Esomeprazole 20mg Stada treat gastroesophageal reflux, esophagus (4 blisters x 7 tablets)

Dosage form Box of 4 blisters x 7 tablets
Specifications Esomeprazole

Ingredient

Composition information	Content
Esomeprazole	20mg

Uses

Indications

Esomeprazol 20 Stada is indicated in the following cases:

Gastroesophageal reflux disease (GERD): Treatment of esophageal scratches due to reflux; Long -term treatment for patients with healed esophagitis to prevent recurrence; Treatment of symptoms of gastroesophageal reflux disease (GERD).

Combined with an appropriate antibacterial regimen to eradicate Helicobacter pylori, heal duodenal ulcer due to Helicobacter pylori infection and prevent recurrence of peptic ulcer in patients with Helicobacter pylori infection.

Patients who need to treat non-steroid anti-inflammatory drugs (NSAID) continuous: Healing stomach ulcers due to NSAID drugs; Prevention of stomach ulcers and duodenal ulcer due to NSAID drugs in risky patients.

Treatment of Zollinger - Ellison syndrome.

Pharmacy

Esomeprazol is a proton pump inhibitor that reduces gastric acid secretion by inhibiting enzyme H+/K+ - Atpase in the cell wall of the stomach.

Esomeprazol is the isomorphic S of omeprazol, protonized and transformed in the acidic compartment of the cell into an active inhibitor, an air -contrast sulphenamide form. Due to the special effects on proton pumps, Esomeprazol blocks the final step in the production of acid, thereby reducing stomach acid. This effect depends on the daily dose of 20 - 40mg and leads to inhibition of stomach acid secretion.

Dynamic pharmacy

Esomeprazol is quickly absorbed after oral, the peak concentration in plasma is achieved after 1-2 hours. Esomeprazol's bioavailability increases with the dose and when used to repeat, reaching about 68% when taking the dose of 20mg and 89% when taking the dose of 40 mg. The food slows down and reduces the absorption of ecomeprazol, but does not significantly change the effect of ecomeprazol on the acidity in the stomach. Esomeprazol binds to plasma proteins about 97%. The drug is metabolized mainly in the liver thanks to isoenzyme CYP2C19 Cytochrom P450 enzyme system into hydroxy and desmethyl metabolites.The rest is converted through isenzyme CYP3A4 to Esomeprazol Sulfon. When used repeated, initially metabolized through the liver and the clearance of the drug reduced, possibly due to the inhibited ISOENZYM CYP2C19. However, there is no accumulation when used once a day. Selling time for plasma is about 1.3 hours. Most 80% of oral dose are eliminated in the form of metabolites in urine, the rest is eliminated through feces.

Before taking Esomeprazole 20mg Stada treat gastroesophageal reflux, esophagus (4 blisters x 7 tablets)

How to use

oral drugs. Esomeprazol 20 Stada should be swallowed with some water. Do not chew or crush capsules.

Dosage

adults and adolescents aged 12 and older

Gastroesophageal reflux disease (GERD):

Treatment of esophageal scratches due to reflux:

40mg x 1 time/day for 4 weeks. Should treat 4 more weeks for patients with untreated esophagitis patients or persistent symptoms.

Long -term treatment for patients with healed esophagitis to prevent recurrence:

20mg x 1 time/day.

Treatment of symptoms of gastroesophageal reflux disease (gerd):

20mg x 1 time/day in patients without esophagitis. If the symptoms are not controlled after 4 weeks, patients should be diagnosed with further diagnosis. Once the symptoms are over, the symptom control can be maintained at a dose of 20mg x 1 time/day.

In adults, you can use the treatment regime when necessary at a dose of 20mg x 1 time/day. In patients with gastroesophageal reflux disease (GERD), NSAID is at risk of developing peptic ulcer, do not recommend controlling symptoms by treatment when necessary.

20mg Esomeprazol, 1 g amoxicillin and 500mg clarithromycin, all used 2 times/day for 7 days.

Patients need to be treated with anti-inflammatory drugs (NSAID) continuously:

Healing stomach ulcers due to nsaid:

Normal dose 20mg x 1 time/day. Treatment period is 4 - 8 weeks.

Prevention of stomach ulcers and duodenal ulcers due to nsaid drugs in patients at risk:

20mg x 1 time/day.

Treatment of Zollinger syndrome - Ellison:

The recommended starting dose is Esomeprazol 40mg x 2 times/day. Then adjust the dose according to the response of each patient and continue treatment when clinically indicated.

Clinical data shows that most patients are controlled with Esomeprazol dose of 80 - 160mg/day. When the daily dose is greater than 80mg, the dose should be divided into 2 times/day.

Children under 12 years old

Do not use Esomeprazol capsules for children under 12 years old because there is no data.

People with kidney function damage

No dose adjustment in patients with kidney function damage. Due to less experience in using drugs in patients with severe renal impairment, caution should be careful when treating in these patients.

Liver function damage

No dose adjustment in patients with liver damage from mild to medium, in patients with severe liver failure, should not overdose for a maximum of 20mg of Esomeprazol.

Elderly

No dose adjustment in the elderly.

