Etodagim Agimexpharm treatments for osteoarthritis, acute gout or fake gout (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Etodolac

Ingredient

Composition information	Content
Etodolac	200mg

Uses

Indications

Etodagim drugs are indicated in the following cases:

Treatment of osteoarthritis, acute gout or gout.

Pain after tooth extraction.

Surgical pain, postpartum pain.

Sutta and acute muscle pain due to many reasons.

Pharmacy

Etodolac, derivative of Pyrano-Indol-ACetic acid, is a nonsteroidal anti-inflammatory drug (NSAIDs) with anti-inflammatory, analgesic, fever. Like other non -steroid anti -inflammatory drugs, Etodolac's action mechanism is to inhibit cyclooxygenase enzyme related to prostaglandin synthesis.

pharmacokinetics

Etodolac is quickly absorbed through the gastrointestinal tract. After taking 200mg of Etodolac, the peak concentration in plasma is 10 - 18mcg/ml achieved within 1-2 hours. After many medications within the limits of treatment, plasma concentrations are only slightly higher than after drinking only once. Etodolac can be used at meals or at the same time as antacids because the level of Etodolac absorption is not affected when the drug is used after meals or with antacids. More than 99% Etodolac binds to plasma proteins. Etodolac's semi -cancellation time in plasma is 6 - 7.4 hours.

Etodolac is metabolized most in the liver.

Etodolac excreted mainly in urine (about 72% of oral dose) in the form of hydroxylation metabolites and the form associated with glucuronide, a little (about 16% of oral dose) can be discharged through feces.

Before taking Etodagim Agimexpharm treatments for osteoarthritis, acute gout or fake gout (10 blisters x 10 tablets)

How to use

Oral drugs.

Dosage

Common dose

400 mg/day, drink in the middle of the meal.

Adults

osteoarthritis/gout, a maximum dose of 1200mg/day. If the patient is

Dental pain

1 tablet/time x 3-4 times/day.

Stretching tendonitis, epidemic inflammation, elbow inflammation, tendonitis, postpartum cutting pain

2 tablets/time x 2-3 times/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

There has been no report on the overdose of Etodolac. Symptoms of acute overdose may occur as an overdose of nonsteroidal anti -inflammatory drugs with manifestations: sleep, drowsiness, nausea, vomiting, and epigastric pain. Stomach bleeding can occur. High blood pressure, acute renal failure, respiratory failure and coma may occur, but rare.

Handling

usually treat symptoms and support. If you have overdose, it is necessary to apply the following measures to increase elimination and inactivity: gastric lavage, vomiting and diuretic, drinking activated carbon or salt bleach. It is difficult to eliminate by separation because 99% of plasma protein.

What to do when forgetting 1 dose?

No report.

Side Effects

When using Etodagim, you may experience unwanted effects (ADR).

Digestive system: Nausea, vomiting, indigestion, gastritis, abdominal pain, constipation, flatulence, vomiting blood, gastrointestinal ulcers and black stools. Gastrointestinal bleeding, sometimes stomach bleeding and gastrointestinal tract without abnormal pain symptoms. Very rare (very rare). Reduce blood flow to the kidneys and impaired renal function. Damage is especially likely to occur in patients with kidney function or congestive heart failure.

Stop using medication if the patient appears serious side effects: black stool, abnormal stomach pain, persistent, arm pain, jaw, chest, vomiting blood, breathing, abnormal sweat, weak, abnormal vision changes.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Etodagim drugs contraindicated in the following cases:

Patients sensitive to Etodolac, aspirin or other nonsteroidal anti -inflammatory drugs.

Patients are suffering from acute asthma, rhinitis, urticaria or other allergic reactions.

Patients with progressive stomach - duodenal ulcer or have a history of gastrointestinal bleeding.

before and after heart surgery.

Precautions when using

Heart thrombotes

Non -steroid anti -inflammatory drugs (NSAIDs), non -aspirin, using systemic sugar can increase the risk of cardiovascular thrombosis, including myocardial infarction and stroke, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time. The risk of cardiovascular thrombosis is recorded mainly at high doses.

Doctors need to periodically evaluate the appearance of cardiovascular events, even if the patient has no previous cardiovascular symptoms. Patients should be warned of symptoms of serious cardiovascular events and need to visit the doctor as soon as they appear.

As well as nonsteroidal anti -inflammatory drugs (NSAIDs), Etodolac has the ability to increase the risk of myocardial infarction or stroke. Larger risk factors for patients with cardiovascular disease or increased risk of cardiovascular disease in subjects with other risk factors such as smoking, family history with cardiovascular disease or additional hypertension or diabetes, long -term use. Do not use the drug immediately after the sphere of the heart.

To minimize the risk of adverse events, Etodagim is needed at the lowest daily doses in the shortest possible time as possible.

Elderly patients: The risk of stomach bleeding is higher.

Precautions for patients with impaired liver or kidney function, patients with water retention, high blood pressure, heart failure, the elderly, nursing women.

Not researched using Etodolac for children.

The ability to drive and operate machinery

Although there is no study proves the impact of Etodolac on the ability to drive or operate machinery, but should be cautious because the drug can cause headaches, mild dizziness and fatigue.

Pregnancy

Avoid for pregnant women because of the safety of drugs for pregnant women who have not been verified, should only be used in actually necessary cases.

Breastfeeding period

Avoid for women to breastfeed because of the safety of the drug for breastfeeding women who have not been verified, should be used only in case of really necessary.

Drug interaction

Used in combination with warfarin increases the risk of bleeding.

Used with diuretics can reduce the effect of sodium -out of furosemid and diuretics in some patients.

Do not be used with other nonsteroidal anti -inflammatory drugs because of the increase in side effects (especially on the digestive tract).

Similar to other nonsteroidal anti -inflammatory drugs, Etodolac with the effect on the kidney prostaglandin can change the excretion that leads to increased serum concentration of cyclosporine, digoxin, methotrexate and increases the toxicity of these drugs.

Etodolac can increase the level of lithium in the blood due to reducing lithium elimination from the body by the kidneys. Increased lithium concentration can cause lithium poisoning.

Storage

temperature below 30⁰C, avoid moisture and light.

Other drugs

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