Erythromycin 250mg Mekophar Treatment of infection (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Erythromycin

Ingredient

Composition information	Content
Erythromycin	250mg

Uses

indications

erythromycin is indicated in the following cases:

Treatment of bacterial infections caused by bacteria in the respiratory tract (bronchial, lungs, ears - nose - throat), skin and soft tissue, gastrointestinal tract, urinary tract - genitals, especially prostate, bone, erythasma and dental mushrooms. Learning

erythromycin is a macrolid antibiotic, which has a broad spectrum, mainly bacteria for gram -positive bacteria, gram -negative and other bacteria including Mycoplasma, Spirochetes, Chlamydia and Rickettsia.

erythromycin and other macrolids are associated with the 50S unit subunit of ribosom sensitive bacteria and protein synthesis inhibitors. The main effect of erythromycin is bactericidal but can kill bacteria at high concentrations for very sensitive strains. The effect of the drug increases in mild alkaline pH (about 8.5), especially with Gram -negative bacteria.

erythromycin has a broad spectrum with pathogenic bacteria including Gram -positive bacteria, Streptococcus such as Streptococcus Pneumoniae, Streptococcus Pyogenes. Many staphylococcus aureus strains are still sensitive, although the resistance increases rapidly.

The data in the ASTS report shows that in recent years, Staphylococcus, Pneumococcus, Streptococcus blood solubility group A resistant to Erythromycin increased much, the resistance rate increased by 40% (Streptococcus pneumoniae), 55% (Enteroccus FAECALIS), 51% (Streptoccus vidrids) and Streptoccus Vidans) and 51% (Streptoccus Vidans) and 51 59% (Staphylococcus aureus). Erythromycin resistance increases each year in Vietnam due to the abuse of macrolids. Macrolids in general and Erythromycin in particular must be limited to use, only used when needed, so that the chance of reducing drug resistance.

Many other Gram -positive bacteria are also sensitive to erythromycin including: Bacillus anthracis, corynebacterium diphteria, erysipelothris rhusioparthiae, listeria monocyogenes.

Medium -acting drugs with anaerobic bacteria such as Clostridium spp., Nocardia types change sensitivity but Erythromycin still works with propionibacterium acnes. Erythromycin works with Gram -negative bacteria such as Neisseria Meningitidis, N. Gonorrheae and Moraxella (Branhamella) Catnrhalis.

Other Gram -negative bacteria have a change in sensitivity but the drug still works effectively: Bordetella spp., some Brucella, Flavobacterium, Legionella spp. And Pasteurella, Haemophilus Ducreyi is still sensitive, but H. Influenzae is less sensitive. Entobacteriaceae are generally not sensitive, but some sensitive strains with alkaline drugs.

In Gram -negative anaerobic bacteria, Helicobacter PyloRidis and many Campylobacter Jejuni strains are sensitive (about 10% of the following strains are resistant). More than half of the bacterioides Fragilis strains and many Fusobacterium strains are resistant to erythromycin.

Other bacteria are sensitive to drugs including Actinomyces, Chlamydia, Rickettsia spp, Spirochete such as Treponema Pallidum and Borrelia Burgdorferi, some Mycoplasma (especially M. Pneumoniae) and some Mycobacteria chances as M. Scrofalaceum and M. Kansas, but M. Kansas, but M. Kansas, but M. Kansasi Mycoplasma in cells is usually resistant, including M. Fortuitum.

Mushrooms, yeast and viruses are all resistant to erythromycin. The minimum inhibitory concentration of erythromycin can be lower than 0.001 micrograms/ml for Mycoplasma Pneumoniae and the minimum inhibitory concentration from 0.01 - 0.25 micrograms/ml exchange with Listeria, Neisseria Gonorrheae and Corynebacterium Diphteria, Moraxella CatVrhalis and Bordetella and Bordetella pertussis.

Bacteria with a minimum inhibitory concentration of 0.5 micrograms/ml are considered to be sensitive to antibiotics and bacteria with a minimum inhibitor from 0.5 - 2 micrograms/ml with average sensitivity.

Pharmacokinetics

absorption

The drug is better absorbed when used during meals.

