Epigaba 300 pymepharco treatment of epilepsy (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Gabapentin

Ingredient

Composition information	Content
Gabapentin	300mg

Uses

Indications

gabapentin are appointed to the treatment of local epilepsy or secondary alternate episodes in adults and children over 12 years old.

gabapentin is determined to support support in local seizures whether or not accompanied by secondary all -generating attacks in adults and children 3 years of age and older.

Gabapentin is also used to treat pain caused by peripheral nerves in adults.

Pharmacokic

gabapentin is an anti -epileptic drug. The chemical structure of Gabapentin is similar to neurotransmitter inhibitors, Gama-Aminobutyric Acid (GABA), but Gabapentin does not directly affect GABA recipients, does not change the structure, release, metabolism and recovery of GABA.

pharmacokinetics

gabapentin absorbed through the gastrointestinal tract under saturated mechanism (when the dose increases, bioavailability decreases).

The drug reaches the peak concentration in plasma after taking 2 hours and reaches a stable concentration after 1-2 days. Food less affecting the speed and level of absorption.

In elderly patients and patients with impaired renal function, plasma gabapentin clearance is reduced. Gabapentin can be eliminated from plasma by hemolysis, so the dose adjustments for these patients are needed.

gabapentin is distributed throughout the body, entering breast milk, linking with very low plasma proteins (

gabapentin is almost no metabolism in the body and excreted mainly through the kidneys in a constant form.

Half of Gabapentin is about 5 to 7 hours in people with normal kidney function.

Before taking Epigaba 300 pymepharco treatment of epilepsy (10 blisters x 10 tablets)

How to use

gabapentin orally or not with food.

Dosage

Dosage anti -epileptic treatment

Adults, children> 12 years old:

First day: 300 mg/time x 1 time.

Monday: 300 mg/time x 2 times. The maximum dose must not exceed 3600 mg/day divided into 3 times equal.

Dosage of up to 4800 mg/day has been well tolerated in open, long -term clinical studies. The gap between the drug use no more than 12 hours to avoid the outbreak of convulsions.

Children 6-12 years old:

The first day: 10 mg/kg/day, divided 3 times. Total dose/day is divided 3 times.

Dosage to treat pain caused by peripheral nerves in adults, pain after shingles

Adults:

Take no more than 1800 mg/day, divided 3 times. Or use as follows:

First day: 300 mg/time x 1 time.

Monday: 300 mg/time x 2 times. Total dose/day is divided into 3 times/day.

Persons of renal function:

In patients aged 12 years and older with impaired renal function and / or dialysis, the dose must be adjusted depending on the degree of renal failure:

Patients with ClCr ≥ 60 ml/minute: The dose can be up to 400 mg x 3 times/day (equivalent to the total dose may be up to 1200 mg/day). mg x 1 time/day.

In addition, the starting dose of 300–400 mg can be used for these patients.

Elderly:

Elderly patients are more likely to suffer from renal failure, reduce the dose depending on the degree of renal failure and as instructed by a physician.

What do

do when overdose? Most cases of overdose recover after using supportive treatment. There may be drugs from the body by hemolysis.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Gabapentin tolerates well. Unwanted effects (ADR) are usually mild or medium and tend to gradually decrease within 2 weeks when continuing treatment. The most common ADRs for nerves and
are often the cause of drug stops.

Common, ADR> 1/100

Neurological: loss of coordination, vibration of eyeball, fatigue, dizziness, edema, drowsiness, memory loss.

Children from 3 to 12 years old: Mental problems such as anxiety, changing behavior (fussing, feeling refreshing or depression, too excited, anti -opposition attitude ...).

Digestive: indigestion, dry mouth, constipation, abdominal pain, diarrhea.

Cardiovascular: peripheral eagle.

Respiratory: rhinitis, sore throat - pharyngitis, cough, pneumonia.

Eyes: Look at one two, reduce vision.

musculoskeletal: muscle pain, joint pain.

Skin: rashes, skin rash.

Blood: leukopenia.

Other: impotence, virus infection.

