EU Vaginal PV PV Treatment of Vaginitis (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Metronidazol, neomycin, nystatin

Ingredient

Composition information	Content
Metronidazol	500mg
Neomycin	65000iu
Nystatin	100000iu

Uses

Indications

EU TKKynan vaginal tablets are used to treat vaginitis caused by sensitive pathogens and nausical vaginitis.

Pharmacology

Pharmacological group: anti -infection combination drugs

EU TKynan has a combination of Metronidazol, Neomycin Sulfate and Nystatin. Therefore, the drug has the effect of treating local vaginal infections due to various causes such as bacterial infections, fungal infections, parasites or many pathogens at the same time.

Metronidazol: Metronidazol is a derivative 5 - nitro - imidazole, has a broad activity on the protozoa such as Entamoeba Histolytica, Giardia Lamblia and Trichomonas Vaginalis and in anaerobic bacteria. When bacterial vaginal cervicitis, Metronidazole will cause the vaginal bacteria to return to normal in the majority of patients who use drugs: Metronidazole does not affect the normal bacteria in the vagina. The mechanism of action of Metronidazol is not very clear, may be removed into toxic intermediate substances with cells, these substances bind to the twisted structure of the DNA molecule that breaks these fibers and eventually causes dead cells.

Neomycin Sulfate: Neomycin is an aminoglycoside antibiotic with similar mechanisms and spectrums. Neomycin's antibacterial spectroscopy includes bacteria such as Staphylococcus aureus, Escherichia Coli, Heamophilus Influenzae, Klebsiella, Entobacter of all kinds, Neisseria of all kinds. Neomycin does not work with Pseudomonas Aeruginosa, Serratia Marcescens, Streptococci including Streptococcus Pneumoniae or Streptococcus hemolysis. Neomycin is quite commonly used, so it has a relatively wide anti -drug notice, typically Staphylococcus staph, some Salmonella, Shigella and Escherichia Coli series.

Nystatin: Nystatin is an anti -fungal antibiotic extracted from streptomyces noursei mushrooms, very little soluble in water. Nystatin has the effect of restraining or eliminating fungi depending on the concentration and sensitivity of the fungus, not affecting the normal bacteria on the body. The most sensitive is the yeast and has a very good effect on Candida Albicans.

Nystatin effect mechanism: Due to the link with the sterol of the cell membrane sensitive fungi, nystatin changes the permeability of the mushroom membrane. Nystatin tolerates well even when long -term treatment and does not cause drug resistance.

Dynamic pharmacokinetics

Metronidazol: less than the body diffraction when used by vaginal lines. Selling time in plasma from 8 to 10 hours. Under 20% of the drug associated with plasma proteins. Quickly diffuse into the lungs, kidneys, liver, bile, cerebrospinal fluid, skin, saliva and vaginal discharge. Metronidazol passes the placenta and into breast milk.

Maximum metabolism mainly in the liver into 2 non -combined oxidant metabolites (5 - 30% active). Excretion mainly in the urine. About 35% - 65% of the absorbed dose is excreted in the urine in the form of metronidazol or in the form of oxidation.

neomycin sulfate: When using vaginal lines, drugs absorbed in blood circulation in very low amounts. Neomycin is distributed into breast milk. Half lifetime elimination in plasma is 2-3 hours. Neomycin is not metabolized and eliminated in the form of unchanged urine ...

Nystatin: The drug is almost absorbed in the whole body when used in the form of vaginal placement.

Before taking EU Vaginal PV PV Treatment of Vaginitis (1 blister x 10 tablets)

How to use

EU Tikynan tablets for gynecological order.

Moisturize the pill by dipping in water for 20 to 30 seconds before placing it into the vagina. Patients should keep the position within 15 minutes after placing.

Dosage

recommended dose: 1 vaginal tablet 1 or 2 times/day for 10 consecutive days, combined with oral treatment if necessary.

Specific dose depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms of overdose:

There has been no report on overdose symptoms when using the right way to use vaginal drugs.

In case of accidentally taking the medicine, but it must be with the dose of Metronidazol> 12 g (over 24 EU TKynan tablets; the active ingredients of Neomycin and Nystatin are very rarely absorbed), the overdose symptoms may occur related to Metronidazol such as nausea, vomiting, loss of air conditioning, convulsions.

In addition, other symptoms have been recorded in high doses and/or prolonged use such as neutropenia, peripheral neural inflammation, however, symptoms will end up when stopping treatment.

Management:

In case of taking an overdose, the EU TKKynan is discontinued immediately after detecting and treating symptoms because Metronidazol has no specific antidote.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using the drug, there are common unwanted effects (ADR) such as:

Rare:

Gastroentrial disorders - benign intestines: Nausea, mouth with unpleasant metal taste, anorexia, epigastric shrinkage, vomiting, diarrhea.

Exception:

allergies (urticaria, itching), hot overflow, tongue inflammation with dry mouth.

headache, dizziness.

Neutral leukemia can recover when the drug is stopped.

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

EU TKKynan gynecological tablets are contraindicated in the following cases:

Hypersensitivity to imidazol or other ingredients in the formula.

Be cautious when using

Do not intercourse during EU TKKynan treatment.

Should treat both people at the same time, regardless of whether or not there is no clinical signs.

Personal hygiene (underwear) is required to avoid infection.

Do not stop treating during menstruation.

Related to Metronidazol:

Check the number of white blood cells in patients with a history of blood disorders or patients treated at high doses and/or for a long time.

No treatment with Metronidazol for more than 10 days and should not be repeated more than 2-3 times/year. Stop treatment if occurs in place or allergic reactions or symptoms such as mental confusion, dizziness, loss of movement air conditioning.

Neurological condition may be worse in patients with central neurological disorders or peripheral, chronic or severe progression. Alcoholic drinks should be reduced during treatment.

Related to neomycin and nystatin:

Should limit the treatment time to reduce the risk of selecting bacteria/fungi resistance or superinfection by these bacteria/fungi.

sensitive to local antibiotics Neomycin on the spot can adversely affect the use of that antibiotic or the same group antibiotics in the future.

The effect of the drug on the ability to drive and operate machinery

The drug can cause dizziness, when using the drug should not drive or operate machinery.

Use drugs for women during pregnancy and lactation

Pregnant women:

Because the drug contains neomycin that can be toxic to hearing or entering the blood, should not be used during pregnancy.

breastfeeding women:

There is no enough data on the use of EU TKynan whether it is excreted in breast milk. Should avoid using this drug during breastfeeding.

Drug interaction

is not coordinated with:

Sperm killers: Any on -site vaginal treatment can be inactivated in place contraception with spermicide.

Alcohol: Due to the effect of alcoholic syndrome (hot, blushing, vomiting, fast heartbeat). Do not use at the same time with alcoholic drinks or pharmaceuticals.

disulfiram: can cause delusion or confusion.

Precautions when combined with:

Oral anti -dynamic drugs (especially Warfarin): Increases the effects of anticoagulant oral medications and the risk of bleeding due to the loss of catabolism of these drugs in the liver. Should regularly test prothrombin time and monitor Inr. It is necessary to adjust the anticoagulant dose during treatment with Metronidazol and 8 days after treatment.

It should be noted when combined with:

5-fluorouracil; Increase the toxicity of 5-fu due to reducing the clearance of this drug.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

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