Distribution

The drug is widely distributed throughout the fluid and tissue, including the middle -eared fluid, prostate and semen. The highest concentration is seen in the liver, bile and spleen. The drug has low concentrations in cerebrospinal fluid, but when the meninges are inflamed, the concentration of the medication in the cerebrospinal fluid increases.

from 70 to 90% of the drug is attached to the protein. More than 90% of the metabolic drug in the liver, partly in the form of inactiveness; can accumulate in patients with severe liver failure.

Peak concentration in plasma reaches 1 to 4 hours after taken, depending on the type of drug. Achieving concentration of 0.3 - 0.5 micrograms/ml with erythromycin base 250 mg and 0.3 - 1.9 micrograms/ml at a dose of 500 mg. Erythromycin ethylsucinat 500 mg reaches a peak concentration of about 0.5 micrograms/ml.

Elimination

erythromycin eliminates mainly. From 2 to 5% of oral doses excreted urine in the form of unchanged.

Before taking Erythromycin 250mg Mekophar Treatment of infection (10 blisters x 10 tablets)

How to use

The best absorbed drug when taken with meals.

Dosage

Average dose

Adults: Take 1 - 2 g (4 - 8 packs)/day divided into 2-4 times. When severe infections can be taken up to 4 g (16 packs), divided into several times.

Children: Take 30 - 50 mg/kg body weight/day, divided into 3-4 times. In case of severe infections, the dose may double.

Children from 2 - 8 years old: Take 1 g (4 packs), divided into several times.

Children under 2 years: Take 500 mg (2 packs), divided into several times.

Use 5 - 10 days.

(this drug is only used as prescribed by a physician).

What do

do when overdose?

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using erythromycin 250 mg you may experience some unwanted effects (ADR).

Unwanted effects of the drug: The drug is usually good tolerated and rarely has unwanted reactions. About 5-15% of patients use erythromycin has unwanted effects. The most common are digestive issues, especially with high doses and local irritation.

Common

Digestive: abdominal pain, vomiting, diarrhea.

DA: BOARD.

Less

Skin: urticaria.

Rare

Body: Anaphylaxis.

Circulation: arrhythmia. liver: Transaminase increases, serum bilirubin increases, cholestasis in the liver. ears: deaf, recovery.

ADR processing direction

Notify the doctor with unwanted effects when using the drug.

Warnings

Contraindicated

Patients with hypersensitivity to erythromycin, patients who used to use erythromycin that had liver disorders, patients with a history of deafness.

The use is considered unsafe for patients with acute porphyrin metabolism disorders, because of acute batches.

Do not coordinate with terfenadin, especially in the case of patients with heart disease, arrhythmia, bradycardia, about 2 - T prolonged, ischemic heart, or patients with electrolyte disorders.

Be cautious when taking drugs

Need to use very carefully in the form of erythromycin for patients who are liver or liver failure. It is also necessary to be very cautious when used with patients with arrhythmia and other heart disease.

The ability to drive and operate machinery

The drug does not affect the operation of the person when driving or operating machinery.

During pregnancy and lactation

pregnancy

Be cautious when used for pregnant women. When necessary to use should consult a doctor to consider benefits and risks.

Breastfeeding period

The period of breastfeeding should be used cautiously. If necessary, should consult a doctor to consider the benefits of the mother and the risk for children.

Interactive drug

Be careful when taking Erythromycin with the following drugs:

erythromycin reduces plasma clearance and prolongs the effect time of alfentanil. Valproic, increasing the concentration of these drugs in plasma and increases toxicity. In case of fast bactericidal effect. It is best to avoid coordination. If necessary, dose adjustment. Midazolam or triazolam's clearance and increases the effects of these drugs.

erythromycin increases plasma ciclosporin levels and increases the risk of toxicity to the kidneys.

Storage

You should store at room temperature, avoid moisture and avoid light. No storage in the bathroom or in the freezer. You should remember that each drug may have different storage methods. Therefore, you should read carefully storage instructions on the packaging or ask the pharmacist.

Keep pills out of reach of children and pets.

Expiry date: 24 months from the date of manufacture.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.