Esapbe 40 Sterling Healthcare treat gastroesophageal reflux (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Esomeprazol

Ingredient

Composition information	Content
Esomeprazol	40mg

Uses

indications

Esapbe 40 mg is indicated in the following cases:

Treatment of gastroesophageal reflux disease (GERD):

Treatment of reflux inflammation.

duodenum ulcer caused by Helicobacter pylori.

Stomach ulcer due to nsaid.

Pharmacokology

Esomeprazole is the S-isomer of Omeprazole and reduces the excretion of stomach acid with a specialized mechanism of action. The drug is a specific inhibitor of acid pump in the wall of the wall. Both types of isomers R-and S-S- of Omeprazole have similar pharmacological effects. Esomeprazole is a weak alkaline, concentrated and transformed into an active form in a high acidic environment in the sub-traces of the cell's secretion, where H+K+-Aatpase inhibitors (acid pumps) and inhibit both basic fluid and stimulating fluid.

Dynamic pharmacokinetics

Esomeprazole absorb fast, plasma peak concentration achieved after 1-2 hours. Absolute bioavailability is 50% after taking a single dose of 20 mg and increasing by 68% after taking the dose once a day. Esomeprazole is completely metabolized through the Cytochrome P450 (CYP) system. Esomeprazole completely eliminated from plasma between doses without accumulating when used once a day.

The average peak concentration of the drug in the corresponding oral form in plasma is about 4.6 mcmol/l. The main metabolites of Esomeprazole do not affect the secretion of stomach acid. About 80% of Esomeprazole oral dose is excreted in the urine in the form of metabolites, the rest through the feces. Less than 1% of the drug is found in urine in constant form.

Before taking Esapbe 40 Sterling Healthcare treat gastroesophageal reflux (3 blisters x 10 tablets)

How to use

all members should be taken with water, should not chew or crush capsules.

Dosage

adults

Gastroesophageal reflux disease (GERD)

Treatment of esophagitis due to reflux: 40 mg/day for 4 weeks. It is recommended to treat 4 more weeks in patients with unprecedented esophagitis or patients with persistent symptoms.

Long -term prevention treatment in cases of esophagitis has recovered: 20 mg/day.

Treatment of symptoms of gastroesophageal reflux disease: 20 mg/day in patients without esophagitis.

Combined with an appropriate antibacterial regimen to eradicate Helicobacter pylori

Healing duodenal ulcer and prevent recurrence of peptic ulcer contaminated with Helicobacter pylori: (Esomeprazole 40 mg + amoxicillin 1 g and Clarithromycin 500 mg) x 2 times/day x 7 days.

Patients need to be treated with NSAID continuously:

Heals stomach ulcers due to NSAID use: normal dose 20 mg once a day. Treatment period is 4-8 weeks.

Prevention of stomach ulcers and duodenal ulcers due to NSAID in patients at risk:

20 mg/day.

Treatment of Zollinger Ellison syndrome

The recommended starting dose is 40 mg x 2 times/day. The dose then should be adjusted by individuals and continue treatment according to clinical signs. Based on clinical data, most patients can be controlled at the dose from 80-160 mg Esomeprazole daily. With a dose of over 80 mg/day, the dose should be divided into 2 times.

Children under 12 years old

Do not use for children because there is no data.

Other objects

Persons of renal function: No dose adjustment in patients with renal function. Due to the limited treatment for patients with patients with kidney failure, caution should be cautious when taking the drug on this object.

People with liver function: No dose adjustment in patients with mild to medium liver function failure. For patients with severe liver failure, maximum overdose should not be used for 20mg Esomeprazole every day

Elderly: No need to adjust the dose in the elderly.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? The described symptoms related to the use of 280 mg oral dose are symptoms on the gastrointestinal tract and weakness. Dsomeprazole single doses of oral 80 mg and a 100 mg intravenous form are still safe to use. There is no specific detox. Esomeprazole is strongly connected to plasma proteins and therefore not easily separated. In case of overdose, symptomatic treatment and use of general support measures.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Esapbe 40mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neurological: headache .

digestive: abdominal pain, diarrhea , flatulence, nausea/vomiting, constipation.

Uncommon, 1/1000

Skin: Dermatitis, itching, urticaria.

nerve: dizziness.

eyes: blurred vision.

digestive: dry mouth .

Rare, ADR

Body/DA: Hypersensitivity reactions such as angioedema, anaphylactic reaction, Stevens Johnson syndrome, diverse roses.

muscle-muscle: muscle pain.

liver: liver enzyme.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Esapbe 40mg drug contraindicated in cases of hypersensitivity to Esomeprazole, Benzimidazole or other ingredients in the formula.

Be cautious when using

When there is a significant vigilant symptom such as significant weight loss, recurrent vomiting, difficulty swallowing, vomiting of blood or elements of black blood and when there is or suspected stomach ulcers, it should eliminate malignant ability because Esomeprazole treatment can cover symptoms and delay diagnosis.

The ability to drive and operate machinery

Esomeprazole has a small impact on the ability to drive or use machinery. Harmful reactions such as dizziness (not common) and blurred vision (rare) have been reported. If the patient is affected, you should not drive or use machines.

Pregnancy

should be cautious when prescribing Esomeprazole for pregnant women.

The period of breastfeeding

It is unknown that Esomeprazole secretes breast milk or wise. Research on breastfeeding women has not been conducted. Therefore, you should not use Esomeprazole during breastfeeding.

Drug interaction

The reduction of stomach acid when treated with Esomeprazole may increase or reduce the absorption of other drugs if the absorption mechanism of these drugs is affected by thick acidity. Like other gastric acid secretions or antacids, the absorption of ketoconazole and iTraconazole may decrease during treatment with Esomeprazole.

Esomeprazole inhibits CYP2C19, so when Esomeprazole is used with metabolic drugs through CYP2C19 such as diazepam, imipramine , clomipramine , phenytoin ..., the concentration of these drugs in soy sauce can increase and need to decrease the dose.

Storage

Store in a cool dry place. Avoid light.

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