plasma concentrations on day 1, 8 and 14.

Time to achieve peak concentration in plasma (TMAX) ranges from 1.6 to 1.9 hours; Plasma peak concentration (CMAX) reaches 7.5 to 7.9 ng/ml; The average selling time (T1/2) is 1.6 to 1.8 hours and AUC (the area below the drug concentration curve over time) is 19.7 to 21.1 ng*hours/ml. The concentration parameters of Eperison hydrochloride in plasma are determined on the 8th and 14th day are not significantly different from the first days.

absorption - distribution - metabolism and elimination

When 14C - Eperison hydrochloride (Eperison hydrochloride is marked with radioactive 14C) used by oral for mice at a dose of 50 mg/kg, most of the drugs are absorbed through the gastrointestinal tract and the concentration of Eperison hydrochloride in the form of constant plasma. This suggests that the first pass pass (first pass) is relatively high.

After 30 minutes, the radioactive concentration in the brain, spinal cord, thigh nerves and muscles at the same range as blood levels. Within the first 5 days after taking the drug, 98% of radioactive has been recovered, 77% from urine, 21% from feces. At 24 hours after drinking, 43% of radioactivity was excreted in bile. This finding shows that Eperison hydrochloride participates in the gut cycle. That was seen in mice, mice and rabbits. Eperison hydrochloride is metabolized through hydration of carboxylate, an inactive metabolite.

Before taking Eperisone 50 medicine improves symptoms of muscle tone (5 blisters x 10 tablets)

How to use

This drug is only used as prescribed by a doctor. Often oral. Drink after meals.

Dosage

Adults

Normal dose: Take 3 capsules/day; divided into 3 drinks after each meal. Need to adjust the dose according to the patient age and the severity of symptoms.

Elderly

Because the elderly often decreases physiological functions, it is necessary to be cautious when taking the drug and it is necessary to take appropriate measures such as reducing the dose under careful supervision.

Children

Safety in children has not been established (due to insufficient clinical experience).

What to do when overdose?

No report on overdose.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

The adverse reaction was reported at 416/12,315 patients (3.38%) at the end of the re -review period.

Clinical significant adverse reactions (unknown rates).

Shock and anaphylactic reaction: Due to shock and anaphylactic reactions may occur, patients should be carefully monitored. In the event of symptoms such as redness, itching, urticaria, face edema or other parts and shortness of breath ... should stop treatment and apply appropriate treatment measures.

Stevens - Johnson syndrome and toxic epidermal necrosis (Lyell syndrome): Serious skin reactions such as Stevens - Johnson syndrome or poisoning epidermal necrosis (lyell syndrome) may occur.

Patients need to be carefully cared for and supervised, discontinued and implemented appropriate handling measures in the event of symptoms such as fever, erythema, blistering, AV, congestion or stomatitis ....

Common, 5%> ADR> 20.1%

Hypersensitivity: rash.

Mental: Sleep, insomnia, headache and numbness in the limbs. stomach - intestines: Nausea, vomiting, anorexia, stomach discomfort, abdominal pain, diarrhea, constipation and thirst. Body: Weakness, headache due to light and body fatigue. Other: flushing.

Rare, ADR

liver - bile: increased liver enzymes.

kidney: proteinuria and hyperur with blood urea. Hematology: Anemia.

Hypersensitivity: itching.

Mental: Spasticity and tremor.

Stomach - intestines: stomatitis and wide abdominal feeling.

Urinary urology: Slow urine, incontinence and urination feeling.

Body: Reduce muscle tone and dizziness.

Other: sweating and edema.

Unknown ADR ratio

Hypersensitivity: Diverse red fluid.

ADR processing direction

Because these symptoms can occur, patients need to be carefully monitored. In the event of the above abnormalities, the drug should be discontinued and implemented appropriate measures. In case of the above symptoms, the drug should be discontinued.

Warnings

contraindicated

Eperisone is contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug.

Be cautious when taking drugs

When used for pregnant women or suspected pregnancy, should consider effectiveness and consequences.

Do not use Eperisone while breastfeeding. If you have to use Eperison, you should stop breastfeeding during treatment. Eperison reports have been excreted in breast milk in an animal study (rat).

Patients with a history of hypersensitivity of the drug.

Patients with liver dysfunction (Eperison may be worse).

Special prudence:

When using Eperison HCl may occur symptoms such as muscle spasms (Lou Gehrig), light, drowsiness or other symptoms. Patients should be warned to avoid participating in activities that are likely to be dangerous, requiring alertness such as operating machinery or driving.

The ability to drive and operate machinery

Patients should be warned to avoid participating in activities that are likely to be dangerous, requiring alertness such as operating machinery or driving.

During pregnancy and lactation

pregnancy

Not for pregnant women or suspicion of pregnancy, should consider effectiveness and consequences.

Breastfeeding period

Do not use Eperison while breastfeeding. If you have to use Eperison, you should stop breastfeeding during treatment. Eperison reports have been excreted in breast milk in an animal study (rat).

Drug interaction

There was a report of visual disorders after use simultaneously methocarbamol with Tolperisone Hydrochorid, a compound with structure similar to Eperison HCl.

Storage

You should store at room temperature, avoid moisture and avoid light. No storage in the bathroom or in the freezer. You should remember that each drug may have different storage methods. Therefore, you should read carefully storage instructions on the packaging or ask the pharmacist. Keep pills out of reach of children and pets.

Expiry date: 36 months from the date of manufacture.

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