Uncommon, 1/1000

Neurology: Memory loss, loss of language, depression, irritability or changes in mind or temperament, mild paralysis, reduction or loss of sensory, headache.

Gastrointestinal: Gastrointestinal disorders, bleeding, stomatitis, loss or taste disorders.

Cardiovascular: Hypotension, angina, peripheral disorders, suspense.

Other: weight gain, liver.

Rare, ADR

Neurological: Neurological paralysis, personality disorders, increased sensitivity, reduced exercise function, mental disorders.

Gastrointestinal: gastric ulcer - duodenum, esophagitis, colitis, rectal inflammation.

Respiratory: cough, hoarse, respiratory mucosa, decreased pulmonary ventilation, pulmonary edema.

Eyes: itchy eyes, watery eyes, retinopathy, iritis.

Bone muscle: cartilage, osteoporosis, back pain.

Blood: leukopenia (usually asymptomatic), prolonged bleeding time.

Fever or cold.

Stevens-Johnson syndrome.

Notice the unwanted physician when using the drug.

Instructions on how to handle ADR:

Loss of movement combination is usually related to the dose. If the dose is reduced without helping, it is necessary to stop the drug.

If there is a suspected Stevens-Johnson syndrome, the drug must be stopped.

Do not stop the drug suddenly because it can increase the frequency of seizures. Before stopping the drug or switching to other anti -epileptic drugs, it is necessary to reduce the dose slowly within 7 days.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Epigaba 300 is contraindicated in the case of patients sensitive to the ingredients of the drug.

Be cautious when using

although there is no evidence of epilepsy outbreaks with Gabapentin, the sudden stop of anti -seizures in epilepsy patients can cause continuous seizures (epilepsy) in patients. Once the doctor's judgment is that it is necessary to reduce the dose, stop the drug, or replace it with other anti -convulsions, these jobs should be done slowly for a minimum period of 1 week.

Patients treated simultaneously with morphine may increase gabapentin levels. Caution should be monitored for the patient's central nervous manifestations (such as sleeping) and reducing the dose of gabapentin or morphine appropriately.

Need to monitor signs related to the patient's suicidal thoughts and behaviors such as new or depressed worse and/or any abnormal changes in mood or behavior. Report immediately to the doctor if there is any relevant symptoms.

Stop using the drug if the patient has acute pancreatitis.

Be cautious when long -term treatment in teenagers.

Be cautious about using drugs for people with a history of mental disorders, people with impaired renal function and hemolysis.

The drug can cause unwanted effects such as dizziness, drowsiness. Therefore, it is best not to use gabapentin while driving or operating machinery,

The drug can cause false positive when testing proteinuria.

The ability to drive and operate machinery

The drug hardly affects the ability to drive and operate machinery. However, there are also a few reports on the risk of dizziness, so the doctor may depend on the specific case that is recommended or not recommended for patients to use drugs when driving and operating machinery.

Pregnant and lactating women

gabapentin causes teratogen on rodent. On pregnant people, have not seen the same effect.

However, only medication for pregnant women when they really need and consider higher benefits than the risk for the fetus.

When taken orally, gabapentin gets breast milk. The effect of the drug on infants is still unknown, so only gabapentin for women during breastfeeding when they are really necessary and have carefully considered the benefits higher than the risk risk.

Only use drugs when the benefits are higher than the risk.

Drug interaction

When used simultaneously, gabapentin does not change the dynamics of commonly used anti -epileptic drugs such as carbamazepin, phenytoin, valproic acid, phenobarbital, diazepam. Study in a state of plasma concentration in both drugs.

Antacomic antacids containing aluminum salt and magnesium salt reduces the bioavailability of gabapentin by about 20% due to the effects on the absorption of the drug. Gabapentin must be used after at least 2 hours of antacids.

The excretion of the kidney gabapentin is not affected by probenecid.

Biochemical tests: The false positive results have been reported in tests using Ames N-Multistix SG dip sticks (when combining gabapentin with other anticonvulsants). Therefore, to determine the protein in the urine, it is recommended to precipitate sulfosalicylic acid.

Storage

In a dry, cool place (below 30 ° C). Avoid light.

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