Ethambutol 400 mekophar medicine for new tuberculosis and recurrent tuberculosis (20 blisters x 10 tablets)

Dosage form Box of 20 blisters x 10 tablets
Specifications Ethambutol

Ingredient

Composition information	Content
Ethambutol	400mg

Uses

indications

Ethambutol 400mg drug is indicated in the following cases:

Treatment of both new tuberculosis and recurrence and must always be used in combination with other anti -tuberculosis drugs such as Isoniazid, Rifampicin, Streptomycin and Pyrazinamide to prevent drug resistance.

Nearly all mycobacterium tuberculosis, M. Kansasii and some M. Avium strains are sensitive to ethambutol. The drug also inhibits the growth of most strains of Isoniazid and Streptomycin. If ETHAMBUTOL is used for poisoning, anti -drug bacteria grow very fast, so to treat tuberculosis, it must be used in combination with other anti -tuberculosis drugs.

The mechanism of the effect of ethambutol is to inhibit mycolic acid penetrating into the wall of tuberculosis bacteria cells. In addition, the drug also restricts the cause of bacteria by preventing the total RNA.

Dynamic pharmacokinetics

Ethambutol is quickly absorbed (75 - 80%) through the gastrointestinal tract, distributed into all tissues, including lungs, kidneys and red blood cells. The drug in cerebrospinal fluid when the meninges are inflamed, the drug also goes through the placenta and the breast milk. The sale time of the drug after taken is 3-4 hours and can last up to 8 hours if the kidney failure. Ethambutol eliminates urine up to 80% within 24 hours. Eliminate ETHAMBUTOL by peritoneal fertilizer and at a lower level of artificial kidney fertilizer.

Before taking Ethambutol 400 mekophar medicine for new tuberculosis and recurrent tuberculosis (20 blisters x 10 tablets)

How to use

Ethambutol 400mg oral drug. The drug can be taken with food if the gastrointestinal tract is irritated. It is possible to grind the pills into flour, mixed with apple juice, not mixed with other juices or other syrups because it does not lose the bitter or unstable taste.

Used to treat tuberculosis or infections of mycobacterium avium complex, combined with other anti -tuberculosis drugs according to the treatment regimen to avoid developing drug resistance.

To achieve the concentration of therapeutic therapeutic concentration should take a single dose of the day.

Dosage

Adults:

New tuberculosis patients: 15mg/kg body weight/day, maximum 1.6g/day.

Patients with recurrent tuberculosis: 25mg/kg body weight/day for the first 60 days, then drink 15mg/kg body weight/day, maximum 1.6g/day.

Children:

Patients with new tuberculosis and recurrent tuberculosis: 25mg/kg body weight/day for the first 60 days, then drink 15mg/kg body weight/day, maximum 1g/day.

Preventive:

15mg/kg body weight/day, a single dose, combined drugs should be maintained at the recommended dose.

Patients with renal failure:

Dosage reduction and change the dose range depending on the degree of renal failure. Need to adjust the dose according to the concentration of ethambutol in the blood.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Signs and symptoms:

There is no sign of acute poisoning with normal dose. Acute poisoning usually occurs at a dose higher than 10 g with common symptoms such as nausea, abdominal pain, fever, confusion, hallucinations and other diseases of optic nerves.

Management:

When ethambutol poisoning must quickly wash the stomach and conduct artificial kidney fertilizer or peritoneal fertilizer to quickly reduce blood levels.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using ethambutol 400mg, you may experience unwanted effects (ADR).

Common

Hypertension of blood uric acid, especially in the first 2 weeks, fever, joint pain.

Gasmearing neuritis, vision loss, irrespective of red with green.

Rare

headache, fever, joint pain, skin reactions. Nausea, vomiting, anorexia, abdominal pain. Peripheral neuritis.

Instructions on how to handle ADR

Notify the doctor the unwanted side effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

ETHAMBUTOL 400mg contraindications in the following cases:

People with a history of hypersensitivity to ethambutol.

Patients with optic neuritis.

Be cautious when using

with patients with impaired renal function, the dose must be reduced based on the concentration of ethambutol in serum.

Be cautious with eye -catching people, the elderly and children, especially children who are 6 years old because it is difficult to detect and evaluate changes in visual function.

The ability to drive and operate machinery

There is no research data but should be careful when used because the drug also causes side effects on optic nerves, headache.

Pregnancy

Ethambutol passed the placenta but there was no risk of notification because of the drug during pregnancy.

The period of breastfeeding

Ethambutol through milk should not be used for children because it is impossible to indicate visual disorders.

Medicinal interaction

Simultaneous use of ethambutol with isoniazid and other neurotoxic pills (disulfiram, chloroquine, hydralazine, etc.) can increase the risk of neurotoxicity, such as visual and peripheral neuritis.

With aluminum aluminum -containing aluminum hydroxide reduces the absorption of ethambutol in some patients.

Storage

under 30 ° C, avoid light.

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