What to do when overdose? The described symptoms related to the use of 280mg dose are symptoms on the gastrointestinal tract and fatigue. Single doses of 80mg Esomeprazol are still safe to use. There is no specific detox. Esomeprazol is strongly connected to plasma proteins so it is not easy to fecal. In case of overdose, symptomatic treatment and use of general support measures.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Esomeprazol 20 Stada, you may experience unwanted effects (ADR).

Common: 1/10

Systemic: headache, dizziness, skin extra skin.

digestive: Nausea, vomiting, abdominal pain, diarrhea, constipation, flatulence, dry mouth.

Few: 1/100

Body: fatigue, insomnia, rash, itching, visual disorders.

Rare: 1/1000

Systemic: Fever, sweat, peripheral edema, sensitivity to light, hypersensitivity reactions (including urticaria, angioedema, bronchospasm, anaphylactic shock).

Central nerve: agitation, depression, confusion with recovery, hallucinations in serious illnesses. Hematology: granulocytic loss, leukopenia, reduction of pepper. liver: Increased liver enzyme, hepatitis, jaundice, liver function. digestion: taste disorders.

Muscle muscle: joint pain, muscle pain.

urinary: interstitial nephritis. skin: bullous rash, Stevens - Johnson syndrome, poisoned epidermal necrosis, dermatitis. infection: Due to reducing the acidity of the stomach, proton pump inhibitors may increase the risk of bacterial infections in the gastrointestinal tract.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Esomeprazol 20 Stada is contraindicated in the following cases:

Patients with hypersensitivity to Esomeprazol, benzimidazol derivatives or any ingredients of the drug.

First 3 months of pregnancy.

Precautions when using

when there is any alert symptom (such as significant weight loss, recurrent vomiting, difficulty swallowing, vomiting of blood or black defecation) and when suspected or stomach ulcers should eliminate malignant diseases because treated with Esomeprazol can reduce symptoms and delay diagnosis.

Using proton pump inhibitors, especially when taking high doses and for a long time (> 1 year), may increase the risk of hip, wrist and backbone fractures, mainly occurs in the elderly or when there are other risk factors. Observations show that proton pump inhibitors increase the risk of fractures from 10 to 40%. Some of these increase may be due to other risk factors. Patients at risk of osteoporosis must be cared for under the current clinical instructions and need adequate vitamin D and calcium.

When prescribing Esomeprazol to eliminate Helicobacter pylori, drug interactions should be considered in the 3 -drug treatment regimen. Clarithromycin is a strong CYP3A4 inhibitor and therefore should consider contraindicated and interact with Clarithromycin when using a 3 -drug regimen for patients who are taking other drugs metabolized through CYP3A4 as Cisaprid.

Symptomic and asymptomatic magnesi has been reported rare in patients treated with proton pump inhibitors for at least 3 months, most cases on patients after 1 year treatment. Serious unwanted effects include muscle spasm, arrhythmia and epilepsy. Most patients need to supplement Magnesi to treat blood magnesium or stop using proton pump inhibitors, need to consider monitoring blood magnesium levels while starting treatment with proton pump inhibitors and periodically in patients who have to treat long -term or use proton pump inhibitors with other drugs such as Digoxin or drugs that cause blood reduces (for example, for example, diuretic.

Reducing stomach acid for any cause, including using proton pump inhibitors, increasing the number of permanent bacteria in the digestive tract. Proton pump inhibitors may slightly increase the risk of gastrointestinal infections caused by Salmonella and Campylobacter.

The ability to drive and operate machinery

Patients with dizziness or hallucinations while using Esomeprazol should not drive or operate machinery.

Pregnancy

There has been no adequate and controlled research on pregnant women. Only use drugs for pregnant women when really necessary.

Breastfeeding period

It is unknown whether esomeprazol is excreted through breast milk or not, no studies in nursing women. Therefore, Esomeprazol should not be used while breastfeeding.

Medicinal interaction

The drug with pH dependent of the stomach

The absorption of ketoconazole, iTraconazole may decrease during treatment with ecomeprazol.

Use omeprazol combination (40mg x 1 time/day) with Atazanavir 300mg/Ritonavir 100mg in healthy volunteers reducing the response of Atazanavir.

Metabolic drug thanks to CYP2C19

Esomeprazol is a CYP2C19 inhibitor. When starting or stopping treatment with Esomeprazol, it is necessary to consider the ability to interact with metabolic drugs through CYP2C19. An interaction is observed between clopidogrel and omeprazol. It is unclear clinical significance of this interaction. To prevent, should not use Esomeprazol and Clopidogrel simultaneously.

When Esomeprazol is used with metabolic drugs by CYP2C19, such as diazepam, citalopram, imipramin, clomipramin, phenytoin .... The concentration of these drugs in plasma can increase and need to decrease the dose. Should monitor phenytoin concentration in plasma when starting or stopping treatment with Esomeprazol.

In a clinical trial, when using 40mg of Esomeprazol for patients who have used Warfarin shows that blood clotting time is still within the allowed limit. However, some cases of high clinical increase Inr have been reported when used in combination with warfarin and esomeprazol.

Storage

In closed packaging, dry place, avoiding light. The temperature does not exceed 30 ° C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.