Estaceptin Abbott daily contraceptive pills (1 blister x 28 tablets)

Dosage form Film bag tablets
Specifications Box of 1 blister x 28 tablets
Ingredient Desogestrel, ethinyletradiol

Ingredient

Thành phần cho 1 viên

Composition information	Content
Desogestrel	0.15mg
Ethinylestradiol	0.02mg

Uses

Indications

Estraceptin drug 0.15 mg is indicated in the following case:

contraceptive.

The combination of estrogen and progestin has the effect of inhibiting the hypothalamus-yen hypothalamus, reducing the secretion of GNRH genital hormones.

Progestagen (Desogestrel) reduces the release of the hormone (LH) necessary for ovulation. Estrogen (Ethinylestradiol) inhibits follicle stimulating hormones (FSH). Both of these substances inhibit ripe ovules and ovulation. The impact of the force of Desogestrel and Ethinylestradiol prevents ovulation, so the main effect is contraception.

In addition, other effects also contribute to contraception, including slowing endometrial proliferation, thus preventing the nest of the eggs fertilized and causing changes in uterine mucus reduces the ability of sperm to meet eggs.

In addition to the above effects of the contraceptive combination of two components, the last tablets have only estrogen (ethinylestradiol) low doses that inhibit the growth of the follicle, reduce the ability to release the ovary that has the effect of contraception and reduce other side effects such as mid -blood bleeding, premenstrual symptoms, headaches when menstruation, menstrual pain.

Dynamic pharmacokinetics

Desogestrel

absorption:

After drinking, Desogestrel is absorbed quickly and almost completely in the digestive tract, then transformed into 3-keto-Desogestrel, which is a biological metabolic. The average peak concentration in plasma (cmax) is about 2 µg/ml, achieved after about 1.5 hours (TMAX). The bioavailability of Desogestrel is 62 - 81%.

Distribution:

3-keto-Desogestrel linked with plasma proteins about 66% (with albumin) and Globulin-Hormon complex of about 31%, the distribution integral is 1.51/kg.

Metabolism:

In addition to 3-keto-Desogestrel is the main biological metabolic substance, created in the liver and on the intestinal wall, the further metabolites of Desogestrel are 3A-Oh-Desogestrel and 3A-OH-51-H-Desogestrel (called phase I). These metabolites have no pharmacological activity and are later transformed into polarized metabolites, mainly in the form of sulfate and glucoronid, partly in the form of combined (phase metabolic II). Plasma clearance is about 2 ml/min/kg.

Era:

The average selling time of 3-keto-Desogestrel is 30 hours. 45% of the drug excreted in urine, more than 30% in feces. The content in a stable state is achieved in the second half of the cycle, when the plasma content of ketogestrel is 2-3 times.

ethinyl estradiol

absorption:

Quick absorption and almost entirely through the digestive tract. The average peak concentration in CMAX plasma is about 80 µg/ml, achieved after about 1-3 hours (TMAX). Due to the first system conjugation and metabolic effect, the absolute bioavailability of Ethinyl Estradiol is nearly 60%.

Distribution:

Ethinyl estradiol binds almost completely with plasma proteins, especially with albumin and sharply increases SHBG content in plasma. The distribution volume is 51/kg.

Metabolism:

Ethinyl estradiol has a strong system conjugation. Not mounted on the intestinal wall, it is subjected to phase and conjugate metabolism in the liver (metabolism of phase II). Ethinyl estradiol as well as phase I metabolites, into the bile in the form of glucuronic and sulfate complex and in the intestinal circulation. Plasma clearance is about 5 ml/min/kg.

Era:

Ethinyl estradiol's exhaust time is about 24 hours. About 40% excreted through urine, 60% in feces in the form of glucoronic and sulfate complex.

The content in a stable state is achieved after 3-4 days, when the plasma content of this drug is about 0 - 40% higher than the single dose.

Before taking Estaceptin Abbott daily contraceptive pills (1 blister x 28 tablets)

How to use and dose

Start taking the tablet with the number 1 on the back of the blister, on the first day of the menstrual cycle.

Take 1 tablet daily in 28 days in the following order: 21 white tablets, 2 green tablets, 5 golden tablets, keep the order and arrow afternoon until the drug is finished. Should record the day of the week starting to take the first tablet, this day will always be the beginning when using the next blister.

After taking the last pill of the blister, start taking the No. 1 pill of the new blister on the next day, even if you haven't seen menstruation or have been discontinued.

It is necessary to remember the number 1 tablet day (day 1), and the 8, 15, 22 days will always happen the same day of the week. This will help check if the drug is done properly.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Must go to the doctor as soon as an overdose. Gastric lavage should be carried out, supportive and maintained therapies. Symptoms overdose in children when taking high doses of estraceptin have not been reported.

What to do when forgetting a dose?

If you forget to take the medicine, you must take it back immediately after remembering, as soon as possible, not to leave 12 hours after the daily medication.

If it has been left for more than 12 hours, the ability to ensure contraception is no longer sure. Continue to take the remaining tablets at a regular time and should use an extra contraceptive method until the end of the cycle. In this case, it is necessary to try pregnant or not before starting the medication for the next cycle.

Side Effects

When using 0.15 mg estraceptin, you may experience unwanted effects (ADR).

Rare, 1/10000

liver - bile: jaundice bile, liver tumor, risk of gallstones.

Disorders of metabolic and nutrition: hyperlipidemia, diabetes, weight gain.

genital: severe breast pain, benign or malignant mammary glands, uterine tumors, increased milk secretion, breast tightness, bleeding between menstrual cycles; Low menstruation; Vaginal candidiasis. Neurology: Nausea, headache, irritability or depression.

Other: Hypertension, need to be diagnosed with pituitary gland, melasma ...

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Estraceptin 0.15 mg contraindicated in the following cases:

Not used in diseases:

Tasiasis thrombosis, hydromomemia; blood vessel disease in the heart, brain, or eyes; renal failure; Malignant tumors in the breast, uterus or pituitary gland depend on hormones; serious or onset liver failure; Genital bleeding has not been diagnosed, Porphyria; ear fibroids; diabetes; increased blood lipids; recurrent cholestatic stasis; History of herpes during pregnancy; pregnant; breastfeeding; Jaundice during pregnancy is unknown.

Relative contraindications:

Metabolic disorders, diseases such as obesity; Increase milk secretion, with high prolactin levels; History of untreated gallstones.

Be cautious when using

need to stop the drug when there are the following symptoms: severe or abnormal headache, visual changes, hypertension.

Note: Periodic health examination before and during treatment; Special monitoring in patients with epilepsy, migraine, asthma, depression, and family history of breast cancer; In the case of gastrointestinal disorders such as vomiting, may reduce the effect of the drug; In case of surgical plans, the drug must be stopped 1 month before surgery and must not continue treatment in the period of unable to travel; Stop treatment in case of a long -term place.

The ability to drive and operate machinery

There is no report.

Pregnancy

Do not take medicine for pregnant women.

The period of breastfeeding

Not used for breastfeeding women because the hormone can affect the baby.

Interactive drug

inform the doctor all the drugs you are taking, including non -prescribing drugs.

Interactions can occur with the following drugs:

Used with troleandomycine increases the risk of jaundice.

It is recommended not to use with enamel induction drugs such as Barbiturat, Phenytoin, Primidone, Carbamazepin, Rifampin, Griseofulvin because of contraception.

Storage

Keep the drug in dry, cool, avoid light, below 30 ° C and be out of reach of children.

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